Human genetic variation and the genotype-phenotype problem 2

Published on July 30, 2015   20 min

Other Talks in the Series: Topical Talks

0:04
Parallel to Weldon, who is quoted on the bottom of the slide, stating that, The accumulation of records, in which results are massed together in ill-defined categories of variable and uncertain extent, can only result in harm. This is also very much reflected in the writings of this other individual, Seguin, in 1866, where he said, Our incomplete studies do not permit actual classification; but is better to leave things by themselves rather than to force them into classes which have their foundation only on paper. And my own training in clinical psychiatry that went from 2004 until 2009 reflected this as well. The DSM categorization of psychiatric disorders is, frankly, not much better than where things stood in 1866. And we are massively ignorant concerning the true uniqueness of the complexity of many different illnesses, including illnesses affecting the brain.
1:03
Another famous individual was Dr. Down, or Langdon Down, who first discovered Down's Syndrome. And, hence, the syndrome is named after Dr. Down, wrote this very prescient comments in 1866 that, Those who have given any attention to congenital mental lesions must have been frequently puzzled how to arrange, in any satisfactory manner, the different classes of this defect, which may have come under their observation. Nor will the difficulty be lessened by an appeal to what has been written on the subject. These systems of classification are generally so vague and artificial that not only do they assist but feebly, in any mental arrangement of the phenomena represented, but they completely fail in exerting any practical influence on the subject. And I've said already, in the year 2015, I would argue that the current categorization schema or mental illness are frankly really not much better than they were in 1866.
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Human genetic variation and the genotype-phenotype problem 2

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