Stress and reproduction

Published on April 28, 2021   25 min

Other Talks in the Series: The Female Reproductive System: from Basic Science to Fertility Treatments

My name is Eran Gershon, and I'm a fertility researcher in the Department of Ruminant Research in the Agricultural Research Organization in Israel. The topic of my talk is "Stress and Reproduction".
The classic definition of stress is "a state of real or perceived threat to homeostasis that may challenge an organism's well-being".
The stress response of the body is by the hypothalamus pituitary adrenal HPA axis. Stress triggers the neurons in the hypothalamus to secrete corticosteroids releasing hormone, CRH. That stimulates the release of ACTH from the interior pituitary ACTH in turn induces the synthesis and secretion of cortisol from the adrenal.
In addition to CRH, the CRH family of peptides includes Urocortin 1, Urocortin 2 and Urocortin 3. CRH in Urocortin activity is mediated by two transmembrane bound G-protein coupled receptors, CRF-R1 and CRF-R2. CRH is high affinity to CRF-R1, while Urocortin 1 has an equal affinity to both CRF-R1 and CRF-R2. Urocortin 2 and Urocortin 3 bound highly to CRF-R2. These family of peptides further include CRF binding protein and soluble splice variant of CRF-R2 that regulate the activity of CRH and Urocortin 1. How stress affects the body?