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Printable Handouts
Navigable Slide Index
- Introduction
- Mechanisms of antibiotic action
- Resistance is as old as antibiotics
- Antibiotic resistance mechanisms
- Types of resistance
- Defining resistance
- Susceptibility is an interplay of multiple factors
- Antibiotics select resistant bacteria
- Bacteria carry resistance in their DNA
- Resistance is transferred (1)
- Resistance is transferred (2)
- The Red Queen Principle
- Resistance is inevitable
- How quickly does resistance emerge?
- Oxazolidinone timeline
- Mechanism 1: alteration of the target
- The forensics of antibiotic resistance
- Epidemiological investigation of resistance
- Surveillance of resistance
- An example of a trend noticed in surveillance
- Mechanism 2: metabolic by-pass
- Cephalosporin-resistant E. coli
- Why might resistance rates rise?
- Understanding rising prevalence
- Mechanism 3: drug destruction
- Global explosion of CTX-M ESBLs
- Multi-resistance plasmids
- The use of carbapenems
- Mechanism 4: reduced uptake
- Restore porins and reverse carbapenem resistance
- Carbapenemase-mediated resistance in the UK
- The OXA-23 clone 1
- Mechanism 5: up-regulated efflux
- Recap: mechanisms of resistance
- Undefined mechanism of action
- Undefined resistance mechanisms
- Summary
- Acknowledgements
Topics Covered
- Modes of antibiotic action
- Modes of resistance
- Intrinsic / acquired resistance
- Emergence and transfer of resistance
- Monitoring spread
- Modified targets
- Enzymic destruction
- ESBLs
- Plasmidic multi-resistance
- Impermeability / porin loss
- Carbapenemases
- Efflux pumps
Links
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Talk Citation
Woodford, N. (2009, December 31). Antibiotic resistance: a mechanistic overview [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 6, 2024, from https://doi.org/10.69645/CWUB4965.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Neil Woodford has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.