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Pathogenic mechanisms of autoantibodies: antibodies to intracellular and membrane-bound antigens

Part 2 of 2
Published on June 30, 2020   34 min

A selection of talks on Clinical Practice

0:00
My name is Luis Andrade. I am an Associate Professor of Medicine at Universidade Federal De São Paulo, Brazil, Medical Consultant for Immunology at the Fleury Laboratory and Chair of the Quality Standardization and Assessment Committee of the IUIS. In the second part of the talk on pathogenic mechanisms of autoantibodies, I will focus on antibodies to intracellular antigens and to membrane-bound antigens and discuss possible pathogenic mechanisms for these two classes of autoantibodies.
0:43
At this point, it is important to consider that we have two classes of autoantigens; intracellular and extracellular antigens. Antibodies to intracellular antigens include chromatin antigen, spliceosome antigens, DNA topoisomerase 1, tRNA synthetases, liver kidney microsome, mitochondria pyruvate, SS-B/La.
1:14
Examples of antigens to extracellular membrane-bound antigens include acetylcholine receptor, aquaporin 4, phospholipase A2, desmoglein I and III, thyrotropin receptor antibody, glycoproteins IIb-IIIa or Ib-IX from platelets, and the proton pump and intrinsic factor in gastric mucosa.
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Pathogenic mechanisms of autoantibodies: antibodies to intracellular and membrane-bound antigens

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