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The mammalian cell cycle: the responsive stage of the cell cycle
Published on March 30, 2023 39 min
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- Prof. Lynn W. Enquist
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Hi. I'm Dr. Stacy Blain from SUNY Downstate Health Science Center. The topic of today's talk is the mammalian cell cycle.
While we have many different cells in our body, we have liver cells that do liver things, and breast cells that do breast things, the one commonality between all of these cells is their ability to regulate their proliferation. These cells have to decide when they make a duplicate copy of themselves or alternatively, whether they remain in a quiet or quiescent state. Some cells in our body are dividing all the time. These would be our skin cells and members of our GI tract. These cells are very short-lived and there needs to be a constant birthing of new cells. Some cells will only divide when they receive the appropriate signals from their extracellular environment, such as our liver cells, or members of our hematopoietic lineages. When our livers gets damaged, those cells can exit that quiet state, make a duplicate copy, restore the liver to the appropriate size, and then re-enter that quiescent state. Some of our cells have the ability to divide but do not divide. These might be members of our cardiac lineages or a neuronal lineages, and they live in that long-term quiescent state for decades. This process of deciding when to divide or not is all important and it help to ensure the integrity of the organs, as well as the size and the functionality. This decision to divide, which is constant, happens every second, every day in all of our cells, is regulated by this balance between proliferative go signals and anti-proliferative stop signals.