My name is Gil Mor, I'm an M.D. Ph.D.
And I'm at the present time,
at the John Malone Jr. Endowed Chair and
Director of the Mott Center for Human
Development at Wayne State University.
There is no conflicts.
When we look at pregnancy complications,
the one that we have in front of us, that
is hemolytic disease of the newborn or
implantation failure, or
recurrent pregnancy loss.
What they have in common
is the reason aspect,
that the maternal immune
system is attacking the fetus.
And contemplating this attack
it comes to ask the question,
"Why did your mother reject
you?" The concept of
why your mother rejects
you comes from this
complexity of the immune
system during pregnancy
where the fetus is considered
an allogenic organ.
And what I mean is, have paternal antigens
that the maternal immune system
recognizes as a foreigner.
And at the same time,
the maternal immune system has to
protect the fetus and
the mother against infections.
So that put us in the condition
that the immune system or
the immunological condition of
pregnancy is a unique condition.
The concept of the recognition
of the fetus as a semi-allograft
was recognized more than 50 years
ago by Sir Peter Medawar in England.
When he claimed the observation
that the fetus,
in genetic terms,
is a semi-allograft which
And what is the meaning
of a semi-allograft?