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Pathogenic mechanisms of autoantibodies: circulating and local antibodies that form immune complexes
Published on June 30, 2020 20 min
A selection of talks on Clinical Practice
Trauma-informed care (TIC)
- Dr. Gina Touch Mercer
- University of Arizona College of Medicine - Phoenix, USA
The history and foundations of medical research ethics
- Prof. Dr. Christian Lenk
- Ulm University, Germany
Hello, my name is Luis Andrade. I am an Associate Professor at Universidade Federal de Sao Paulo in Brazil. I am also a medical consultant in immunology at Fleury Laboratory and the Chair of the Quality Assessment and Standardization Committee at IUIS. Today, we're going to talk about pathogenic mechanisms of autoantibodies.
In this lecture, I will show how autoantibodies have been instrumental to the establishment of the concept of autoimmunity and to the shaping of the clinical spectrum of several autoimmune diseases. Then I will explore the possible reasons for the tight association between autoantibodies and autoimmune diseases. Finally, I will explore the several mechanisms by which autoantibodies play a pathogenic role.
Along the millennia, medicine has been going through a continuous evolution in conceptual paradigms.
In ancient medicine, there was a prevailing supernatural and mystical paradigm.
Progressively, the conceptual paradigm evolved on the basis of rational and objective exploration and experimentation, and the establishment of a scientific paradigm,
that contributed to the development of the current classification of diseases and establishment of laboratory biomarkers for diagnosis and monitoring, as well as the guiding for clinical examination.