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- Fundamental aspects
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1. Inflammation and tissue homeostasis
- Prof. Herman Waldmann
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2. Introduction to the immune system
- Prof. Herman Waldmann
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3. Hematopoiesis: the making of an immune system
- Prof. Paul J. Fairchild
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4. Inflammation: purposes, mechanisms and development
- Prof. Pietro Ghezzi
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5. Phagocytosis
- Dr. Eileen Uribe-Querol
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6. Regulated cell death mechanisms and their crosstalk with the immune system 1
- Dr. Luis Alberto Baena-Lopez
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7. Regulated cell death mechanisms and their crosstalk with the immune system 2
- Dr. Luis Alberto Baena-Lopez
- Innate immunity
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11. Cells of the innate immune system
- Prof. Kevin Maloy
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12. Microbial recognition and the immune response
- Dr. Dana Philpott
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13. Toll-like receptor signalling during infection and inflammation
- Prof. Luke O'Neill
- Intercellular mediators
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14. Chemokines
- Dr. James E. Pease
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15. Cytokines
- Prof. Iain McInnes
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16. IL-1 family cytokines as the canonical DAMPs of the immune system
- Prof. Seamus Martin
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17. Glycoimmunology
- Prof. Paula Videira
- Adaptive immunity B cells
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20. Antigen recognition in the immune system
- Prof. Herman Waldmann
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21. B cell biology
- Prof. Richard Cornall
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22. Antibody structure and function: antibody structure
- Dr. Mike Clark
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23. Antibody structure and function: antibody function
- Dr. Mike Clark
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24. Antibody genes and diversity
- Dr. Mike Clark
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25. In vivo antibody discovery and hybridoma technology
- Prof. Dr. Katja Hanack
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26. Antibody engineering: beginnings to bispecifics and beyond
- Dr. Ian Wilkinson
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28. The immunobiology of Fc receptors
- Prof. Mark Cragg
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29. Immunoreceptors
- Prof. Anton van der Merwe
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30. Affinity, avidity and kinetics in immune recognition
- Prof. Anton van der Merwe
- Adaptive immunity T cells
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31. The thymus and T cell development: a primer
- Prof. Georg Holländer
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32. Lineage decisions in the thymus: T cell lineage commitment
- Prof. Bruno Silva-Santos
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33. Lineage decisions in the thymus: αβ and γδ T cell lineages
- Prof. Bruno Silva-Santos
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34. CD4 T cell subsets
- Dr. Brigitta Stockinger
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35. Cytotoxic T lymphocytes
- Prof. Gillian Griffiths
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36. Gamma delta T-cells
- Prof. Bruno Silva-Santos
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37. Tfh and Tfr cells
- Prof. Luis Graca
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38. Tissue resident memory T cells (TRM)
- Dr. Marc Veldhoen
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39. Mathematical modeling in immunology
- Prof. Ruy M. Ribeiro
- The importance of the MHC in immunity
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40. The MHC and MHC molecules 1
- Prof. Jim Kaufman
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41. The MHC and MHC molecules 2
- Prof. Jim Kaufman
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42. Natural killer cells
- Dr. Philippa Kennedy
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44. NK cells in viral immunity
- Prof. Lewis Lanier
- Lymphocyte activation
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45. Signal transduction by leukocyte receptors
- Dr. Omer Dushek
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46. Immunological memory 1
- Prof. David Gray
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47. Immunological memory 2
- Prof. David Gray
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48. Studying immune responses “one cell at a time”
- Dr. Mir-Farzin Mashreghi
- Major cellular partners in immunity
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49. The mononuclear phagocyte system - tissue resident macrophages: distribution and functions
- Prof. Emeritus Siamon Gordon
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50. The mononuclear phagocyte system: tissue resident macrophages - activation and regulation
- Prof. Emeritus Siamon Gordon
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51. Dendritic cells: professional antigen presenting cells
- Prof. Paul J. Fairchild
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52. Mucosal immunology
- Prof. Daniel Mucida
- Immunological tolerance and regulation
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53. Self-tolerance
- Prof. Herman Waldmann
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54. Tolerance and autoimmunity
- Prof. Emerita Anne Cooke
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55. The balance between intestinal immune homeostasis and inflammation
- Prof. Dr. Janneke Samsom
- Translational immunology - immune deficiency
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56. Primary immunodeficiency disorders
- Dr. Smita Y. Patel
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57. Changes in innate and adaptive immunity during human ageing 1
- Dr. Roel De Maeyer
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58. Changes in innate and adaptive immunity during human ageing 2
- Dr. Roel De Maeyer
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59. The aging immune system
- Prof. Ana Caetano
- Translational immunology - protection against pathogenic microbes
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60. Immune responses to viruses
- Prof. Paul Klenerman
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61. HIV and the immune system
- Prof. Quentin Sattentau
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62. COVID-19: the anti-viral immune response
- Prof. Danny Altmann
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63. Bacterial immune evasion
- Prof. Christoph Tang
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64. The immunology underlying tuberculosis
- Prof. Thomas R. Hawn
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65. Innate immunity to fungi
- Prof. Gordon D. Brown
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66. Parasite immunity: introduction and Plasmodium
- Dr. Catarina Gadelha
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67. Parasite immunity: Leishmania and Schistosoma
- Dr. Catarina Gadelha
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68. Vaccination
- Dr. Anita Milicic
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69. The history of vaccines 1
- Prof. Emeritus Anthony R. Rees
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70. The history of vaccines 2
- Prof. Emeritus Anthony R. Rees
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71. The history of vaccines 3
- Prof. Emeritus Anthony R. Rees
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72. The science of vaccine adjuvants
- Dr. Derek O'Hagan
- Translational immunology - hypersensitivity, autoimmune disease and their management
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73. Hypersensitivity diseases: type 1 hypersensitivity
- Prof. Herman Waldmann
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74. Innate lymphoid cells in allergy
- Prof. Emeritus Shigeo Koyasu
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75. Hypersensitivity diseases: type II-IV hypersensitivity
- Prof. Sara Marshall
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76. B cells at the crossroads of autoimmune diseases
- Dr. Xiang Lin
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77. Interleukin-17: from clone to clinic
- Prof. Leonie Taams
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78. Autoimmunity and type 1 diabetes
- Prof. Emerita Anne Cooke
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79. What is new in type 1 diabetes?
