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Pathogenic mechanisms of autoantibodies: circulating and local antibodies that form immune complexes

Part 1 of 2
Published on June 30, 2020   20 min

A selection of talks on Clinical Practice

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0:00
Hello, my name is Luis Andrade. I am an Associate Professor at Universidade Federal de Sao Paulo in Brazil. I am also a medical consultant in immunology at Fleury Laboratory and the Chair of the Quality Assessment and Standardization Committee at IUIS. Today, we're going to talk about pathogenic mechanisms of autoantibodies.
0:27
In this lecture, I will show how autoantibodies have been instrumental to the establishment of the concept of autoimmunity and to the shaping of the clinical spectrum of several autoimmune diseases. Then I will explore the possible reasons for the tight association between autoantibodies and autoimmune diseases. Finally, I will explore the several mechanisms by which autoantibodies play a pathogenic role.
0:55
Along the millennia, medicine has been going through a continuous evolution in conceptual paradigms.
1:03
In ancient medicine, there was a prevailing supernatural and mystical paradigm.
1:11
Progressively, the conceptual paradigm evolved on the basis of rational and objective exploration and experimentation, and the establishment of a scientific paradigm,
1:25
that contributed to the development of the current classification of diseases and establishment of laboratory biomarkers for diagnosis and monitoring, as well as the guiding for clinical examination.

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Pathogenic mechanisms of autoantibodies: circulating and local antibodies that form immune complexes

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