Assessment of renal function

Published on August 31, 2016   36 min

Other Talks in the Series: The Kidney in Health and Disease

Well, hello. My name is Jochen Raimann, and I am a senior scientist and manager of data analytics at the Renal Research Institute in New York City, in the United States. And, I do have the pleasure to present the assessment of renal function, a topic of great importance in clinical nephrology.
So, we'll basically present the topic stretched into two different bullet points. So, we'll first talked about glomerular filtration rate in general. Then secondly, about markers of glomerular filtration rates, and specifically about the assessment of renal clearance and the simplified approaches for estimating the glomerular filtration rate which are currently in use in clinical nephrology. So, let's start now with the glomerular filtration rate.
So in general, the kidneys are, implicated into several and different physiological processes in the body. They are central to the excretion of metabolic waste products and foreign chemicals. They are central to the regulation of water and electrolyte balances and also for the regulation of body fluid osmolality and electrolyte concentrations. They are of great importance for the regulation of the acid-base balance, to regulate the arterial pressure by various hormonal mechanisms. They're also central to secretion, metabolism, and excretion of hormones and also serve for gluconeogenesis.
The glomerular filtration rate is one of the main tasks of the kidneys. It's essentially regulated by the blood flow through the kidney. Essentially, this is determined by the flow from the afferent arteriole into the glomerulars. And after the blood has passed through the glomerulars, it will leave through the efferent arteriole. Essentially, solids that pass through the glomerulars can be filtrated in the glomerulars. And will, in addition, be secreted from the peritubular capillaries. This being said, so the solid is passing through their front arteriole into the glomerulars and is being filtered into the Bowman's capsule and will then reach the tubulars. This being said, essentially arithmatically, this research in the urinary excretion rate of a solid is being determined by the filtration rate minus the reabsorption rate because solids passing through the tubulars are subject to reabsorption along its way into the bladder. And in addition, this also will be added back to the secretion rate by solids that are secreted from the peritubular capillaries.