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- Models of Investigation
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41 min
1. Antifungal innate immunity in C. elegans- Dr. Jonathan Ewbank
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44 min
2. The anti-microbial defense of Drosophila: a paradigm for innate immunity- Prof. Jules Hoffmann
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38 min
3. Phagocytosis in the fruit fly, Drosophila melanogaster- Dr. Lynda Stuart
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62 min
4. Innate immune sensing and response- Prof. Bruce Beutler
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61 min
5. Macrophages and systems biology- Prof. David Hume
- Cell Types and Recruitment
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71 min
6. Leukocyte recruitment in vivo- Prof. Paul Kubes
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51 min
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42 min
8. Eosinophils- Prof. Tim Williams
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63 min
9. Dendritic cells: linking innate to different forms of adaptive immunity- Prof. Ralph Steinman
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25 min
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61 min
11. Innate-like lymphocytes 1- Prof. Adrian Hayday
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41 min
12. Innate-like lymphocytes 2- Prof. Adrian Hayday
- Recognition and Signaling
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50 min
13. Colony stimulating factor-1 regulation of macrophages in development and disease- Prof. E. Richard Stanley
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42 min
14. Fc receptors: linking innate and acquired immunity- Prof. Ken G C Smith
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39 min
15. Phagocytosis- Prof. Joel Swanson
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44 min
16. Clearance of apoptotic cells and the control of inflammation- Prof. Sir John Savill
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38 min
17. Signaling by innate immune receptors- Prof. Michael Karin
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41 min
18. Nuclear receptors at the crossroads of inflammation and atherosclerosis- Prof. Christopher Glass
- Modulation of Effector Responses
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22 min
19. Humoral innate immunity and the acute phase response 1- Prof. Alberto Mantovani
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42 min
20. Humoral innate immunity and the acute phase response 2- Prof. Alberto Mantovani
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54 min
21. Cytokines regulating the innate response- Prof. Anne O’Garra
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39 min
22. Arginase and nitric oxide- Dr. Peter Murray
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38 min
23. Novel lipid mediators in resolution of inflammation- Prof. Charles Serhan
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69 min
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42 min
25. Cationic peptides in innate immunity- Dr. Dawn Bowdish
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27 min
26. Iron metabolism and innate immunity- Prof. Tomas Ganz
- Pathogen-Host Interactions
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46 min
27. Innate recognition of viruses- Prof. Caetano Reis e Sousa
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50 min
28. Type I interferons in innate immunity to viral infections- Prof. Christine Biron
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56 min
29. HIV-1 and immunopathogenesis: innate immunity- Prof. Luis Montaner
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53 min
30. Understanding and combating tuberculosis- Prof. David Russell
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34 min
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51 min
32. Innate immunity and malaria- Prof. Douglas Golenbock
- Health and Disease
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39 min
33. Innate immunity in children- Prof. David Speert
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59 min
34. From bench to bedside: evolution of anti-TNFalpha therapy in rheumatoid arthritis- Prof. Sir Ravinder Maini
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33 min
35. NOD-like receptors in innate immunity and inflammatory disease- Prof. Gabriel Nunez
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38 min
36. Paneth cells in innate immunity and inflammatory bowel disease- Prof. Satish Keshav
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36 min
37. Innate immunity in the brain in health and disease- Prof. V. Hugh Perry
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54 min
38. The fate of monocytes in atherosclerosis- Prof. Gwendolyn Randolph
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49 min
39. Macrophages, a cellular toolbox used by tumors to promote progression and metastasis- Prof. Jeffrey Pollard
- Archived Lectures *These may not cover the latest advances in the field
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73 min
40. Monocyte/macrophages in innate immunity- Prof. Emeritus Siamon Gordon
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32 min
41. Innate immunity in C. elegans- Dr. Jonathan Ewbank
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51 min
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39 min
43. NLR genes: infection, inflammation and vaccines- Prof. Jenny Ting
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63 min
44. Manipulation of innate immune response: lessons from shigella- Prof. Philippe Sansonetti
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35 min
45. Innate immunity of the lung and adaptation to air breathing at birth- Prof. Jeffrey Whitsett
Printable Handouts
Navigable Slide Index
- Introduction
- The global fungal infection problem
- Candida albicans
- Fungi, human disease and immune recognition
- Temporal programme of immune responses
- Questions and aspirations
- Cell wall structure of Candida albicans
- Pathogen-host tool box
- Candida glycosilation mutants used
- Candida mannan importance in various responses
- Candida types affect cytokine production
- Och1 in N-linked mannosylation, cytokine release
- Creation of the "invisible fungus"
- C. albicans phagocytosis is N-mannan-dependent
- Binding to dendritic cells is N-mannan dependent
- Inhibition of binding to dendritic cells (N-mannans)
- Cooperativity in receptor-ligand interactions
- TLR and lectin-like receptor complex synergism
- Fonsecaea pedrosoi
- Fonsecaea pedrosoi- a non-sufficient response
- Artificial PRR co-stimulation cures infection
- Importance of Candida chitin
- Chitin- poly N-acetyl-b-D-glucosamine
- CHS (chitin synthase) genes of C. albicans
- High-chitin C. albicans cells are tolerated in vivo
- Chitin blocks PMNC recognition of C. albicans
- Effects of Caspofungin treatment
- Chitin doesn't block PBMC Salmonella recognition
- Chitin doesn't block recognition via TLR2 or TLR4
- Dectin-1 does not bind chitin directly
- Morphogenesis importance in immune responses
- Hyphae can survive and fight phagocytosis
- Candida morphogenesis and immune recognition
- Hyphae specifically induce Th17 response
- Hyphae specifically induce IL-1beta inflammasome
- Immune tasting of Candida albicans
- A memorable metaphor
- Summary
- Acknowledgments
Topics Covered
- Immune recognition of fungi
- Fungal infections are serious challenges in the clinic
- The innate immune system has a pre-eminent role in containing fungal infection
- Cell wall mutants of Candida can be used to help discover the nature of the recognition mechanisms
- Combining pattern recognition mechanisms can greatly amplify immune response
- Candida mannan in recognition, phagocytosis and activation of immune responses
- Candida chitin importance in cell wall integrity and immune responses
- Candida albicans yeast-hypha morphogenesis: activation and resistance to immune responses
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Gow, N. (2012, July 9). The taste of a fungus: recognition of Candida by the innate immune system [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 1, 2022, from https://hstalks.com/bs/2354/.Publication History
Financial Disclosures
- Prof. Neil Gow has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
The taste of a fungus: recognition of Candida by the innate immune system
Published on July 9, 2012
34 min
Other Talks in the Therapeutic Area: Immunology & Inflammation
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