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- Advances in the Understanding of Etiology (I)
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1. Infection and autoimmunity: a two-way relationship
- Dr. Ricard Cervera
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2. Autoimmunity and atherosclerosis
- Prof. Johan Frostegard
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3. Endothelium and autoimmunity
- Prof. Pier Luigi Meroni
- Advances in the Understanding of Etiology (II)
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4. Prolactin has a pathogenic role in systemic lupus erythematosus
- Prof. Luis Jara-Quezada
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5. Sjögren's syndrome: current knowledge and future prospects
- Prof. Athanasios G. Tzioufas
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6. Genetic and environmental triggers of autoimmune thyroid diseases
- Prof. Yaron Tomer
- Advances in Pathogenesis and Clinical Manifestation
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8. Pathogenic mechanisms of autoantibodies: circulating and local antibodies that form immune complexes
- Dr. Luís Eduardo Coelho Andrade
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9. Pathogenic mechanisms of autoantibodies: antibodies to intracellular and membrane-bound antigens
- Dr. Luís Eduardo Coelho Andrade
-
10. What causes primary biliary cholangitis?
- Dr. M. Eric Gershwin
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11. Capillaroscopy in autoimmune rheumatic diseases
- Prof. Maurizio Cutolo
- Advances in Diagnostic Methodologies (I)
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12. The past, present & future of ANA testing: history and challenges of ANA
- Prof. Marvin J. Fritzler
-
13. The past, present & future of ANA testing: changing bandwidth and future of ANA
- Prof. Marvin J. Fritzler
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14. Diagnostic methods in autoimmunity
- Mr. Steven Binder
-
15. Systemic lupus erythematosus: novel aspects of pathogenesis and treatment 1
- Prof. Chaim Putterman
- Dr. Noa Schwartz
-
16. Systemic lupus erythematosus: novel aspects of pathogenesis and treatment 2
- Prof. Chaim Putterman
- Dr. Noa Schwartz
-
17. Novel aspects of systemic sclerosis
- Prof. Gabriele Valentini
- Advances in Diagnostic Methodologies (II)
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18. An update on the multiple faces of celiac disease
- Prof. Aaron Lerner
-
19. Protective autoantibodies
- Prof. Elias Toubi
-
21. Rheumatic fever: a model of a post-infectious autoimmune disease
- Prof. Jorge Kalil
- Treatments of autoimmune diseases
-
22. Intravenous immunoglobulins: clinical evidence
- Prof. Shaye Kivity
- Latest Developments in the Field
-
23. Adjuvants and autoimmunity
- Dr. Eitan Israeli
-
24. Antiphospholipid syndrome (APS): from pathogenesis to treatment
- Prof. Roger Levy
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25. Vitamin D and autoimmunity
- Dr. Shir Azrielant
-
26. Pregnancy in rheumatic diseases
- Prof. Pier Luigi Meroni
- Archived Lectures *These may not cover the latest advances in the field
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27. Pathogenic mechanisms of autoantibodies
- Prof. Cees Kallenberg
-
28. B lymphocytes on the frontline of autoimmunity
- Prof. Pierre Youinou
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29. Apoptotic cell clearance deficiency
- Prof. Martin Herrmann
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30. Auto-antibodies as predictors of autoimmune disease
- Dr. Nicola Bizzaro
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31. Innate immunity and natural autoantibodies
- Prof. Luc Mouthon
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32. Accelerated atherosclerosis in autoimmune rheumatic disease
- Dr. Andrea Doria
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33. Pregnancy in autoimmune rheumatic diseases
- Prof. Angela Tincani
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36. Immunologic mechanisms in systemic lupus erythematosus
- Prof. Kok-Yong Fong
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37. Osteoimmunology
- Prof. João Eurico Fonseca
- Ms. Joana Caetano-Lopes
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38. ANCA-associated systemic vasculitides
- Prof. Loic Guillevin
-
39. The common origin for diverse autoimmune diseases
- Prof. Juan-Manuel Anaya
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40. Anti-cytokine therapy in rheumatoid arthritis
- Prof. Piercarlo Sarzi-Puttini
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41. Sjogren's syndrome: autoimmune epithelitis
- Prof. Haralampos Moutsopoulos
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42. Vitamin D and autoimmunity
- Dr. Howard Amital
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43. Intravenous immunoglobulins: myth and reality
- Prof. Zera Tellier
Printable Handouts
