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Hello, my name is Luis Andrade.
I am an Associate Professor at Universidade Federal de Sao Paulo in Brazil.
I am also a medical consultant in immunology at Fleury Laboratory
and the Chair of the Quality Assessment and Standardization Committee at IUIS.
Today, we're going to talk about pathogenic mechanisms of autoantibodies.
0:27
In this lecture, I will show how autoantibodies
have been instrumental to the establishment of
the concept of autoimmunity and to the shaping of
the clinical spectrum of several autoimmune diseases.
Then I will explore the possible reasons for
the tight association between autoantibodies and autoimmune diseases.
Finally, I will explore the several mechanisms by
which autoantibodies play a pathogenic role.
0:55
Along the millennia, medicine has been going through
a continuous evolution in conceptual paradigms.
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In ancient medicine, there was a prevailing supernatural and mystical paradigm.
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Progressively, the conceptual paradigm evolved on
the basis of rational and objective exploration and experimentation,
and the establishment of
a scientific paradigm,
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that contributed to the development of the current classification of
diseases and establishment of laboratory biomarkers for diagnosis and
monitoring, as well as the guiding for clinical examination.