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Printable Handouts
Navigable Slide Index
- Introduction
- Purpose of the talk
- Life history theory
- Environmental effects on human reproduction
- Environmental effects on human reproduction: evolutionary approach
- Measuring reproductive function
- How do you measure reproductive function?
- Steroid hormones
- Gonadal function is a more direct measure of reproductive ability
- Protein hormones
- Other ovarian hormones used to assess reproductive function
- Salivary hormones
- Hormonal variation
- Hormonal variation: Tamang and Lese women
- Hormonal variation: male testosterone
- Why such plasticity?
- Effects of weight loss on ovarian function
- Effects of weight loss on ovarian function (Lese)
- Effect of weight loss on ovarian function (Tamang)
- Why such plasticity? Energetic
- Energetics and ovarian function
- Energetics and ovarian function: Polish women
- Ovarian function and reproduction
- Effects of energetic stress
- Low hormones and fertility
- Estradiol levels in conception cycles are higher than in non-conception cycles
- Interpretation
- Ovarian function and energetic stress
- Why such plasticity? Developmental
- Developmental influences on reproduction function
- Developmental theories
- Developmental projects
- Data collected
- Results women aged 18-35
- Women aged 18-35: ovulation and age at menarche
- Results women aged 18-35: adrenarche
- Results women aged 35-59
- Results men aged 17-78
- Results girls aged 5-16
- Adrenarche as a critical window?
- Why such plasticity? Immunological
- Immunological
- Why such plasticity? Genetic
- Genetics
- Interpretation of results
- Health implications across the life course
- Hormones and health
- Health implications (breast cancer risk): hormone levels
- Health implications (breast cancer risk)
- Health implications (breast cancer risk): south Asians and non-Asians
- Types of cancer
- Types of breast cancer
- Types of cancer: global data
- Breast cancer
- Breast cancer in Bangladeshi women
- Hormones and health: conclusion
- Mechanisms to explain plasticity in reproductive function
- Epigenetic mechanisms
- Mechanisms
- Mechanisms: mouse model hormonal levels
- Mechanisms: mouse model follicular development
- Mechanisms: mouse model DNA methylation and mRNA levels
- Adrenarche as a critical window: DNA methylation
- Conclusions
- Thank you
Topics Covered
- Reproductive characteristics vary between individuals and even populations
- Impact of current dietary and activity patterns is only part of the problem
- How early life (childhood) development in different environments can alter the trajectory of reproductive physiology
- Differences in reproductive development have the potential to impact female fertility and health in later life
Links
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Talk Citation
Bentley, G. (2023, November 30). Environmental effects on human reproduction [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 21, 2024, from https://doi.org/10.69645/ECGJ4881.Export Citation (RIS)
Publication History
Financial Disclosures
- There are no financial matters to disclose.
A selection of talks on Physiology & Anatomy
Transcript
Please wait while the transcript is being prepared...
0:00
Hello, I'm Gillian Bentley
and I'm a Professor
of Biological Anthropology
at Durham University.
I'm going to be talking about
environmental effects
on human reproduction.
0:13
The purpose of my talk is
going to be to discuss
environmental effects
on human reproduction.
I'm going to focus
mainly on females
because that's the gender that
I have worked with for
most of my research.
I'm also going to place the talk
within the framework of
evolutionary medicine,
life history theory
and public health.
I'm going to be discussing
the health implications
versus the adaptive implications
of these environmental effects
on human reproduction.
Also, I'll talk about how
these effects might be
translated quickly
into human physiology.
0:48
What is life history theory?
Basically, this theory argues
that all of our energy
is divided between different
components such as
growth of whatever species
you're talking about
during a childhood
or juvenile period,
maintenance which is how you
just maintain yourself
from day to day.
That does include immune
function as well,
which is a very important
component for every species.
Then reproduction,a
which generally happens
during adulthood.
These allocations among
growth, maintenance,
including immune function,
and reproduction often
involve trade offs.
These can be
particularly prominent
when you are talking
about individuals that
might live in harsh and
stressful environments.
1:33
In talking about
environmental effects
on human reproduction
these include
not only the physical
effects of the environment,
it might be something
like harsh workloads,
nutritional stresses,
but also the social effects
on human reproduction.
Many disciplines are interested
in these environmental effects.
This can include medicine,
clinicians are obviously
very concerned
with what might affect
reproductive function.
Toxicologists might look at
how pollutants for example,
in the environment can
affect reproduction.
Physiologists are interested
in the basic workings of
the reproductive system.
Then social scientists
as well often look
at the components of lifestyle
and the complete
social environment
that can affect
reproduction as well.
Then human biologists that
overlap significantly
with all of these
other disciplines,
are those who are concerned
with human reproduction
and reproductive ecology.
In looking at the
environmental effects