• General Virology
• 46 min
  1. Principles of virology

  • Prof. Vincent Racaniello
• 36 min
  2. The type I interferon system and viruses

  • Dr. Adolfo Garcia-Sastre
• 45 min
  3. Immune responses to viruses

  • Prof. Paul Klenerman
• Emerging Pathogens
• 29 min
  4. Emerging or newly discovered viral causes of acute lower respiratory tract infections worldwide

  • Dr. Marietjie Venter
  • Mrs. Orienka Hellferscee
• 37 min
  5. Emerging respiratory viruses - discoveries between 2001 and 2005

  • Prof. Ron Fouchier
• 28 min
  6. Usage of vaccines and therapeutics in public health emergencies 1

  • Prof. Gary Kobinger
• 39 min
  7. Usage of vaccines and therapeutics in public health emergencies 2

  • Prof. Gary Kobinger
• 50 min
  8. Influenza virus pandemics: past and future

  • Prof. Peter Palese
• 63 min
  9. SARS-CoV and other emerging coronaviruses

  • Prof. Ralph Baric
• 36 min
  10. Dengue, Zika and Chickungunya viruses

  • Prof. Ana Fernandez-Sesma
• 43 min
  11. Paramyxoviruses: biology & pathogenesis

  • Prof. Benhur Lee
• 36 min
  12. Antiviral drugs (non-HIV)

  • Prof. Megan Shaw
• 41 min
  13. Biodefense challenges

  • Dr. David Franz
• Important Pathogens and their Diseases
• 38 min
  14. Natural history and pathogenesis of herpes virus infections

  • Prof. Richard Whitley
• 40 min
  15. Cytomegalovirus biology

  • Prof. Domenico Tortorella
• 46 min
  16. Hepatitis C virus: discovery, cure and protection

  • Dr. Matthew Evans
• 32 min
  17. Fundamentals of HIV biology

  • Prof. Viviana Simon
• 44 min
  18. Measles

  • Prof. Diane E. Griffin
• 42 min
  19. Monkeypox virus, vaccines, and therapeutics

  • Prof. Rachel Roper
• New Frontiers
• 45 min
  20. HPV vaccines to prevent cervical cancer and other HPV-associated diseases

  • Dr. John Schiller
• 55 min
  21. Prevention of Varicella and Zoster by vaccination: Now you see it, now you don't

  • Prof. Anne Gershon
• 30 min
  22. Viruses as anticancer weapons

  • Prof. Roberto Cattaneo
• 48 min
  23. Novel approaches to diagnosis of viral infections

  • Prof. W. Ian Lipkin
• 36 min
  24. The Global Virus Network: collaboration to address pandemic and regional threats

  • Prof. Sten H. Vermund
• 31 min
  25. Elite controllers of HIV: from discovery to future therapies

  • Prof. Bruce Walker
• Archived Lectures *These may not cover the latest advances in the field
• 43 min
  26. Principles of virology I

  • Prof. Richard Condit
• 43 min
  27. Principles of virology II

  • Prof. Richard Condit
• 36 min
  28. Complex DNA viruses: herpes virus

  • Dr. John Blaho
• 38 min
  29. Adeno-associated viruses (AAV)

  • Prof. Kenneth Berns
• 60 min
  30. Poxviruses: smallpox (variola), vaccinia and monkeypox

  • Prof. Paula Traktman
• 26 min
  31. Can HPV testing be the sole primary cervical screening modality?

