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Printable Handouts
Navigable Slide Index
- Introduction
- Declaration of possible conflicts of interest
- Factors that can influence body weight
- All of obesity is genetic
- Evidence that all of obesity is genetic (1)
- A study evaluating the intrapair correlation of body weight between twins
- Intrapair correlation of body weight
- Effect of 100 days of overfeeding in 12 pairs of identical twins
- An adoption study of human obesity (1)
- An adoption study of human obesity (2)
- How can obesity be genetic?
- Epigenetics
- Pre-conception
- In Utero
- Post-natal
- Mapped the DNA methylation status
- Evidence that all of obesity is genetic (2)
- Negative feedback system #1
- Negative feedback system #2 (1)
- Negative feedback system #2 (2)
- Osteocytes
- Evidence that all of obesity is genetic (3)
- Central regulation of body weight
- Changes in leptin levels with dieting
- Ghrelin
- Post-breakfast CCK release pre- and post-weight loss
- Results
- Mean change in body weight and leptin levels from baseline to week 62
- Mean fasting and postprandial levels of ghrelin, peptide YY, amylin, and cholecystokinin
- Fasting and postprandial ratings of hunger and desire to eat
- Changes in energy expenditure associated with weight change
- Total (TEE), resting (REE) and non-resting (NREE) energy expenditure
- Leptin levels 6 years after weight loss
- Conclusion
Topics Covered
- Body weight
- Obesity is genetic
- Twin studies
- Adoption studies
- Epigenetic studies
- Central regulation of body weight
- Ghrelin
- Leptin
- Energy expenditure
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Proietto, J. (2025, January 30). Pharmacotherapy for obesity: why it is needed [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved February 5, 2025, from https://doi.org/10.69645/UFHU4202.Export Citation (RIS)
Publication History
Financial Disclosures
- Advisory Board: Novo Nordisk and iNOVA
Pharmacotherapy for obesity: why it is needed
Published on January 30, 2025
28 min
Other Talks in the Series: Obesity: Science, Medicine and Society
Transcript
Please wait while the transcript is being prepared...
0:00
I'm Joe Proietto.
I am a Professor Emeritus at
the University of Melbourne.
I will be talking about
"Pharmacotherapy for Obesity".
There are two parts to
this talk. Two lectures.
Part 1 shows you why it's
necessary to have
pharmacotherapy for the rest
of the life of the patient and
Part 2 will talk about the agents
that we have at the moment.
0:34
Before I start, I'd like to
declare possible
conflicts of interest.
I've given lectures on the
management of obesity for
Novo Nordisk who markets
Saxenda and Wegovy
around the world,
and for iNova here in
Australia who are marketers
of Duromine and Contrave.
1:01
There are many factors that
can influence body weight.
A lot of these are said
to be able to lead to
obesity and these include
the built environment.
In other words, the
lifestyle we have
now in modern times.
Medical conditions
such as, for example,
Cushing's syndrome
or hypothyroidism.
There's quite a bit
of literature about
the microbes that live in
our large bowel
affecting weight.
There's evidence for some
viruses influencing weight.
There are medications
that can change
weight such as steroids
and antipsychotics,
sleep deprivation, stress.
Menopause is known to
cause some weight gain and
some environmental toxins.