0:00
My name is Dr. Thom Barber.
I'm an Associate Professor
and Honorary Consultant
Endocrinologist
based at the University
of Warwick in UK
and UHCW NHS Trust.
So in the second part
of this talk,
I'm going to
specifically talk about
Polycystic Ovary Syndrome,
which is a very common condition
affecting pre-menopausal women
and a condition which is very
closely associated with obesity.
0:24
In this part of the talk,
I will firstly consider
what is PCOS.
I'll talk about
its pathogenesis,
genetic corroboration
with obesity,
links with obstructive
sleep apnea
and then consider specifically
whether having PCOS may
make it harder to lose weight
and also use of
metformin therapy
in women with PCOS.
0:44
So what is
Polycystic Ovary Syndrome?
0:48
Some historical aspects.
In 1921, Archard and Thiers
first made a link between
hirsutism and metabolic
derangements
in their description
of a bearded lady with diabetes.
But it wasn't until 1935
when Stein and Leventhal
first described
the syndrome of PCOS.
But it really wasn't until much
more recently in 1980
when we realized
that Polycystic Ovary Syndrome
is actually
an insulin resistant condition
and a condition
which is associated
with multiple
dysmetabolic features.
And since then, of course,
there has been much research
into the cardiometabolic
associations of PCOS.
