My name is Luis Andrade.
I am an Associate Professor of Medicine at Universidade Federal De São Paulo, Brazil,
Medical Consultant for Immunology at the Fleury Laboratory and
Chair of the Quality Standardization and Assessment Committee of the IUIS.
In the second part of the talk on pathogenic mechanisms of autoantibodies,
I will focus on antibodies to intracellular antigens and to
membrane-bound antigens and discuss
possible pathogenic mechanisms for these two classes of autoantibodies.
At this point, it is important to consider that we have two classes of autoantigens;
intracellular and extracellular antigens.
Antibodies to intracellular antigens include chromatin antigen, spliceosome antigens,
DNA topoisomerase 1, tRNA synthetases,
liver kidney microsome, mitochondria pyruvate, SS-B/La.
Examples of antigens to
extracellular membrane-bound antigens include acetylcholine receptor, aquaporin 4,
phospholipase A2, desmoglein I and III, thyrotropin receptor antibody,
glycoproteins IIb-IIIa or Ib-IX from platelets,
and the proton pump and intrinsic factor in gastric mucosa.