Navigable Slide Index
- Introduction
- Antibodies to intracellular antigens
- Antibodies to membrane-bound antigens
- High sensitivity of autoantibodies to membrane-bound antigens
- Low sensitivity of autoantibodies to intracellular antigens
- Targets of autoantibodies
- SS-A/Ro-like fine speckled nuclear ANA pattern
- The case for anti-SS-A/Ro 60kDa antibodies
- In vivo antinuclear antibody phenomenon in mice
- In vivo antinuclear antibody phenomenon in humans
- Antibody-dependent cell cytotoxicity in cultures keratinocytes
- ANCA (anti-neutrophil cytoplasm antibodies)
- Clinical evidence for pathogenic role of ANCA
- Experimental evidence for pathogenic role of ANCA
- The case of antibodies to chromatin
- Plasmacytoid dendritic cells internalize immune complexes
- Immune-mediated necrotizing myopathies (IMNM)
- Clinical characteristics of IMNM
- 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase
- Signal Recognition Particle (SRP)
- Pathogenicity of anti-SRP and anti-HMGCR antibodies
- In vivo pathogenicity of anti-SRP or anti-HMGCR autoantibodies
- Anti-SRP antibodies decrease grip and muscle strength
- Anti-HMGCR antibodies decrease grip and muscle strength
- Anti-SRP or anti-HMGCR antibodies induce necrosis of myofibers
- Immunization with recombinant SRP or HMGCR
- C3 KO abrogates anti-SRP or anti-HMGCR mediated disease
- Pathogenicity of autoantibodies
- Autoantibodies to antigens at the outer cell surface
- Transient disease after placental transfer of autoantibodies
- Autoantibodies against antigens of the epithelial intercellular cement
- Anti-desmoglein 3 antibodies & Pemphigus vulgaris
- Molecular mechanisms of anti-desmoglein 3 antibodies pathogenicity
- Immune-mediated membranous nephropathy (1)
- Immune-mediated membranous nephropathy (2)
- Pathogenicity of antibodies to NEP
- Neonatal membranous GN
- Autoantibodies to PLA2R
- Serum anti-PLA2R and proteinuria under treatment
- Anti-PLA2R serum levels & disease activity & prognosis
- Chronic idiopathic urticaria
- Autoantibodies in chronic idiopathic urticaria
- Evidence for pathogenicity of anti-FcεRIα antibodies
- In vivo autologous serum skin test
- In vitro activation of basophils from autologous serum
- Autoimmune encephalopathies (1)
- Autoimmune encephalopathies (2)
- Characteristic topographic distribution for each targeted autoantigen
- Neurologic diseases & autoantibodies to surface antigens
- NMDA receptor
- NMDA receptor encephalopathy
- Pathogenic autoantibodies targeting NMDA receptors
- Transient anti-NMDAR encephalitis due to transplacental transmission
- Eugène Devic’s (1894)
- Devic’s neuromyelitis optica
- Anti-aquaporin 4 antibodies
- Pathogenic role of anti-aquaporin 4 antibodies: pros & cons
- Pathogenicity of anti-aquaporin 4 depends on complement
- Concluding remarks
Topics Covered
- Autoantibodies targeting cell membrane-bound antigens
- Autoantibodies targeting intracellular antigens
- Autoantibodies as a result of damage to target tissues
- Autoantibodies preceding the clinical onset of diseases
- Pathogenic autoantibodies in rheumatology, neurology, dermatology and nephrology
Links
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Talk Citation
Andrade, L.E.C. (2020, June 30). Pathogenic mechanisms of autoantibodies: antibodies to intracellular and membrane-bound antigens [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 3, 2024, from https://doi.org/10.69645/JQHI9795.Export Citation (RIS)
Publication History
Financial Disclosures
- There are no commercial/financial matters to disclose.
Pathogenic mechanisms of autoantibodies: antibodies to intracellular and membrane-bound antigens
Published on June 30, 2020
34 min
A selection of talks on Immunology
Transcript
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0:00
My name is Luis Andrade.
I am an Associate Professor of Medicine at Universidade Federal De São Paulo, Brazil,
Medical Consultant for Immunology at the Fleury Laboratory and
Chair of the Quality Standardization and Assessment Committee of the IUIS.
In the second part of the talk on pathogenic mechanisms of autoantibodies,
I will focus on antibodies to intracellular antigens and to
membrane-bound antigens and discuss
possible pathogenic mechanisms for these two classes of autoantibodies.
0:43
At this point, it is important to consider that we have two classes of autoantigens;
intracellular and extracellular antigens.
Antibodies to intracellular antigens include chromatin antigen, spliceosome antigens,
DNA topoisomerase 1, tRNA synthetases,
liver kidney microsome, mitochondria pyruvate, SS-B/La.
1:14
Examples of antigens to
extracellular membrane-bound antigens include acetylcholine receptor, aquaporin 4,
phospholipase A2, desmoglein I and III, thyrotropin receptor antibody,
glycoproteins IIb-IIIa or Ib-IX from platelets,
and the proton pump and intrinsic factor in gastric mucosa.
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