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Printable Handouts
Navigable Slide Index
- Introduction
- Stress
- The hypothalamus -pituitary-adrenal axis (HPA)
- The corticosteroids releasing hormone (CRH) family
- The effect of stress
- The hypothalamus-pituitary-gonads axis (HPG)
- Stress and quality of life (QoL) effects on female fertility
- The impact of stress on GnRH
- The impact of CRH on gonadotropins
- The impact of glucocorticoids on reproductive performances
- The impact of CRH on the reproductive brain circuitry
- The impact of stress on the neuroendocrine reproductive axis - summary
- Ovarian follicle structure and stress
- Interspecies CRH family member expression within the ovary
- Effects of CRH family members and corticosterone on the ovary
- The impact of stress on the ovary
- CRH expression in the uterus
- CRH in the uterus
- CRH in endometriosis
- CRH in adenomyosis
- CRH in embryo implantation
- Placental CRH (pCRH)
- The role of pCRH in embryo development
- The effect of stress on embryo development
- Effect of stress: from embryo to adult life
- Sex differences in response to stress
- CRH binding protein
- The placental clock hypothesis'
- The role of stress mechanism in parturition
- CRH effect on myometrium contraction
- CRH levels in term, pre-term and post-term labors
- High CRH levels, pre-term birth and parturition pathologies
- Genetic adrenal steroids disorders and human fertility
- In summary: the effect of stress on reproduction
- Conclusion
Topics Covered
- The stress response system & the corticosteroids releasing hormone (CRH) family
- The effect of stress on female fertility, ovary, and embryo development
- CRH in uterus and gynecological pathologies
- The different types of CRH and their roles
- The role of stress mechanisms in parturition
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External Links
Talk Citation
Gershon, E. (2021, April 28). Stress and reproduction [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 11, 2024, from https://doi.org/10.69645/MRSK1881.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Eran Gershon has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Other Talks in the Series: The Female Reproductive System: from Basic Science to Fertility Treatments
Transcript
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0:00
My name is Eran Gershon,
and I'm a fertility researcher in
the Department of Ruminant Research in the Agricultural Research Organization in Israel.
The topic of my talk is "Stress and Reproduction".
0:14
The classic definition of stress is "a state of
real or perceived threat to homeostasis that may challenge an organism's well-being".
0:25
The stress response of the body is by the hypothalamus pituitary adrenal HPA axis.
Stress triggers the neurons in the hypothalamus to
secrete corticosteroids releasing hormone, CRH.
That stimulates the release of ACTH from the interior pituitary
ACTH in turn induces the synthesis and secretion of cortisol from the adrenal.
0:53
In addition to CRH,
the CRH family of peptides includes Urocortin 1,
Urocortin 2 and Urocortin 3.
CRH in Urocortin activity is mediated by
two transmembrane bound G-protein coupled receptors, CRF-R1 and CRF-R2.
CRH is high affinity to CRF-R1,
while Urocortin 1 has an equal affinity to both CRF-R1 and CRF-R2.
Urocortin 2 and Urocortin 3 bound highly to CRF-R2.
These family of peptides further include CRF binding protein and soluble splice
variant of CRF-R2 that regulate the activity of CRH and Urocortin 1.
How stress affects the body?