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1. Introduction
2. VDR conformational ensemble
3. Receptor ligand interactions
4. A vitamin D receptor ensemble model
5. VDR-1,25(OH)2D3 (G-pocket) complex
6. A modeling surprise: two pockets found
7. Summary: 1,25(OH)2D3 VDR G- and A-pockets
8. Summary of rapid responses
9. Vitamin D nutrition for good health
10. Where do we obtain vitamin D?
11. How much vitamin D do we need?
12. What is the RDA for vitamin D?
13. How do we obtain our vitamin D RDA? (1)
14. How do we obtain our vitamin D RDA? (2)
15. How do we obtain our vitamin D RDA? (3)
16. Skin cancer is linked to UVB exposure
17. World-wide vitamin D nutrition status
18. What is a measure of vitamin D status?
19. 25(OH)D levels in older women
20. Objective is to increase 25(OH)D in the population
21. Benefits from increasing 25(OH)D levels
22. Vitamin D status and intestinal calcium absorption
23. Nutritional summary
24. New research frontiers
25. Drug development: analogs of 1alpha,25(OH)2D3
26. Drug forms of 1,25(OH)2-vitamin D3 (hormone D)
27. Loss of VDR results in apolecia
28. Analogs of hormone D are effective for psoriasis
29. 1alpha,25(OH)2D3 and the innate immune system
30. Osteoporotic bone
31. Vitamin D in human disease states
32. Summary
33. 1alpha,25(OH)2D3 plus VDR - responses
34. Overall summary
35. Vitamin D3 vs. 1alpha,25(OH)2-vitamin D3
36. Thank you

Topics Covered

• VDR conformational ensemble
• A vitamin D receptor ensemble model
• X-ray crystal structure of the nuclear vitamin D receptor
• VDR G- and A-pocket
• Vitamin D nutrition for good health
• Sources of vitamin D
• How much vitamin D do we need?
• World-wide vitamin D nutrition status
• Vitamin D status and intestinal calcium absorption
• New research frontiers
• Drug development
• Alopecia
• Analogs of hormone D are effective for psoriasis
• hormone-D activates the innate immune system -Vitamin D in human disease states

Links

Series:

• The World of Hormones

Categories:

• Biochemistry
• Metabolism & Nutrition
• Physiology & Anatomy

Therapeutic Areas:

• Cardiovascular & Metabolic

Talk Citation

Norman, A. (2007, December 1). Vitamin D endocrine system: VDR binding, nutrition and drugs development [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 22, 2024, from https://doi.org/10.69645/WVLM7224.
Export Citation (RIS)

Publication History

• Published on December 1, 2007
• Archived on February 25, 2021

Financial Disclosures

• Prof. Anthony Norman has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.