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Printable Handouts
Navigable Slide Index
- Introduction
- Viral dynamics in patients on antiretroviral drugs
- A resting CD4+ T cell
- Resting/activated/infected CD4+ T cells
- NFkappaB sites in the HIV LTR
- Establishment/maintenance of latent reservoir
- Frequency of latently infected CD4+ T cells (1)
- Residual viremia and blips - HAART patients (1)
- Frequency of latently infected CD4+ T cells (2)
- Dynamics of the latent pool
- Archival WT/drug resistance in latent reservoir
- HIV evolution
- Persistence of drug resistant variants - example
- Assay for latent HIV in viremic patients
- Archived nevirapine resistance
- Residual viremia and blips - HAART patients (2)
- Analysis of residual viremia in HAART patients
- Results of residual viremia analysis
- Theories regarding the blips in HAART patients
- Analysis of blips with frequent sampling
- No new mutations during blips
- Blips don't represent elevations in viremia
- Additional source of residual viremia
- Detection of predominant plasma sequence (1)
- Detection of predominant plasma sequence (2)
- Why wasn't this phenomenon seen before?
- Predominant plasma clone (PPC)
- Characteristics of the PPC
- Hypothesis on the origin of the PPCs
- PPC and stability of the latent reservoir
- Latent reservoir is not replenished by replication
- Conclusions
Topics Covered
- Viral dynamics in patients on antiretroviral drugs
- CD4+ T-cells
- Response of resting T-cells to AG
- Establishment and maintenance of a latent reservoir
- Dynamics of the latent pool
- HIV evolution
- HAART
- Residual viremia and blips on patients on HAART
- The nature of blips
- Blips do not represent clinically significant elevations in viremia
- Characteristics of the PPC
- The latent reservoir is not replenished by ongoing viral replication in patients on HAART
Links
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Talk Citation
Siliciano, R. (2007, October 1). Viral reservoirs, latency and mechanisms of HIV persistence [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 9, 2024, from https://doi.org/10.69645/YJLS3398.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Robert Siliciano has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.