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Menopause & ovarian aging: aging and menopause

Part 1 of 2
Published on September 30, 2025   9 min

Other Talks in the Series: The Female Reproductive System: from Basic Science to Fertility Treatments

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0:00
Welcome, everyone. Today I'm going to talk to you about" Menopause and Ovarian Aging". This is part 1 of 2. My name is Mimi Ghosh. I'm an associate professor at the Department of Epidemiology at the Milken Institute School of Public Health, the George Washington University in Washington, DC.
0:21
The aging population has significantly increased worldwide in the last ten years or so. The number of people aged 65 years or older is projected to more than double, going from 761 million in 2021 to 1.6 billion in 2050. The global population of older women, postmenopausal women is also growing. In 2021, women aged 50 and over accounted for 26% of all women and girls. This was up from 22% just 10 years earlier. Women are living longer. Globally, a woman aged 60 years in 2019 could now expect to live on average another 21 years.
1:06
In the next slide, I have an outline and learning objectives for this talk. As I said, this is part 1. I will talk to you about aging and menopause, focusing on chronological versus biological aging. Then I will talk about systemic aging versus reproductive aging, and then focusing particularly on the aging of the female reproductive tract and ovarian aging. First, aging and menopause chronological and biological aging.
1:35
In the next slide, you see a figure where is showing you the chronological aging of an individual, which is essentially the linear passing of time from birth to old age. This is simply as your age increases every year. This is what we call chronological aging. Now, biological aging is a little bit different. Individuals with the same chronological age may actually have very different biological age. This is because biological aging, as shown in the bottom part of the figure, may be influenced by genes and environment, and lifestyle as well.

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Menopause & ovarian aging: aging and menopause

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