Registration for a live webinar on 'Innate immunity, inflammation and cancer' is now open.
See webinar details
This is a limited length demo talk; you may
login or
review methods of
obtaining more access.
- General Virology
-
46 min
1. Principles of virology- Prof. Vincent Racaniello
-
36 min
2. Antiviral drugs (non-HIV)- Prof. Megan Shaw
-
36 min
3. The type I interferon system and viruses- Dr. Adolfo Garcia-Sastre
-
45 min
4. Immune responses to viruses- Prof. Paul Klenerman
- Emerging Pathogens
-
29 min
5. Emerging or newly discovered viral causes of acute lower respiratory tract infections worldwide- Dr. Marietjie Venter
- Mrs. Orienka Hellferscee
-
37 min
6. Emerging respiratory viruses - discoveries between 2001 and 2005- Prof. Ron Fouchier
-
28 min
7. Usage of vaccines and therapeutics in public health emergencies 1- Prof. Gary Kobinger
-
39 min
8. Usage of vaccines and therapeutics in public health emergencies 2- Prof. Gary Kobinger
-
50 min
9. Influenza virus pandemics: past and future- Prof. Peter Palese
-
63 min
10. SARS-CoV and other emerging coronaviruses- Prof. Ralph Baric
-
36 min
11. Dengue, Zika and Chickungunya viruses- Prof. Ana Fernandez-Sesma
-
41 min
12. Biodefense challenges- Dr. David Franz
- Important Pathogens and their Diseases
-
38 min
13. Natural history and pathogenesis of herpes virus infections- Prof. Richard Whitley
-
40 min
14. Cytomegalovirus biology- Prof. Domenico Tortorella
-
46 min
15. Hepatitis C virus: discovery, cure and protection- Dr. Matthew Evans
-
32 min
16. Fundamentals of HIV biology- Prof. Viviana Simon
-
44 min
17. Measles- Prof. Diane E. Griffin
- New Frontiers
-
45 min
-
55 min
-
30 min
20. Viruses as anticancer weapons- Prof. Roberto Cattaneo
-
48 min
21. Novel approaches to diagnosis of viral infections- Prof. W. Ian Lipkin
-
31 min
22. Elite controllers of HIV: from discovery to future therapies- Prof. Bruce Walker
- Archived Lectures *These may not cover the latest advances in the field
-
43 min
23. Principles of virology I- Prof. Richard Condit
-
43 min
24. Principles of virology II- Prof. Richard Condit
-
36 min
25. Complex DNA viruses: herpes virus- Dr. John Blaho
-
38 min
26. Adeno-associated viruses (AAV)- Prof. Kenneth Berns
-
60 min
27. Poxviruses: smallpox (variola), vaccinia and monkeypox- Prof. Paula Traktman
-
26 min
28. Can HPV testing be the sole primary cervical screening modality?- Prof. Jack Cuzick
-
29 min
29. From viruses to oncolytics- Prof. Roberto Cattaneo
-
38 min
30. Non HIV antivirals- Prof. Mary Klotman
-
42 min
31. Gastroenteritis viruses- Prof. Mary Estes
-
46 min
32. Biodefense challenges- Dr. Connie Schmaljohn
-
32 min
-
49 min
34. The past, present and future of vaccination- Prof. Stanley Plotkin
-
41 min
35. Filoviruses- Dr. Christopher Basler
-
41 min
36. Bunyaviruses- Prof. Richard Elliott
-
41 min
37. The immunobiology of HIV- Prof. Norman Letvin
-
59 min
38. Hepatitis C and HCV- Prof. Stanley Lemon
Printable Handouts
Navigable Slide Index
- Introduction
- Outline of the lecture
- Characteristics of the family Bunyaviridae
- Bunyaviridae genera
- Principal Bunyavirus vectors
- Cryoelectron microscopy of a Bunyavirus
- Bunyavirus virion structure
- Disease syndromes associated with Bunyaviridae
- Oropouche Orthobunyavirus
- La Crosse Orthobunyavirus
- Hantaviruses
- Hantaviruses in the old world
- Hantavirus pulmonary syndrome
- New world Hantaviruses
- Rift valley fever Phlebovirus
- Crimean-Congo haemorrhagic fever virus
- Life-cycle of mosquito transmitted Orthobunyavirus
- Virus is present in all stages of mosquito life cycle
- Scanning EM of mosquito proboscis
- Bunyavirus cycles
- Transmission and maintenance cycles of the virus
- Vector competence
- Bunyavirus evolution
- Bunyavirus reassortment
- Occurrence of bunyaviruses reassortment
- Bunyavirus reassortants
- Garissa/Ngari virus
- Orthobunyavirus replication
- Replication of Bunyamwera virus in mosquito cells
- Time course of viral protein synthesis
- Transcription and replication of viral genome
- Bunyavirus minireplicon system
- Viral vector expression in the minireplicon system
- Bunyavirus rescue: 3 plasmids
- Creation of BUN MLM virus
- BUN MLM virus forms small plaques
- BUN MLM virus makes less L protein
- BUN MLM virus packages less L segment RNA
- BUN MLM virus has high particle:pfu ratio
- BUN MLM virus is attenuated in mice
- Orthobunyavirus S segment coding strategy
- Deletion of BUNV NSs protein
- Production of Bunyamwera virus lacking NSs
- NSs is an interferon antagonist (1)
- Interferon induction by BUNdelNSs
- NSs is an interferon antagonist (2)
- Summary of BUNdelNSs characteristics
- Host cell shutoff by BUNdelNSs - mammalian cells
- Monitoring shut-off in BUNV infected cells
- Independent ability of NSs to cause shut-off
- Dose dependant manner of shut-off by NSs
- NSs and host cell shut-off
- NSs has an effect on RNA polymerase II levels
- How does NSs mediate its effect?
- NSs-Med8 interaction
- Med8 is a component of mediator
- Mapping the interaction on NSs
- Importance of C-terminus of NSs
- Effect of truncated NSs on host protein shut-off
- Effect of truncated NSs on RNA Pol II levels
- Effect of truncated NSs on IFN-beta promoter
- Induction of IFNbeta mRNA by NSs-mutant viruses
- Conclusions about NSs
- Function of NSs in mosquito cells
- What about other Bunyaviruses?
- Rift Valley fever virus NSs protein
Topics Covered
- Classification of bunyaviruses
- Diseases caused by bunyaviruses
- Natural history of bunyaviruses
- Bunyavirus evolution
- Bunyavirus replication
- Bunyavirus reverse genetics
- Bunyaviruses and the host innate immune response
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Elliott, R. (2007, October 1). Bunyaviruses [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 19, 2024, from https://hstalks.com/bs/366/.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Richard Elliott has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
