Registration for a live webinar on 'Innovative Vaccines and Viral Pathogenesis: Insights from Recent Monkeypox Research' is now open.
See webinar detailsWe noted you are experiencing viewing problems
-
Check with your IT department that JWPlatform, JWPlayer and Amazon AWS & CloudFront are not being blocked by your network. The relevant domains are *.jwplatform.com, *.jwpsrv.com, *.jwpcdn.com, jwpltx.com, jwpsrv.a.ssl.fastly.net, *.amazonaws.com and *.cloudfront.net. The relevant ports are 80 and 443.
-
Check the following talk links to see which ones work correctly:
Auto Mode
HTTP Progressive Download Send us your results from the above test links at access@hstalks.com and we will contact you with further advice on troubleshooting your viewing problems. -
No luck yet? More tips for troubleshooting viewing issues
-
Contact HST Support access@hstalks.com
-
Please review our troubleshooting guide for tips and advice on resolving your viewing problems.
-
For additional help, please don't hesitate to contact HST support access@hstalks.com
We hope you have enjoyed this limited-length demo
This is a limited length demo talk; you may
login or
review methods of
obtaining more access.
Printable Handouts
Navigable Slide Index
- Introduction
- Definition of obesity
- Prevalence of obesity
- Obesity & adverse health consequences
- Obesity as an energy balance disorder
- Adipose tissue as a complex organ
- Adipocytes: multifunctional cells
- Adipose tissue: not an inert fat storage depot
- Adipocytes: dedicated lipid storing cells
- Adipocytes as endocrine cells: Leptin
- Adipocytes as endocrine cells: Adiponectin
- Different shades of adipocytes
- Mammals possess two classes of adipocytes
- Two distinct types of brown adipocytes (classic)
- Two distinct types of brown adipocytes (beige)
- Not all white fat is equal
- White adipocytes are a heterogeneous population
- Waist-hip ratio and myocardial infarction risk
- Lower body fat protects against infarction
- Lower body fat protects against insulin resistance
- Linking fat distribution & metabolic risk
- White adipocytes: a heterogeneous population
- Developmental gene expression signatures
- Genomic loci in or near developmental genes
- Developmental origins of adipose tissue
- White adipose tissue (WAT) development
- WAT maintenance & remodeling
- Adipose precursors
- Embryonic origins of adipocytes
- Adipogenesis occurs in two phases
- Core adipogenic transcriptional cascade
- Factors that control brown & beige adipocytes
- Secreted factors regulate brown, beige adipocyte
- Adipose tissue dysfunction in obesity (1)
- Adipose tissue dysfunction in obesity (2)
- Adipocyte hypoxia
- Adipose tissue fibrosis
- Adipocyte lipid ‘spillover’ & lipotoxicity
- Adipose tissue inflammation
- What initiates inflammation in hypertrophic WAT?
- Altered adipokine profile
- Adipose tissue as a therapeutic target
- Increasing the capacity of WAT to store xs energy
- Lipectomy and lipodystrophy
- Induction of brown & beige fat activity
- Brown & beige fat metabolic benefits
- Brown adipose tissue (BAT)
- Prevalence & activity of BAT in adult humans
- BAT may play a metabolic role in adult humans
- BAT may promote energy expenditure
- BAT may enhance glucose & lipid metabolism
- Conclusions (1)
- Conclusions (2)
Topics Covered
- Adipose tissue biology
- Definition, prevalence and health consequences of obesity
- Adipocytes are multifunctional cells
- Functional classes of adipocytes
- Developmental origins of adipocytes
- Stages and regulation of adipogenesis
- Mechanisms of adipose tissue dysfunction in obesity
- Adipose tissue as a therapeutic target
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Christodoulides, C. (2016, January 31). Adipose tissue biology [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 4, 2024, from https://doi.org/10.69645/NPLM3700.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Constantinos Christodoulides has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Other Talks in the Series: Obesity: Science, Medicine and Society
Transcript
Please wait while the transcript is being prepared...
0:00
Hello, my name is
Costas Christodoulides.
I'm a clinical researcher
from the University of Oxford
and I'm going to talk to you
about adipose tissue biology.
0:11
So obesity is defined as
excessive accumulation
of adipose tissue
that may impair health.
It is commonly classified
by body mass index,
which is the weight
of an individual in kilograms
divided by their height
square in meters.
According to the
World Health Organization
individuals with
a BMI of 25 or above
are classified as overweight,
30 or above, obese,
and less than 18.5, underweight.
The criteria for the definition
of overweight and obesity
are stricter
in Asian populations.
0:48
So the prevalence of obesity
has more than doubled
over the past 30 years
as illustrated in the slide
which shows data
from the United States.
According to the World Health
Organization in 2014,
39 percent of the world's
adult population,
that's more than
1.9 billion individuals,
were overweight and 13 percent
i.e. more than 600 million
subjects were obese.
1:14
Obesity has many adverse
health consequences.
In particular, it is associated
with the development
of insulin resistance
which is linked
to the pathogenesis
of type 2 diabetes
and cardiovascular disease,
including heart
disease and stroke,
which were the leading
global causes of death in 2012.
Obesity is also associated
with osteoarthritis
which is a degenerative disease
of joints
as well as certain forms
of cancer including breast,
colon and endometrial cancer.