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1. Introduction
2. What we cover in this talk
3. Chronic disease in later life
4. Periconception and preimplantation development
5. Epigenetic reprogramming
6. Environment around conception
7. Maternal obesity and overnutrition
8. Developmental origins of health and disease
9. Mouse maternal protein restriction model
10. Emb-LPD and postnatal cardiovascular phenotype
11. Fetal/postnatal growth and adult adiposity
12. Maternal Emb-LPD and postnatal behaviour
13. Adult Emb-LPD offspring exhibit
14. The Dutch hunger winter (5 months) 1944/45
15. Periconceptional human nutrition
16. Early embryo and maternal mutrition (1)
17. Blastocysts ‘sense’ maternal diet by mTORC1
18. In vitro model of Emb-LPD programming
19. Effect of insulin/BCAA culture to blastocyst (1)
20. Effect of insulin/BCAA culture to blastocyst (2)
21. Early embryo and maternal mutrition (2)
22. Poor maternal diet (1)
23. Poor maternal diet & endocytosis in TE
24. Poor maternal diet & endocytosis in PE (1)
25. Poor maternal diet & endocytosis in PE (2)
26. Poor maternal diet & endocytosis in PE (3)
27. Early embryo and maternal mutrition (3)
28. How does the blastocyst regulate fetal growth?
29. Changing the blastocyst's growth trajectory (1)
30. Changing the blastocyst's growth trajectory (2)
31. Poor maternal diet and brain development (1)
32. Poor maternal diet and brain development (2)
33. Poor maternal diet and memory
34. Early embryo and maternal mutrition (4)
35. 5 keypoints
36. Thanks!

Topics Covered

• Early embryo development: the interplay between morphogenesis and the environment
• Developmental Origins of Health and Disease (DOHaD) concept
• How maternal nutrition influences events around conception and changes the programme of development
• Maternal over or under-nutrition can both cause adverse health risk
• Mechanistic understanding of how poor maternal nutrition leads to adult disease involving epigenetic, molecular, cellular, metabolic, and physiologic components

Links

Series:

• The Female Reproductive System: from Basic Science to Fertility Treatments

Categories:

• Diseases, Disorders & Treatments
• Metabolism & Nutrition
• Reproduction & Development

Therapeutic Areas:

• Gynaecology & Obstetrics

Talk Citation

Fleming, T. (2019, April 30). Maternal nutrition, fetal development and long-term health [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved July 21, 2019, from https://hstalks.com/bs/3921/.

Publication History

• Published on April 30, 2019

Financial Disclosures

• Prof. Tom Fleming has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.