The non-coding RNA revolution in the cancer society

Published on November 30, 2015   47 min

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Other Talks in the Series: Cancer Genetics

Hello to everybody. As usual, it's my pleasure to present to you what I like to do more after playing with my kids, playing with microRNAs and non-coding RNAs. My name is George Calin, I'm a professor in MD Anderson Cancer Center and I will tell you today about the non-coding RNA revolution in the cancer society.
Basically what is new and what is wonderful in science is the fact that you never know what the next day is bringing you. Genomics was bringing to the scientists working in this field basically the so-called Dark Matter. It's a part of the genome that is not transcribed in protein coding genes. So therefore was supposed to be the trash can of the genome. By analyzing data and by analyzing transcripts, in this place where nobody was looking for, starting about two decades again, genetics turned around and basically now it's full of over 1 million so-called non-coding RNAs. These RNAs who did not codify or proteins but regulates this expression of protein coding genes, and this is the main topic of my presentation today.
Basically, the dogma of molecular biology was very simple, and everybody was believing this is final truth of genomics. DNA is the most important, is transcribed in RNAs who are translated to proteins. RNAs were considered intermediary of genetic flow, so very few people were interested in understanding how really RNA was working. There were some flagging discovery showing that RNAs are not bystanders in the dogma like the identification of ribozymes or the identification of editing, but still RNAs were considered secondary player in the game.

The non-coding RNA revolution in the cancer society

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