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- Fundamentals of Evolution and Medicine
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1. Evolutionary medicine
- Prof. Randolph Nesse
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2. Evolution and medicine: from the perspective of an evolutionary biologist
- Prof. Stephen C. Stearns
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3. Developmental plasticity, evolution and the origins of disease
- Dr. Mary Jane West-Eberhard
- Evolutionary Genetics
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4. Genetic variation and human disease
- Dr. David Houle
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6. Ecogenetics, evolutionary biology and human disease
- Prof. Gilbert Omenn
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7. Race in genetics and medicine
- Prof. Jeffrey Long
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8. Health disparities in common complex diseases: a role for genetics?
- Dr. Kathleen Barnes
- Infectious Disease
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10. Evolutionary arms races
- Prof. Mark Pagel
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11. Antibiotic resistance and hospital-acquired infection
- Dr. Carl Bergstrom
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12. Evolution of drug resistance
- Dr. Pleuni Pennings
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13. Evolution of virulence: malaria, a case study
- Prof. Andrew Read
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14. Infection and chronic disease
- Prof. Paul Ewald
- Defenses
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15. Fever and related defenses
- Prof. Matthew Kluger
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16. The evolutionary ecology of immunity
- Prof. Paul Schmid-Hempel
- Novel Environmental Factors
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17. What did humans evolve to eat? evolutionary perspectives on human nutritional health
- Prof. William R. Leonard
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19. The paleolithic lifestyle and prevention of chronic disease
- Prof. S. Boyd Eaton
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22. Diseases of civilization: an evolutionary legacy
- Prof. Alan Weder
- Problems Arising From Constraints and Trade-Offs
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23. Aging and evolutionary medicine
- Prof. Linda Partridge
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24. Human aging and menopause
- Prof. Kristen Hawkes
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25. Why we cook with spices: preventative darwinian medicine
- Prof. Paul Sherman
- Sex and Reproduction
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26. Setting the second stage: the evolution of menopause & post-reproductive life
- Prof. Lynnette Sievert
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27. Evolutionary obstetrics
- Prof. Wenda Trevathan
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28. Sex differences in mortality
- Dr. Daniel Kruger
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29. The endocrinology of human life history transitions
- Prof. Peter Ellison
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30. Genetic conflicts in human pregnancy
- Prof. David Haig
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31. Environmental effects on human reproduction
- Prof. Gillian Bentley
- Cancer
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32. A darwinian eye view of cancer
- Prof. Mel Greaves
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33. Viruses and cancer
- Prof. Robin Weiss
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34. Connecting aging and cancer through the lens of evolution
- Prof. James DeGregori
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35. Evolutionary dynamics in cancer control and cure
- Dr. Bob Gatenby
- Specific Body Systems
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36. Hard tissue biology in human health and evolution: enamel biology
- Prof. Timothy Bromage
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37. Hard tissue biology in human health and evolution: bone biology
- Prof. Timothy Bromage
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38. Hard tissue biology in human health and evolution: craniofacial biology
- Prof. Timothy Bromage
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39. Hard tissue biology in human health and evolution: life history and chronobiology
- Prof. Timothy Bromage
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40. Lung biology and lung disease
- Prof. John S. Torday
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41. The evolutionary web of life
- Prof. John S. Torday
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42. Evolutionary considerations and the endothelium
- Dr. William Aird
- Mental Disorders
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43. Evolutionary psychiatry
- Prof. Randolph Nesse
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44. Evolutionary behavioural genetics and mental disorders
- Dr. Matthew Keller
- Questions and Answers
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45. Audience questions about evolution and medicine
- Prof. Randolph Nesse
- Paediatrics
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46. Evolutionary pediatrics
- Dr. Paul Turke
- Microbiome
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47. Evolution, the microbiome, and human health
- Dr. Joe Alcock
- Archived Lectures *These may not cover the latest advances in the field
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48. The hygiene hypothesis
- Prof. Graham Rook
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49. Mapping motivations: evolutionary health promotion
- Dr. Valerie Curtis
- Dr. Robert Aunger
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50. Evolutionary biology of depression
- Prof. Lewis Wolpert
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51. Evolutionary genetic epidemiology
- Prof. Nicholas Schork
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52. Mental disorders in the light of evolutionary biology
- Prof. Randolph Nesse
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53. Evolution: medicine's missing basic science
- Prof. Randolph Nesse
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54. Environmental effects on human reproduction
- Prof. Gillian Bentley
Printable Handouts
Navigable Slide Index
- Introduction
- Purpose of the talk
- Life history theory
- Environmental effects on human reproduction
- Environmental effects on human reproduction: evolutionary approach
- Measuring reproductive function
- How do you measure reproductive function?
