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My name is Eran Gershon,
and I'm a fertility researcher in
the Department of Ruminant Research in the Agricultural Research Organization in Israel.
The topic of my talk is "Stress and Reproduction".
The classic definition of stress is "a state of
real or perceived threat to homeostasis that may challenge an organism's well-being".
The stress response of the body is by the hypothalamus pituitary adrenal HPA axis.
Stress triggers the neurons in the hypothalamus to
secrete corticosteroids releasing hormone, CRH.
That stimulates the release of ACTH from the interior pituitary
ACTH in turn induces the synthesis and secretion of cortisol from the adrenal.
In addition to CRH,
the CRH family of peptides includes Urocortin 1,
Urocortin 2 and Urocortin 3.
CRH in Urocortin activity is mediated by
two transmembrane bound G-protein coupled receptors, CRF-R1 and CRF-R2.
CRH is high affinity to CRF-R1,
while Urocortin 1 has an equal affinity to both CRF-R1 and CRF-R2.
Urocortin 2 and Urocortin 3 bound highly to CRF-R2.
These family of peptides further include CRF binding protein and soluble splice
variant of CRF-R2 that regulate the activity of CRH and Urocortin 1.
How stress affects the body?