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Printable Handouts
Navigable Slide Index
- Introduction
- Scientific process
- The conserved Wnt/β-catenin signaling pathway
- The Wnt/β-catenin signaling pathway
- Wnts regulate the body plan
- Three stories about the Wnt pathway
- The awesome power of model organisms to discover pathways regulating development
- Identification of wingless as a recessive gene
- Wnts are secreted proteins & signal at close range
- Wg/Wnt signaling phenotypes
- Wingless discovery in genetic screens in Drosophila
- Wg/Wnts regulate planar cell polarity
- The Wnt/Wingless signaling pathway elucidated by the awesome power of Drosophila genetics
- Mouse
- The discovery of Int-1
- Mouse mammary tumor virus
- Random insertion of a retrovirus can activate a cellular proto-oncogene
- MMTV insertion activates a cellular oncogene
- Int-1 is identical to the Drosophila segment polarity gene wingless
- Wnt meetings - a great place to share new data
- A new nomenclature: the Wnt gene family
- Wnt - a signaling pathway gene that regulates development is also involved in cancer
- Wingless (Wg) is a secreted morphogen
- Mammalian Wnt1 is also a morphogen
- What about Wnt signaling pathways in humans?
- Even simple animals have many Wnt genes
- Mutations in Wnts cause developmental defects
- Mutations in Wnt pathway genes also cause developmental defects
- Wnts are required for adult bones
- What all these Wnts do?
- How do we know about Wnt signaling in human cancers?
- Colorectal cancer
- The intestinal adenoma-carcinoma sequence
- Lessons from hereditary colorectal cancer
- Using the flexible colonoscope
- Intestinal polyps are precursors to cancer
- Familial Adenomatous Polyposis (FAP)
- Identification of the gene
- APC mutations are found in FAP
- Precursor lesions of the colon are readily biopsied
- Colonoscopy allows analysis of early lesions
- Mutations accumulation is required for cancer development
- Truncating mutations of the APC gene
- But isn’t this a lecture on Wnt signaling?
- Immunoprecipitation of APC
- The model
- Where in the colon do APC mutations happen?
- The intestinal crypt - a clonal conveyor belt
- Active Wnt/β-catenin signaling in the intestinal crypt
- Inhibition of Wnt signaling blocks proliferation
- Wnts and Wg
- Break
Topics Covered
- The Wnt/β-catenin signaling pathway
- Wg/Wnt signaling phenotypes
- Wingless discovery in genetic screens in Drosophila
- The discovery of Int-1
- Random insertion of a retrovirus can activate a cellular proto-oncogene
- Wnt: a signaling pathway gene that regulates development is also involved in cancer
- Mutations in Wnts cause developmental defects
- Colorectal cancer
- Familial Adenomatous Polyposis (FAP)
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Talk Citation
Virshup, D. (2024, September 30). The Wnt pathway 1 [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 28, 2024, from https://doi.org/10.69645/QTMC6271.Export Citation (RIS)
Publication History
Financial Disclosures
- There are no commercial/financial matters to disclose.
The Wnt pathway 1
Published on September 30, 2024
42 min