Functional cancer genomics

Published on October 29, 2015   44 min

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Other Talks in the Series: Cancer Genetics

Hello. I am Roderick Beijersbergen from the Netherlands Cancer Institute in Amsterdam. And I will be talking to you today about functional cancer genomics.
In the past decade, rapid progress in the ability to analyze full genomes of cancers has pointed out that individual tumors may contain hundreds and thousand of mutations across the entire genome. Some tumors, such as colorectal cancer, lung cancer and melanoma, have frequently even up to a 100,000 mutations. Although the majority of these mutations will not directly affect the coding region of genes, and thus, not lead to abnormal proteins, estimates are that 10 to 100 mutations expressed in coding regions will result in the expression of mutant proteins with aberrant functions. These abnormal proteins and the biological pathways and mechanisms they control play important roles in the development of cancer and response to cancer therapies. It's an enormous challenge for oncology research to map and understand the role of each of these genetic alterations for the diagnosis, prognosis and treatment of cancer. In addition to the large numbers of mutations found in different tumor types, it has also become clear that within one tumor type, for example lung cancer, different mutational spectra can be found in individual patients.