0:00
Well, hello.
My name is Jochen Raimann,
and I am a senior scientist
and manager of data analytics
at the Renal Research Institute
in New York City,
in the United States.
And, I do have
the pleasure to present
the assessment of renal function,
a topic of great importance
in clinical nephrology.
0:17
So, we'll basically present the topic
stretched into two
different bullet points.
So, we'll first talked about
glomerular filtration rate
in general.
Then secondly, about markers of
glomerular filtration rates,
and specifically about
the assessment of renal clearance
and the simplified approaches
for estimating
the glomerular filtration rate
which are currently in use
in clinical nephrology.
So, let's start now with the
glomerular filtration rate.
0:45
So in general, the kidneys are,
implicated into several
and different physiological
processes in the body.
They are central to the excretion
of metabolic waste products
and foreign chemicals.
They are central
to the regulation of water
and electrolyte balances
and also for the regulation
of body fluid osmolality
and electrolyte concentrations.
They are of great importance
for the regulation of the
acid-base balance,
to regulate the arterial pressure
by various hormonal mechanisms.
They're also central to secretion,
metabolism,
and excretion of hormones
and also serve for gluconeogenesis.
1:25
The glomerular filtration rate
is one of the main tasks
of the kidneys.
It's essentially regulated
by the blood flow
through the kidney.
Essentially, this is determined
by the flow from the afferent arteriole
into the glomerulars.
And after the blood has passed
through the glomerulars,
it will leave
through the efferent arteriole.
Essentially, solids that pass
through the glomerulars
can be filtrated in the glomerulars.
And will, in addition,
be secreted
from the peritubular capillaries.
This being said,
so the solid is passing
through their front arteriole
into the glomerulars and is being
filtered into the Bowman's capsule
and will then reach the tubulars.
This being said,
essentially arithmatically,
this research in the urinary
excretion rate of a solid
is being determined
by the filtration rate
minus the reabsorption rate
because solids passing
through the tubulars
are subject to reabsorption
along its way into the bladder.
And in addition,
this also will be added
back to the secretion rate
by solids
that are secreted
from the peritubular capillaries.
