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- Fundamental aspects
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1. Inflammation and tissue homeostasis
- Prof. Herman Waldmann
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2. Introduction to the immune system
- Prof. Herman Waldmann
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3. Hematopoiesis: the making of an immune system
- Prof. Paul J. Fairchild
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4. Inflammation: purposes, mechanisms and development
- Prof. Pietro Ghezzi
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5. Phagocytosis
- Dr. Eileen Uribe-Querol
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6. Regulated cell death mechanisms and their crosstalk with the immune system 1
- Dr. Luis Alberto Baena-Lopez
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7. Regulated cell death mechanisms and their crosstalk with the immune system 2
- Dr. Luis Alberto Baena-Lopez
- Innate immunity
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11. Cells of the innate immune system
- Prof. Kevin Maloy
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12. Microbial recognition and the immune response
- Dr. Dana Philpott
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13. Toll-like receptor signalling during infection and inflammation
- Prof. Luke O'Neill
- Intercellular mediators
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14. Chemokines
- Dr. James E. Pease
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15. Cytokines
- Prof. Iain McInnes
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16. IL-1 family cytokines as the canonical DAMPs of the immune system
- Prof. Seamus Martin
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17. Glycans at the frontiers of inflammation, autoimmunity and cancer
- Prof. Salomé S. Pinho
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18. Glycoimmunology
- Prof. Paula Videira
- Adaptive immunity B cells
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21. Antigen recognition in the immune system
- Prof. Herman Waldmann
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22. B cell biology
- Prof. Richard Cornall
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23. Antibody structure and function: antibody structure
- Dr. Mike Clark
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24. Antibody structure and function: antibody function
- Dr. Mike Clark
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25. Antibody genes and diversity
- Dr. Mike Clark
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26. In vivo antibody discovery and hybridoma technology
- Prof. Dr. Katja Hanack
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27. Antibody engineering: beginnings to bispecifics and beyond
- Dr. Ian Wilkinson
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29. The immunobiology of Fc receptors
- Prof. Mark Cragg
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30. Immunoreceptors
- Prof. Anton van der Merwe
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31. Affinity, avidity and kinetics in immune recognition
- Prof. Anton van der Merwe
- Adaptive immunity T cells
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32. The thymus and T cell development: a primer
- Prof. Georg Holländer
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33. Lineage decisions in the thymus: T cell lineage commitment
- Prof. Bruno Silva-Santos
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34. Lineage decisions in the thymus: αβ and γδ T cell lineages
- Prof. Bruno Silva-Santos
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35. CD4 T cell subsets
- Dr. Brigitta Stockinger
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36. Cytotoxic T lymphocytes
- Prof. Gillian M. Griffiths
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37. Gamma delta T-cells
- Prof. Bruno Silva-Santos
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38. Tfh and Tfr cells
- Prof. Luis Graca
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39. Tissue resident memory T cells (TRM)
- Dr. Marc Veldhoen
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40. Mathematical modeling in immunology
- Prof. Ruy M. Ribeiro
- The importance of the MHC in immunity
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41. The MHC and MHC molecules 1
- Prof. Jim Kaufman
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42. The MHC and MHC molecules 2
- Prof. Jim Kaufman
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43. Natural killer cells
- Dr. Philippa Kennedy
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44. Human NK cells
- Prof. Lorenzo Moretta
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46. NK cells in viral immunity
- Prof. Lewis Lanier
- Lymphocyte activation
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47. Signal transduction by leukocyte receptors
- Dr. Omer Dushek
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48. Immunological memory 1
- Prof. David Gray
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49. Immunological memory 2
- Prof. David Gray
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50. Studying immune responses “one cell at a time”
- Dr. Mir-Farzin Mashreghi
- Major cellular partners in immunity
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51. The mononuclear phagocyte system - tissue resident macrophages: distribution and functions
- Prof. Emeritus Siamon Gordon
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52. The mononuclear phagocyte system: tissue resident macrophages - activation and regulation
- Prof. Emeritus Siamon Gordon
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53. Dendritic cells: professional antigen presenting cells
- Prof. Paul J. Fairchild
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54. Mucosal immunology
- Prof. Daniel Mucida
- Immunological tolerance and regulation
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55. Self-tolerance
- Prof. Herman Waldmann
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56. Tolerance and autoimmunity
- Prof. Emerita Anne Cooke
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57. The balance between intestinal immune homeostasis and inflammation
