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Printable Handouts
Navigable Slide Index
- Introduction
- Talk outline
- Subgroups of Polycystic Ovary Syndrome (PCOS)
- Historical aspects of PCOS
- Diagnostic criteria of PCOS
- What is polycystic ovary syndrome?
- PCOS versus PCO
- Diagnostic features of PCOS versus associations
- Metabolic dysfunction; ‘Syndrome XX’
- Steroid metabolism
- PCOS pathogenesis
- Genetic predisposition and weight gain
- Effects of secondary hyperinsulinaemia
- Insulin post-receptor pathways
- Metabolic heterogeneity in phenotypic subgroups
- PCOS phenotypic subgroups
- Insulin-resistance in PCOS phenotypic subgroups
- Role of visceral fat
- T1-weighted axial MRI scans & body fat measures
- Fat depot measurements
- Global adiposity in PCOS
- Genetic corroboration with obesity
- FTO gene region: obesity and PCOS
- A allele of FTO rs9939609
- Association of FTO variants with PCOS
- FTO rs9939609 and PCOS in UK samples
- Association of FTO variants with PCOS
- PCOS: Obstructive Sleep Apnoea
- Prevalence of OSA in obese patients with T2D
- Epidemiology and link with insulin resistance
- Does PCOS make it harder to lose weight?
- Possible mechanisms for weight loss difficulty
- Insulin resistance & weight loss
- Postprandial thermogenesis & weight loss
- PCOS: use of metformin
- Metformin: clinical evidence
- Summary
- Thank you
Topics Covered
- What is PCOS?
- Pathogenesis: obesity, insulin resistance and visceral fat
- Genetic corroboration with obesity
- Obstructive sleep apnoea
- Does PCOS make it harder to lose weight?
- Use of metformin
Links
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Talk Citation
Barber, T. (2016, January 31). Obesity and women’s health 2: polycystic ovary syndrome [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved February 23, 2019, from https://hstalks.com/bs/3201/.Publication History
Obesity and women’s health 2: polycystic ovary syndrome
Published on January 31, 2016
45 min
You are viewing a talk that is a part of one of our comprehensive courses. Additional learning material: case studies, projects, workshops and recommended reading; multiple choice questions and suggested exam questions with model answers are available on application. Learn more
Other Talks in the Series: Obesity: Science, Medicine and Society
Transcript
0:00
My name is Dr. Thom Barber.
I'm an Associate Professor
and Honorary Consultant
Endocrinologist
based at the University
of Warwick in UK
and UHCW NHS Trust.
So in the second part
of this talk,
I'm going to
specifically talk about
Polycystic Ovary Syndrome,
which is a very common condition
affecting pre-menopausal women
and a condition which is very
closely associated with obesity.
0:24
In this part of the talk,
I will firstly consider
what is PCOS.
I'll talk about
its pathogenesis,
genetic corroboration
with obesity,
links with obstructive
sleep apnea
and then consider specifically
whether having PCOS may
make it harder to lose weight
and also use of
metformin therapy
in women with PCOS.
0:44
So what is
Polycystic Ovary Syndrome?
0:48
Some historical aspects.
In 1921, Archard and Thiers
first made a link between
hirsutism and metabolic
derangements
in their description
of a bearded lady with diabetes.
But it wasn't until 1935
when Stein and Leventhal
first described
the syndrome of PCOS.
But it really wasn't until much
more recently in 1980
when we realized
that Polycystic Ovary Syndrome
is actually
an insulin resistant condition
and a condition
which is associated
with multiple
dysmetabolic features.
And since then, of course,
there has been much research
into the cardiometabolic
associations of PCOS.