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Hello, my name is Luis Andrade.
I am an Associate Professor at Universidade Federal de Sao Paulo in Brazil.
I am also a medical consultant in immunology at Fleury Laboratory
and the Chair of the Quality Assessment and Standardization Committee at IUIS.
Today, we're going to talk about pathogenic mechanisms of autoantibodies.
In this lecture, I will show how autoantibodies
have been instrumental to the establishment of
the concept of autoimmunity and to the shaping of
the clinical spectrum of several autoimmune diseases.
Then I will explore the possible reasons for
the tight association between autoantibodies and autoimmune diseases.
Finally, I will explore the several mechanisms by
which autoantibodies play a pathogenic role.
Along the millennia, medicine has been going through
a continuous evolution in conceptual paradigms.
In ancient medicine, there was a prevailing supernatural and mystical paradigm.
Progressively, the conceptual paradigm evolved on
the basis of rational and objective exploration and experimentation,
and the establishment of
a scientific paradigm,
that contributed to the development of the current classification of
diseases and establishment of laboratory biomarkers for diagnosis and
monitoring, as well as the guiding for clinical examination.