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Printable Handouts
Navigable Slide Index
- Introduction
- Strategies to sense pathogens & damaged tissues
- Complement system activation & regulation
- Complement system activation pathways (1)
- Evolutionary perspective of the complement system
- Complement system activation pathways (2)
- Results of complement system activation
- Domain and structure of MBL & ficolin (1)
- Carbohydrate pattern recognition by MBP
- Domain and structure of MBL & ficolin (2)
- Domain structure of the MASP family
- Collectins: Players of the innate immune system
- Lung collectins: Dual function surveillance
- Pattern recognition molecules and cell receptors
- Cascade of inflammatory cytokines
- Main acute phase proteins
- General significance of the acute phase response
- The IL-1 receptor (ILR) superfamily
- Schematic representation of IL-1’s role in immunity
Topics Covered
- Sensing pathogens and damaged tissues
- Complement system activation and regulation
- The classical, lectin, and alternative pathways
- The MASP family
- Collectins
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Mantovani from humanitas.it, A. (2016, August 31). Humoral innate immunity and the acute phase response 1 [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 9, 2024, from https://doi.org/10.69645/ZFRH2377.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Alberto Mantovani, Grant/Research Support (Principal Investigator): SIGMA-TAU, ROME
Humoral innate immunity and the acute phase response 1
A selection of talks on Immunology
Transcript
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0:00
This presentation
will be focused
on the Humoral arm of the
Innate Immunity
and the Acute Phase Response
will be discussed in the context
and in the perspective
of fluid phase
humoral pattern
recognition molecules.
0:20
The innate immune system
includes a cellular
and a humoral arm.
Cell associated
pattern recognition molecules
are strategically located
on the cell surface
the Toll-like receptors
and co-receptors shown here
are also located
in the endosomal compartment,
a subset of the Toll-like receptor
and in the cytoplasm.
The latter include
NOD-like receptors,
RIG-like receptors
and not shown here,
AIM-like receptors.
This is where all the hype is,
cellular innate immunity.
But the innate immune system
also includes a humoral arm
which is generally represented
as a collection of weird molecules.
Humoral pattern
recognition molecules
include ficolins, collectins
such as mannose-binding lectin
and surfactant protein A and D.
Components of the complement
cascade and
short and long interactions.
In this presentation, I will focus
on the humoral arm
of the innate immunity
and on the humoral
pattern recognition molecules.
Using in particular, pentraxins
and along pentraxin PTX3,
as a paradigm for the logic
and the mode of action
and interplay
of the cellular innate immunity
of the humoral fluid phase
pattern recognition molecules.