- Steroid hormones
- Gonadal function is a more direct measure of reproductive ability
- Protein hormones
- Other ovarian hormones used to assess reproductive function
- Salivary hormones
- Hormonal variation
- Hormonal variation: Tamang and Lese women
- Hormonal variation: male testosterone
- Why such plasticity?
- Effects of weight loss on ovarian function
- Effects of weight loss on ovarian function (Lese)
- Effect of weight loss on ovarian function (Tamang)
- Why such plasticity? Energetic
- Energetics and ovarian function
- Energetics and ovarian function: Polish women
- Ovarian function and reproduction
- Effects of energetic stress
- Low hormones and fertility
- Estradiol levels in conception cycles are higher than in non-conception cycles
- Interpretation
- Ovarian function and energetic stress
- Why such plasticity? Developmental
- Developmental influences on reproduction function
- Developmental theories
- Developmental projects
- Data collected
- Results women aged 18-35
- Women aged 18-35: ovulation and age at menarche
- Results women aged 18-35: adrenarche
- Results women aged 35-59
- Results men aged 17-78
- Results girls aged 5-16
- Adrenarche as a critical window?
- Why such plasticity? Immunological
- Immunological
- Why such plasticity? Genetic
- Genetics
- Interpretation of results
- Health implications across the life course
- Hormones and health
- Health implications (breast cancer risk): hormone levels
- Health implications (breast cancer risk)
- Health implications (breast cancer risk): south Asians and non-Asians
- Types of cancer
- Types of breast cancer
- Types of cancer: global data
- Breast cancer
- Breast cancer in Bangladeshi women
- Hormones and health: conclusion
- Mechanisms to explain plasticity in reproductive function
- Epigenetic mechanisms
- Mechanisms
- Mechanisms: mouse model hormonal levels
- Mechanisms: mouse model follicular development
- Mechanisms: mouse model DNA methylation and mRNA levels
- Adrenarche as a critical window: DNA methylation
- Conclusions
- Thank you
Topics Covered
- Reproductive characteristics vary between individuals and even populations
- Impact of current dietary and activity patterns is only part of the problem
- How early life (childhood) development in different environments can alter the trajectory of reproductive physiology
- Differences in reproductive development have the potential to impact female fertility and health in later life
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Bentley, G. (2023, November 30). Environmental effects on human reproduction [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved January 15, 2025, from https://doi.org/10.69645/ECGJ4881.Export Citation (RIS)
Publication History
Financial Disclosures
- There are no financial matters to disclose.
A selection of talks on Physiology & Anatomy
Transcript
Please wait while the transcript is being prepared...
0:00
Hello, I'm Gillian Bentley
and I'm a Professor
of Biological Anthropology
at Durham University.
I'm going to be talking about
environmental effects
on human reproduction.
0:13
The purpose of my talk is
going to be to discuss
environmental effects
on human reproduction.
I'm going to focus
mainly on females
because that's the gender that
I have worked with for
most of my research.
I'm also going to place the talk
within the framework of
evolutionary medicine,
life history theory
and public health.
I'm going to be discussing
the health implications
versus the adaptive implications
of these environmental effects
on human reproduction.
Also, I'll talk about how
these effects might be
translated quickly
into human physiology.
0:48
What is life history theory?
Basically, this theory argues
that all of our energy
is divided between different
components such as
growth of whatever species
you're talking about
during a childhood
or juvenile period,
maintenance which is how you
just maintain yourself
from day to day.
That does include immune
function as well,
which is a very important
component for every species.
Then reproduction,a
which generally happens
during adulthood.
These allocations among
growth, maintenance,
including immune function,
and reproduction often
involve trade offs.
These can be
particularly prominent
when you are talking
about individuals that
might live in harsh and
stressful environments.
1:33
In talking about
environmental effects
on human reproduction
these include
not only the physical
effects of the environment,
it might be something
like harsh workloads,
nutritional stresses,
but also the social effects
on human reproduction.
Many disciplines are interested
in these environmental effects.
This can include medicine,
clinicians are obviously
very concerned
with what might affect
reproductive function.
Toxicologists might look at
how pollutants for example,
in the environment can
affect reproduction.
Physiologists are interested
in the basic workings of
the reproductive system.
Then social scientists
as well often look
at the components of lifestyle
and the complete
social environment
that can affect
reproduction as well.
Then human biologists that
overlap significantly
with all of these
other disciplines,
are those who are concerned
with human reproduction
and reproductive ecology.
In looking at the
environmental effects