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Hello,
and welcome to the final lecture
in the series Obesity,
Science, Medicine and Society.
I'm Professor Alex Blakemore
and I'm one of the two editors
of this series.
I'm going to give
a few concluding remarks
and talk a little bit
about prospects
for future treatment of obesity.
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Series so far has provided
a wonderful
whistle-stop tour of obesity,
but in each topic
there is still so much to learn,
and lots of questions
come to my mind
when watching the lectures.
I'm sure they do for you too,
so talking about psychology,
I'm interested
in what mechanisms
underlie the relationship
between emotion-handling
and eating behavior?
How does that work?
And what psychological
interventions
would be most
effective long-term?
'Cause it's not too difficult
to get people
to lose weight in the short term
but maintaining that weight loss
is a real challenge.
In the biology, what's exactly
is the relationship
between the gut microbes
and the host body?
How do rare genetic variants
and the SNPs interact?
We know that both involved
in predisposing to obesity,
but how do they work together?
And what are the key
sex differences
in obesity pathogenesis?
Why is it so much
more common in women
than in males?
And what about
adipose tissue dysfunction?
Are there ways that we can
cause our white fat
to become beige or brown fat?
In terms of treating obesity,
what can we do about
interventions?
What kind of public health
approaches can we apply
that would actually work?
Can we provide
non-surgical therapies
by mimicking some of the effects
of bariatric surgery
and after surgery
or after weight loss,
again we come back
to the question,
how can we sustain
weight loss long-term?
Research in all these fields
is ongoing
and is essential to allow us
to develop methods
to personalize treatments
for those with severe obesity.