  • Prof. Jack Cuzick
• 29 min
  32. From viruses to oncolytics

  • Prof. Roberto Cattaneo
• 38 min
  33. Non HIV antivirals

  • Prof. Mary Klotman
• 42 min
  34. Gastroenteritis viruses

  • Prof. Mary Estes
• 46 min
  35. Biodefense challenges

  • Dr. Connie Schmaljohn
• 32 min
  36. Papillomaviruses and HPV vaccination to prevent cervical cancer and other HPV-associated diseases

  • Dr. Douglas Lowy
• 49 min
  37. The past, present and future of vaccination

  • Prof. Stanley Plotkin
• 41 min
  38. Filoviruses

  • Dr. Christopher Basler
• 41 min
  39. Bunyaviruses

  • Prof. Richard Elliott
• 41 min
  40. The immunobiology of HIV

  • Prof. Norman Letvin
• 59 min
  41. Hepatitis C and HCV

  • Prof. Stanley Lemon

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Outline of the lecture
3. Characteristics of the family Bunyaviridae
4. Bunyaviridae genera
5. Principal Bunyavirus vectors
6. Cryoelectron microscopy of a Bunyavirus
7. Bunyavirus virion structure
8. Disease syndromes associated with Bunyaviridae
9. Oropouche Orthobunyavirus
10. La Crosse Orthobunyavirus
11. Hantaviruses
12. Hantaviruses in the old world
13. Hantavirus pulmonary syndrome
14. New world Hantaviruses
15. Rift valley fever Phlebovirus
16. Crimean-Congo haemorrhagic fever virus
17. Life-cycle of mosquito transmitted Orthobunyavirus
18. Virus is present in all stages of mosquito life cycle
19. Scanning EM of mosquito proboscis
20. Bunyavirus cycles
21. Transmission and maintenance cycles of the virus
22. Vector competence
23. Bunyavirus evolution
24. Bunyavirus reassortment
25. Occurrence of bunyaviruses reassortment
26. Bunyavirus reassortants
27. Garissa/Ngari virus
28. Orthobunyavirus replication
29. Replication of Bunyamwera virus in mosquito cells
30. Time course of viral protein synthesis
31. Transcription and replication of viral genome
32. Bunyavirus minireplicon system
33. Viral vector expression in the minireplicon system
34. Bunyavirus rescue: 3 plasmids
35. Creation of BUN MLM virus
36. BUN MLM virus forms small plaques
37. BUN MLM virus makes less L protein
38. BUN MLM virus packages less L segment RNA
39. BUN MLM virus has high particle:pfu ratio
40. BUN MLM virus is attenuated in mice
41. Orthobunyavirus S segment coding strategy
42. Deletion of BUNV NSs protein
43. Production of Bunyamwera virus lacking NSs
44. NSs is an interferon antagonist (1)
45. Interferon induction by BUNdelNSs
46. NSs is an interferon antagonist (2)
47. Summary of BUNdelNSs characteristics
48. Host cell shutoff by BUNdelNSs - mammalian cells
49. Monitoring shut-off in BUNV infected cells
50. Independent ability of NSs to cause shut-off
51. Dose dependant manner of shut-off by NSs
52. NSs and host cell shut-off
53. NSs has an effect on RNA polymerase II levels
54. How does NSs mediate its effect?
55. NSs-Med8 interaction
56. Med8 is a component of mediator
57. Mapping the interaction on NSs
58. Importance of C-terminus of NSs
59. Effect of truncated NSs on host protein shut-off
60. Effect of truncated NSs on RNA Pol II levels
61. Effect of truncated NSs on IFN-beta promoter
62. Induction of IFNbeta mRNA by NSs-mutant viruses
63. Conclusions about NSs
64. Function of NSs in mosquito cells
65. What about other Bunyaviruses?
66. Rift Valley fever virus NSs protein

Topics Covered

• Classification of bunyaviruses
• Diseases caused by bunyaviruses
• Natural history of bunyaviruses
• Bunyavirus evolution
• Bunyavirus replication
• Bunyavirus reverse genetics
• Bunyaviruses and the host innate immune response

Links

Series:

• Viruses and Viral Diseases

Categories:

• Microbiology

Therapeutic Areas:

• Infectious Diseases

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on October 28, 2018

Financial Disclosures

• Prof. Richard Elliott has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.