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Printable Handouts
Navigable Slide Index
- Introduction
- The human kinome
- TGF-beta - a paradigm for multifunctionality
- TGF-beta in tissue homeostasis
- TGF-beta inhibits cell proliferation
- TGF-beta induces cell cycle arrest
- Two sets of CDK inhibitors in TGF-beta action
- Discovering TGF-beta receptors
- Mechanism of TGF-beta receptor activation
- TGF-beta receptor activation switch
- TGF-beta signaling pathway (1)
- TGF-beta signaling pathway (2)
- Smad protein structure and functions
- Identifying a Smad DNA-binding cofactor
- Smad DNA-binding cofactors
- Context-dependent Smad transcriptional action
- A TGF-beta transcriptional program
- TGF-beta signaling: cytostatic gene responses
- Smad pathway cofactors and regulators
- Smad linker phosphorylation
- HECT ubiquitin ligases recognize linker-pSmads
- Agonist-induced linker phosphorylation
- Linker phosphorylation in mouse embryo
- CDK8/9 mediate linker phosphorylation
- Smurf1, Nedd4L bind to CDK8/9
- Smurf1 and Nedd4L limit length of Smad activation
- Agonist-induced linker phosphorylation activity
- CDK8/9 is driving the Smad cycle
- Transcriptional CDKs
- Inherited human disorders in TGF-beta and BMP
- Loeys-Dietz syndrome
- TGF-beta and cancer
- Somatic mutations impact TGF-beta-Smad
- TGF-beta in cancer
- Cytostatic gene responses lost in cancer
- TGF-beta-Smad pathway
- Summary
Topics Covered
- The TGFb family as a paradigm of multifunctional cytokines
- TGFb controlling embryo development and tissue homeostasis
- TGFb receptor serine/threonine kinases
- SMADs as central TGFb signal transducers and transcriptional mediators
- Logic and organization of TGFb signaling processes
- TGFb pathway regulation and integration in the cell
- TGFb pathway disruption in heritable disorders and cancer
Talk Citation
Massagué, J. (2010, November 30). SMAD phosphorylation and the TGF-beta pathway [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved March 28, 2024, from https://hstalks.com/bs/1892/.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Joan Massagué has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.