Pigmentation of skin

Published on May 4, 2014   33 min
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Hello, my name is Glynis Scott. I'm a professor of dermatology and pathology at the University of Rochester. This talk will be on pigmentation of skin and will focus primarily on pigmentation of human skin.
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In this talk I'm going to cover five main areas. I'm first going to discuss melanin, its basic molecular nature and its secondary structure. I'm then going to discuss tyrosinase, which is the enzyme that catalyzes the rate-limiting step in melanin synthesis and discuss, in some detail, how tyrosinase is regulated. In the third part of the talk, I'm going to discuss melanocytes, which are the cells that produce melanin. And I'm going to go over melanosomes, which are subcellular organelles within melanocytes in which melanin is synthesized. In the fourth part of the talk, I'm going to discuss the process of tanning, which is the response of the skin to ultraviolet irradiation. And finally, in the last part of the talk, I'm going to discuss the evolutionary pressures that have led to the distinctive patterns of skin pigmentation across the globe.