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Printable Handouts
Navigable Slide Index
- Introduction
- Disclaimers
- Some numbers
- Programmed vs. regulated
- Apoptosis
- Chromosomal translocation in follicular lymphoma
- C. elegans as a cell death model
- Programmed cell death pathway
- The 2002 Nobel Prize
- Caspases
- Types of caspases
- Caspase activation
- A conserved apoptotic pathway
- Apoptosis in brain development
- Mitochondria-mediated apoptosis
- The Bcl-2 family
- Regulation by the Bcl-2 family
- IAP - inhibitor of apoptosis
- Intrinsic apoptosis
- Extrinsic apoptosis
- Life after death
- Evading cell death - a hallmark of cancer
- Apoptosis and cancer
- Apoptosis - mechanisms
- Apoptosis - physiological functions
- Apoptosis/programmed cell death - pathology
- Non-apoptotic, programmed/regulated cell death
- Other cell death modalities
- Various forms of programmed cell death
- General questions
Topics Covered
- Programmed vs. regulated cell death
- Morphological features of apoptosis
- The function and activation of caspases
- Evolutionary conservation of cell death
- The role of mitochondria in cell death
- Apoptosis and its role in cancer development
- Other cell death modalities
Links
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Talk Citation
Jiang, X. (2021, August 29). Programmed cell death [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 11, 2024, from https://doi.org/10.69645/MNZD6050.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Xuejun Jiang has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Other Talks in the Series: The Molecular Basis of Cancer
Transcript
Please wait while the transcript is being prepared...
0:00
My name is Xuejun Jiang.
I am a Member and Professor at the cell biology program of Memorial Sloan Kettering Cancer Center, in New York City.
Today, I will give you a brief overview about a set of cellular processes known as 'programmed cell death'.
My lecture will be given in a way from which you might appreciate, from a historical point of view,
how some of the important concepts in the field were originated, and how they were established experimentally.
We will also briefly discuss the implication of programmed cell death in human diseases, particularly cancer.
0:43
Before I start, I need to make some disclaimers.
First, this lecture is not for experts on cell death research,
but for those who have a general background of biomedical sciences,
and want to gain a rudimentary understanding of cell death.
Second, I'm not able, or qualified, to cover all important topics in the field of cell death,
but my choice of what to include or what is important and
interesting is obviously very subjective and biased.
Lastly, some of the information or theories we discuss today are
still under debate currently, and may even be proven to be wrong in the future,
because our understanding of programmed cell death is rapidly evolving.
But this is the nature of science, ever evolving, and self-correcting.
Now let's get started, by first looking at some numbers.