• Models of Investigation
• 41 min
  1. Antifungal innate immunity in C. elegans

  • Dr. Jonathan Ewbank
• 44 min
  2. The anti-microbial defense of Drosophila: a paradigm for innate immunity

  • Prof. Jules Hoffmann
• 38 min
  3. Phagocytosis in the fruit fly, Drosophila melanogaster

  • Dr. Lynda Stuart
• 62 min
  4. Innate immune sensing and response

  • Prof. Bruce Beutler
• 61 min
  5. Macrophages and systems biology

  • Prof. David Hume
• Cell Types and Recruitment
• 71 min
  6. Leukocyte recruitment in vivo

  • Prof. Paul Kubes
• 51 min
  7. Chemokines and inflammation: a critical assessment of therapeutic targets

  • Dr. David Greaves
• 42 min
  8. Eosinophils

  • Prof. Tim Williams
• 63 min
  9. Dendritic cells: linking innate to different forms of adaptive immunity

  • Prof. Ralph Steinman
• 25 min
  10. Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmunity

  • Prof. Yong-Jun Liu
• 61 min
  11. Innate-like lymphocytes 1

  • Prof. Adrian Hayday
• 41 min
  12. Innate-like lymphocytes 2

  • Prof. Adrian Hayday
• Recognition and Signaling
• 50 min
  13. Colony stimulating factor-1 regulation of macrophages in development and disease

  • Prof. E. Richard Stanley
• 42 min
  14. Fc receptors: linking innate and acquired immunity

  • Prof. Ken G C Smith
• 39 min
  15. Phagocytosis

  • Prof. Joel Swanson
• 44 min
  16. Clearance of apoptotic cells and the control of inflammation

  • Prof. Sir John Savill
• 38 min
  17. Signaling by innate immune receptors

  • Prof. Michael Karin
• 41 min
  18. Nuclear receptors at the crossroads of inflammation and atherosclerosis

  • Prof. Christopher Glass
• Modulation of Effector Responses
• 22 min
  19. Humoral innate immunity and the acute phase response 1

  • Prof. Alberto Mantovani
• 42 min
  20. Humoral innate immunity and the acute phase response 2

  • Prof. Alberto Mantovani
• 54 min
  21. Cytokines regulating the innate response

  • Prof. Anne O’Garra
• 39 min
  22. Arginase and nitric oxide

  • Dr. Peter Murray
• 38 min
  23. Novel lipid mediators in resolution of inflammation

  • Prof. Charles Serhan
• 69 min
  24. Resolvins activate inflammation-resolution programs: a systems approach to resolution

  • Prof. Charles Serhan
• 42 min
  25. Cationic peptides in innate immunity

  • Dr. Dawn Bowdish
• 27 min
  26. Iron metabolism and innate immunity

  • Prof. Tomas Ganz
• Pathogen-Host Interactions
• 46 min
  27. Innate recognition of viruses

  • Prof. Caetano Reis e Sousa
• 50 min
  28. Type I interferons in innate immunity to viral infections

  • Prof. Christine Biron
• 56 min
  29. HIV-1 and immunopathogenesis: innate immunity

  • Prof. Luis Montaner
• 53 min
  30. Understanding and combating tuberculosis

  • Prof. David Russell
• 34 min
  31. The taste of a fungus: recognition of Candida by the innate immune system

  • Prof. Neil Gow
• 51 min
  32. Innate immunity and malaria

  • Prof. Douglas Golenbock
• Health and Disease
• 39 min
  33. Innate immunity in children

  • Prof. David Speert
• 59 min
  34. From bench to bedside: evolution of anti-TNFalpha therapy in rheumatoid arthritis

  • Prof. Sir Ravinder Maini
• 33 min
  35. NOD-like receptors in innate immunity and inflammatory disease

  • Prof. Gabriel Nunez
• 38 min
  36. Paneth cells in innate immunity and inflammatory bowel disease

  • Prof. Satish Keshav
• 36 min
  37. Innate immunity in the brain in health and disease

  • Prof. V. Hugh Perry
• 54 min
  38. The fate of monocytes in atherosclerosis

  • Prof. Gwendolyn Randolph
• 49 min
  39. Macrophages, a cellular toolbox used by tumors to promote progression and metastasis

  • Prof. Jeffrey Pollard
• Archived Lectures *These may not cover the latest advances in the field
• 73 min
  40. Monocyte/macrophages in innate immunity

  • Prof. Siamon Gordon
• 32 min
  41. Innate immunity in C. elegans

  • Dr. Jonathan Ewbank
• 51 min
  42. Antigen processing and presentation: modulation by innate immune signals

  • Prof. Colin Watts
• 39 min
  43. NLR genes: infection, inflammation and vaccines

  • Prof. Jenny Ting
• 63 min
  44. Manipulation of innate immune response: lessons from shigella

  • Prof. Philippe Sansonetti
• 35 min
  45. Innate immunity of the lung and adaptation to air breathing at birth

  • Prof. Jeffrey Whitsett

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. The global fungal infection problem
3. Candida albicans
4. Fungi, human disease and immune recognition
5. Temporal programme of immune responses
6. Questions and aspirations
7. Cell wall structure of Candida albicans
8. Pathogen-host tool box
9. Candida glycosilation mutants used
10. Candida mannan importance in various responses
11. Candida types affect cytokine production
12. Och1 in N-linked mannosylation, cytokine release
13. Creation of the "invisible fungus"
14. C. albicans phagocytosis is N-mannan-dependent
15. Binding to dendritic cells is N-mannan dependent
16. Inhibition of binding to dendritic cells (N-mannans)
17. Cooperativity in receptor-ligand interactions
18. TLR and lectin-like receptor complex synergism
19. Fonsecaea pedrosoi
20. Fonsecaea pedrosoi- a non-sufficient response
21. Artificial PRR co-stimulation cures infection
22. Importance of Candida chitin
23. Chitin- poly N-acetyl-b-D-glucosamine
24. CHS (chitin synthase) genes of C. albicans
25. High-chitin C. albicans cells are tolerated in vivo
26. Chitin blocks PMNC recognition of C. albicans
27. Effects of Caspofungin treatment
28. Chitin doesn't block PBMC Salmonella recognition
29. Chitin doesn't block recognition via TLR2 or TLR4
30. Dectin-1 does not bind chitin directly
31. Morphogenesis importance in immune responses
32. Hyphae can survive and fight phagocytosis
33. Candida morphogenesis and immune recognition
34. Hyphae specifically induce Th17 response
35. Hyphae specifically induce IL-1beta inflammasome
36. Immune tasting of Candida albicans
37. A memorable metaphor
38. Summary
39. Acknowledgments

Topics Covered

• Immune recognition of fungi
• Fungal infections are serious challenges in the clinic
• The innate immune system has a pre-eminent role in containing fungal infection
• Cell wall mutants of Candida can be used to help discover the nature of the recognition mechanisms
• Combining pattern recognition mechanisms can greatly amplify immune response
• Candida mannan in recognition, phagocytosis and activation of immune responses
• Candida chitin importance in cell wall integrity and immune responses
• Candida albicans yeast-hypha morphogenesis: activation and resistance to immune responses

Links

Series:

• Innate Immunity

Categories:

• Biochemistry
• Cell Biology
• Immunology
• Microbiology

Therapeutic Areas:

• Immunology & Inflammation
• Infectious Diseases

Talk Citation

Publication History

• Published on July 9, 2012

Financial Disclosures

• Prof. Neil Gow has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.