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Hello, I'm Sharon Marsh
from the University of Albertain Edmonton, Canada.And this lecture
is on Pharmacogenomicsin Cancer Therapy.
First, we will go through some
background on pharmacogenomics.Then we'll discuss the typesand sources
of genetic variation.We will discuss the techniquesused to measure
genetic variation.And then we will go throughexamples of cancer
pharmacogenomicsand drug selection,drug toxicity and drug outcomes.And then we will
summarize the lecture.We will now
discuss the backgroundto cancer pharmacogenomics.
As you can see from this slide,adverse drug reactions
are a significant problemto the healthcare system.Adverse drug reactions area reaction
to the medication itself,not the disease
that the medicationis trying to treat.This can be particularly
problematic in cancer patientswhere the therapeutic window
for treatment is very narrow.Reduction in dosage
or reduction of medicationor removal of medication
can be detrimentaland potentially fatalif this has to occur
due to an adverse reaction.
So what are the causes
of individual variabilityin drug response?They are many.They range from the environment,
concurrent medications, stress,smoking status, age,
diet and exercise,metabolic issues
and, of course, genetics.Although genetics
can play a major rolein drug disposition
and response,it is by far
not the only explanationfor failure of a medication
or for an adverse drug reaction.And it needs to be
taken into accountthat genetics will never
be able to explain 100 percentof all of the variability
in drug response.