- Prof. Åke Lernmark
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80. Antibodies to control or prevent type 1 diabetes
- Dr. Robert Hilbrands
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81. Monoclonal antibodies in haemato-oncology
- Prof. Mark Cragg
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82. Therapeutic antibodies
- Dr. Geoffrey Hale
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83. Neuroimmunometabolism
- Prof. Ana Domingos
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84. The immunology of multiple sclerosis
- Dr. Joanne Jones
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85. Understanding myasthenia gravis and advances in its management
- Prof. Henry J. Kaminski
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86. The immunology underlying rheumatic diseases
- Dr. Hussein Al-Mossawi
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88. Complement and lupus
- Prof. Marina Botto
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89. Immune mechanisms in liver diseases
- Prof. Paul Klenerman
- Translational immunology - transplantation immunology
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90. Principles of transplantation: overview of the immune response
- Prof. Emerita Kathryn Wood
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91. Factors influencing outcomes in clinical transplantation 1
- Prof. Emerita Kathryn Wood
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92. Factors influencing outcomes in clinical transplantation 2
- Prof. Emerita Kathryn Wood
- Translational immunology - cancer immunology
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93. Cancer immunology
- Prof. Tim Elliott
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94. Cancer immunotherapy
- Prof. Tim Elliott
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95. Myeloid-derived suppressor cells in cancer
- Prof. Dmitry Gabrilovich
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96. IL-2 in the immunotherapy of autoimmunity and cancer
- Prof. Thomas Malek
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97. Latest advances in the development of CAR & TCR T-cell treatments for solid tumours
- Dr. Else Marit Inderberg
Printable Handouts
Navigable Slide Index
- Introduction
- The thymus: primary T lymphoid organ
- An education
- The capacity for self-non-self discrimination (1)
- The capacity for self-non-self discrimination (2
- T cell development (1)
- T cell development: thymus morphology
- T cell development (2)
- The thymic stromal microenvironment
- TECs: function and structure
- TEC development
- FOXN1: master regulator
- TEC development: FOXN1 disruption
- Thymus development
- TCR and selection
- TCR rearrangement
- Positive and negative thymocyte selection
- The rules of engagement'
- Outcome of selection
- CD4/CD8 decision (1)
- CD4/CD8 decision (2)
- Thymic NKT cell development
- Expression of tissue-restricted antigens (TRAs) (1)
- Expression of tissue-restricted antigens (TRAs) (2)
- Single cell expression of TRAs
- Central T cell tolerance and loss
- AIRE-deficiency
- Summary
- Thank you
Topics Covered
- The thymus
- The thymus microenvironment
- T cell development
- Cortical thymic epithelial cell function
- Medullary thymic epithelial cell function
- T cell self-non-self-discrimination
- Expression of tissue-restricted antigens
- AIRE-deficiency
Links
Series:
- The Immune System - Key Concepts and Questions
- Periodic Reports: Advances in Clinical Interventions and Research Platforms
Categories:
Therapeutic Areas:
Talk Citation
Holländer, G. (2022, April 3). The thymus and T cell development: a primer [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 27, 2024, from https://hstalks.com/bs/4554/.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Georg Holländer has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
A selection of talks on Physiology & Anatomy
Transcript
Please wait while the transcript is being prepared...
0:00
Hello and welcome to
this presentation.
My name is George Holländer.
I am a professor at the University
of Oxford in the United Kingdom,
with affiliations to the ETH Zürich and the
University of Basel, both in Switzerland.
We are talking today about
the thymus and T
cell development,
and the presentation is a
primer into this topic.
0:25
The thymus is the
primary T lymphoid organ
and sits in the chest cavity
in front of the heart.
It's anatomical location is
between the two pulmonary lobes.
If analysed by histology,
it will reveal a
lobulated structure
where each of the lobules has
a cell dense outer cortex and
a central medulla
that appears to
be less packed with
lymphoid cells.
0:59
What is the overall
function of the thymus?
The thymus is similar to an
Institute of Higher Education.
Where precursor cells -
shown as the students -
enter the institute
or the university.
After a while, they will successfully
exit as fully trained individuals.
During their time
at the university,
they are being taught to achieve
certain functional capacities.
The teachers - shown as the
individuals with the yellow coats -
have a particular task for
the students to achieve.
Namely the creation of a
graduation cap that fulfils
certain criteria.
In biological terms,
the students are the
developing T cells,
and the graduation cap is
a T-cell antigen receptor
that conforms to certain
qualitative criteria.
Now, as you can see some of the
students are well on their way
and have chosen mortars that don't conform
to the overall expectation of the square.
Now, in particular,
there is a student
in the middle that is being told
off by the teacher and
sent away in shame.
What happens to this example,
but obviously not in real life,
is this student will await
a very drastic outcome
and will eventually be
deleted from the classroom.
This is really the fate of most of the T
cells that are being educated in the thymus.
The overall goal of
the immune system is