Molecular genetics of non-Hodgkin lymphoma

Published on November 30, 2015   33 min

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Other Talks in the Series: Cancer Genetics

My name is Jude Fitzgibbon. I am a Professor in Personalized Cancer Medicine at the Barts Cancer Institute. It's part of Queen Mary University of London. My lecture today is on the Molecular Genetics of Non-Hodgkin Lymphoma. I am going to be using an indolent B-cell malignancy called follicular lymphoma as an example.
I think it's important to preset that cancer represents almost the perfect genetic disease where it's radicalized maybe 10-20 genes to actually shift the balance from a normalcy to a malignant phenotype. And so we need to think of these genes as individuals but also how they kind of work together to cooperate to actually drive this change in phenotype. And it's helpful to think of a formula in relationship to cancer and indeed B-cell malignancy in relationship to the genetics and the microenvironment working together to give rise to cancer.
The technology has improved fantastically. When I started my PhD in the late '80s, you know, I did my first polymerase chain reaction, my first PCRs using three water baths set at different temperatures, a stopwatch, and a tweezers to actually move the chews from one place to another. Now we've got the opportunity to actually sample all genes, all DNA in one single experiment and monitor their expression at the same time.

Molecular genetics of non-Hodgkin lymphoma

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