Registration for a live webinar on 'Innovative Vaccines and Viral Pathogenesis: Insights from Recent Monkeypox Research' is now open.
See webinar detailsWe noted you are experiencing viewing problems
-
Check with your IT department that JWPlatform, JWPlayer and Amazon AWS & CloudFront are not being blocked by your network. The relevant domains are *.jwplatform.com, *.jwpsrv.com, *.jwpcdn.com, jwpltx.com, jwpsrv.a.ssl.fastly.net, *.amazonaws.com and *.cloudfront.net. The relevant ports are 80 and 443.
-
Check the following talk links to see which ones work correctly:
Auto Mode
HTTP Progressive Download Send us your results from the above test links at access@hstalks.com and we will contact you with further advice on troubleshooting your viewing problems. -
No luck yet? More tips for troubleshooting viewing issues
-
Contact HST Support access@hstalks.com
-
Please review our troubleshooting guide for tips and advice on resolving your viewing problems.
-
For additional help, please don't hesitate to contact HST support access@hstalks.com
We hope you have enjoyed this limited-length demo
This is a limited length demo talk; you may
login or
review methods of
obtaining more access.
Printable Handouts
Navigable Slide Index
- Introduction
- Earth as a petri dish
- The earth is 4.5 billion years old
- Population stratification from migration patterns
- Humans are mosaics
- Darwin, Mendel, Galton
- Pearson, Weldon, Bateson
- The first two generations of genetics researchers
- Galton and Pearson
- Beyond our Kuhnian inheritance
- Weldon paper on Mendel's experiments
- Weldon's point of view
- Walter Frank Raphael Weldon - A memoir
- Biological indeterminacy
- Biological robustness
- Lenski's parallel evolution experiment
- Genotype does not equal phenotype
- Categorical thinking misses complexity
- Genotype-phenotype correlations: model
- Penetrance and expressivity
- Expression issues
- Hogben and Fisher
- Books on nature and nurture
- Cretinism
- Down syndrome (1)
- Down syndrome (2)
- Velocardiofacial syndrome
- “Superpower” mutations?
- Myostatin mutation
- "Belgian Blue" cattle
- Dog example of myostatin
- Ogden syndrome (1)
- Ogden syndrome (2)
- Ogden syndrome (3)
- Ogden syndrome (4)
- Identifying disease mutation - 2012 paper
- Human genetics and neurodevelopment - 2015 paper
- The genetics of neurodevelopmental disorders - book
Topics Covered
- Humans as mosaics
- Biological indeterminacy & robustness
- Parallel evolution
- Genotype vs. phenotype
- Categorical thinking misses complexity
- Penetrance and expressivity
- Nature and nurture
- “Superpower” mutations
- Identifying disease mutations
- Genetics of neurodevelopmental disorders
- Discovery of families with rare diseases and/or increased prevalence for syndromes
- Genetic background and environmental perturbation influence phenotypic differences in severe mental illness
Talk Citation
Lyon, G. (2015, July 30). Human genetic variation and the genotype-phenotype problem 1 [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 12, 2024, from https://doi.org/10.69645/QCHL3938.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Gholson Lyon has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Human genetic variation and the genotype-phenotype problem 1
Published on July 30, 2015
33 min
A selection of talks on Genetics & Epigenetics
Transcript
Please wait while the transcript is being prepared...
0:00
Hello, my
name is Gholson Lyon,
and I'm on faculty at Cold
Spring Harbor Laboratory
as well as working at the Utah
Foundation for Biomedical Research.
And the topic of my lecture today
is on human genetic variation
and genotype-phenotype problem.
0:18
This is an illustration of
the earth, and on the right
side is an illustration
of a bacterial petri dish.
0:27
The earth is 4.5 billion years old.
And in the eons of time, there
are dinosaurs that basically
went extinct 65 million years ago.
And you can look at
dinosaur fossils at the Utah
Dinosaur National Monument as
illustrated in this illustration.
And if you want to be convinced
that dinosaurs existed,
you can look yourself at them in the
rocks before they were excavated.
And the only reason I'm
telling you this in the context
of human genetics is basically just
to illustrate to you that there is
an enormous amount of
time that has passed
and that evolution is operating
on the order of millions of years.
Also, if you want further proof
of dinosaurs having gone extinct,
there's the Yucatan Peninsula.
There's evidence there
of a crater where
a meteor hits and basically caused
the extinction of the dinosaurs.
So since the extinction
of the dinosaurs,
there was basically
many millions of years.
1:36
So this slide illustrates
the fact that humans
originate and migrate out of Africa
approximately 100,000 years ago.
And as shown in this
illustration, various homo sapien
species migrated and
populated parts of the world,
including crossing the Bering
Strait sometime between 15,000
to 35,000 years ago and then making
their way down into South America.
And I further illustrate
on this slide, the fact
that there's been an enormous amount
of time with many, many generations
in which case there's been many
different meiotic events thus
leading to much
population stratification.
And this population
stratification is
from the migration
patterns of haplotypes
throughout human history.