We noted you are experiencing viewing problems
-
Check with your IT department that JWPlatform, JWPlayer and Amazon AWS & CloudFront are not being blocked by your network. The relevant domains are *.jwplatform.com, *.jwpsrv.com, *.jwpcdn.com, jwpltx.com, jwpsrv.a.ssl.fastly.net, *.amazonaws.com and *.cloudfront.net. The relevant ports are 80 and 443.
-
Check the following talk links to see which ones work correctly:
Auto Mode
HTTP Progressive Download Send us your results from the above test links at access@hstalks.com and we will contact you with further advice on troubleshooting your viewing problems. -
No luck yet? More tips for troubleshooting viewing issues
-
Contact HST Support access@hstalks.com
-
Please review our troubleshooting guide for tips and advice on resolving your viewing problems.
-
For additional help, please don't hesitate to contact HST support access@hstalks.com
We hope you have enjoyed this limited-length demo
This is a limited length demo talk; you may
login or
review methods of
obtaining more access.
Printable Handouts
Navigable Slide Index
- Introduction
- Outline: endocrine and paracrine control of ovulation
- Ovulation occurs in the middle of the menstrual cycle
- Feedback control of ovulation
- LH surge turns on key transcription factors
- Which cells can respond to LH?
- Endocrine versus paracrine control of ovulation
- Amphiregulin (AREG)
- The oocyte resumes meiosis
- Cumulus expansion
- Cumulus expansion - COC expansion
- Progesterone - before the LH surge
- Progesterone - after the LH surge
- Progesterone
- Classical progesterone receptors
- Progesterone is needed for primate ovulation
- Angiogenic factors are needed for ovulation
- Angiogenic factors are needed for ovulation - VEGFA and PGF
- PGE2 is synthesized by the ovulatory follicle
- Prostaglandins and human ovulation
- PGE2 is needed for ovulation in primates
- PGE2 is needed for cumulus expansion
- PGE2 is needed for angiogenesis
- PGE2 is needed for ovulatory proteolysis
- PTGS2 and the PGE2 receptor PTGER2 are needed for ovulation
- Summary
- The goal of ovulation: release of a mature oocyte into the oviduct for fertilization
- Main points
- Acknowledgements
Topics Covered
- Endocrine and paracrine control of ovulation
- Feedback control of ovulation
- Endocrine versus paracrine control of ovulation
- Progesterone
- Prostaglandins and human ovulation
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Duffy, D.M. (2021, March 30). Ovulation: endocrine and paracrine control of ovulation [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 3, 2024, from https://doi.org/10.69645/HYKY7779.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Diane Duffy has no commercial/financial relationships to disclose
Ovulation: endocrine and paracrine control of ovulation
Published on March 30, 2021
34 min
Other Talks in the Series: The Female Reproductive System: from Basic Science to Fertility Treatments
Transcript
Please wait while the transcript is being prepared...
0:00
Hello, my name is Diane Duffy.
I'm a Professor and a Vice Chair for Research in
the Department of Physiological Sciences at
Eastern Virginia Medical School in Norfolk, Virginia.
In the first part of my talk,
I described the female reproductive tract and the ovary
and the structural transformation of the ovulatory follicle.
In this second part of my talk,
I will describe the endocrine and paracrine control of ovulation.
0:25
Ovulation involves many interrelated events which must be carefully controlled in
time and especially around the follicle if ovulation is to be successful.
These events are controlled by a primary endocrine signal, luteinizing hormone,
abbreviated LH, and a large number of locally produced hormones called paracrine factors.
0:47
Just to review the basic endocrine control of the menstrual cycle,
antral follicle growth occurs in response to follicle stimulating hormone or FSH.
The fastest growing follicle will become the preovulatory follicle.
This is the follicle that will go on to ovulate.
High levels of estrogen produced by growing follicles
initiates the release of the surge of luteinizing hormone, abbreviated LH.
LH acts at cells of the follicle to stimulate the changes we've already discussed,
which are changes needed for ovulation.
1:20
Endocrine control of ovulation is regulated by
both negative and positive feedback at the hypothalamus and the anterior pituitary.
Generally, steroid hormones, estrogen and progesterone,
have a negative feedback effect at the hypothalamus and anterior pituitary,
meaning that these steroid hormones reduce the amount of FSH and LH released.
In the follicular phase as FSH is stimulating the growth of many follicles,
these growing follicles produce more and more estrogen.
Estrogen feedback reduces the amount of FSH produced to regulate follicle growth.
Declining levels of FSH allow a single,
large responsive follicle to grow large enough to ovulate.
As this growing follicle approaches ovulatory size,
the very high amount of estrogen produced has a positive feedback effect,
resulting in a rapid increase in FSH and LH release.
The increase in serum LH level is substantial and is called the LH surge.
The surge of FSH is also released,
but it is of lower magnitude than the surge of LH.
We believe that the surge of LH provides
the important physiologically meaningful stimulus for ovulation.