The genetics of glioblastoma

Published on December 31, 2015   26 min

Other Talks in the Series: Cancer Genetics

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Hello and welcome to this talk entitled The Genetics of Glioblastoma as part of the Henry Stewart Talks on the genetics of cancers. My name is Dr. Hai Yan. I am the Henry Friedman Professor of Neuro Oncology at Duke University where I reside as a member of the Department of Pathology under Preston Robert Tisch Brain Tumor Center.
It is my privilege to discuss this content matter with you today that honors the work of people before me such as doctors Henry Friedman, Darell Bigner, Bert Vogelstein and many other major contributors to the field of brain cancer research. Naturally, I will also include some summaries of some of the work I have contributed to this important field. This work outlines the approach many scientists take to making further discoveries for aid in understanding and the treatment of what is a terribly deadly disease. Let's get started.
I will break this talk down into three sections that go through and involving depths of detail into the genetics of glioblastoma. While the majority of this talk will highlight the most updated, presented work in the field, I will also spend some time providing a brief summary of glioma and the hierarchy by which we classified them. I will then explain to the extent if possible how and why the use of genetics impacts the brain cancer research and treatment. This field is a critically important work to solving the confused cells, rogue in their behavior as tumors and deadly in their impact on people. Lastly, I attempt to capture just how we use genomic research by using some compounding stories along the way. The featured is that of isocitrate dehydrogenase better referred to as IDH. A curious insight into how one genomic finding can unpack a wealth of knowledge about the mischievous inner workings of cancer cells. Finally, I'd like to share with you the very cutting-edge of genomic research by discussing a mutation we discovered just two years ago called TERT. I hope you enjoy the discussion. Now let's begin.