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0:00
In this lecture, I will tell
you about the discovery,
the etiology, and
the critical aspects
of what is called
Laron Syndrome (LS).
My experience is about 60 years,
as I will show you.
0:22
In 1958, at a time when
no assay from human growth
hormone was available,
three siblings, aged three,
one and a newborn baby,
were referred to me.
Two of those are shown
on the left panel.
They belong to a consanguineous
Jewish family of
the Yemenite origin,
seen in the right panel.
Five older siblings
were of normal stature.
0:54
Their appearance was dwarfism,
obesity, acromicria,
hypogenitalism, and
severe hypoglycemia,
which resembled children with
pituitary isolated growth
hormone deficiency.
When comparing the gender, one
who is LS on the left
side, with a same aged
boy with isolated growth
hormone deficiency,
we see their great resemblance.
However, they are smaller
than the patient with
growth hormone deficiency,
denoting already the lack of
efficiency of this hormone.
1:37
In the early 1960s, when
radioimmunoassays for growth
hormone became available,
we found to our
great surprise that
the circulating hGH was very
high reaching acromegalic
levels, as seen in the left,
up to 140 ng/ml.
On the right, we see
the night secretion of
growth hormone with
very high peaks in
the LS patients as compared to
a normal control of the same
age, in the lower side.