- Prof. Dr. Janneke Samsom
- Translational immunology - immune deficiency
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58. Primary immunodeficiency disorders
- Dr. Smita Y. Patel
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59. Changes in innate and adaptive immunity during human ageing 1
- Dr. Roel De Maeyer
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60. Changes in innate and adaptive immunity during human ageing 2
- Dr. Roel De Maeyer
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61. The aging immune system
- Prof. Ana Caetano
- Translational immunology - protection against pathogenic microbes
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62. Immune responses to viruses
- Prof. Paul Klenerman
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63. HIV and the immune system
- Prof. Quentin Sattentau
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64. COVID-19: the anti-viral immune response
- Prof. Danny Altmann
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65. Bacterial immune evasion
- Prof. Christoph Tang
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66. The immunology underlying tuberculosis
- Prof. Thomas R. Hawn
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67. Innate immunity to fungi
- Prof. Gordon D. Brown
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68. Parasite immunity: introduction and Plasmodium
- Dr. Catarina Gadelha
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69. Parasite immunity: Leishmania and Schistosoma
- Dr. Catarina Gadelha
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70. Vaccination
- Dr. Anita Milicic
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71. The history of vaccines 1
- Prof. Emeritus Anthony R. Rees
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72. The history of vaccines 2
- Prof. Emeritus Anthony R. Rees
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73. The history of vaccines 3
- Prof. Emeritus Anthony R. Rees
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74. The science of vaccine adjuvants
- Dr. Derek O'Hagan
- Translational immunology - hypersensitivity, autoimmune disease and their management
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75. Hypersensitivity diseases: type 1 hypersensitivity
- Prof. Herman Waldmann
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76. Innate lymphoid cells in allergy
- Prof. Emeritus Shigeo Koyasu
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77. Hypersensitivity diseases: type II-IV hypersensitivity
- Prof. Sara Marshall
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78. Immune memory underlying lifelong peanut allergy
- Dr. Kelly Bruton
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79. Memory B cells in allergy: B cell activation and response
- Dr. Kelly Bruton
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80. Memory B cells in allergy: ontogeny, phenotype and plasticity
- Dr. Kelly Bruton
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81. B cells at the crossroads of autoimmune diseases
- Dr. Xiang Lin
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82. Interleukin-17: from clone to clinic
- Prof. Leonie Taams
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83. Autoimmunity and type 1 diabetes
- Prof. Emerita Anne Cooke
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84. What is new in type 1 diabetes?
- Prof. Åke Lernmark
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85. Antibodies to control or prevent type 1 diabetes
- Dr. Robert Hilbrands
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86. Monoclonal antibodies in haemato-oncology
- Prof. Mark Cragg
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87. Therapeutic antibodies
- Dr. Geoffrey Hale
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88. Endothelial cells: regulators of autoimmune-neuroinflammation
- Dr. Laure Garnier
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89. Neuroimmunometabolism
- Prof. Ana Domingos
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90. The immunology of multiple sclerosis
- Dr. Joanne Jones
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91. Immunology of the peripheral nervous system: the inflammatory neuropathies
- Dr. Simon Rinaldi
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92. Ocular immunology: an overview of immune mechanisms operating in the eye
- Dr. Eleftherios Agorogiannis
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93. Understanding myasthenia gravis and advances in its management
- Prof. Henry J. Kaminski
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94. The immunology underlying rheumatic diseases
- Dr. Hussein Al-Mossawi
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96. Complement and lupus
- Prof. Marina Botto
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97. Immune mechanisms in liver diseases
- Prof. Paul Klenerman
- Translational immunology - transplantation immunology
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98. Principles of transplantation: overview of the immune response
- Prof. Emerita Kathryn Wood
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99. Factors influencing outcomes in clinical transplantation 1
- Prof. Emerita Kathryn Wood
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100. Factors influencing outcomes in clinical transplantation 2
- Prof. Emerita Kathryn Wood
- Translational immunology - cancer immunology
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101. Cancer immunology
- Prof. Tim Elliott
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102. Cancer immunotherapy
- Prof. Tim Elliott
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103. Myeloid-derived suppressor cells in cancer
- Prof. Dmitry Gabrilovich
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104. IL-2 in the immunotherapy of autoimmunity and cancer
- Prof. Thomas Malek
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105. Latest advances in the development of CAR & TCR T-cell treatments for solid tumours
- Dr. Else Marit Inderberg
Printable Handouts
Navigable Slide Index
- Introduction
- Section 1: Leishmanias & leishmaniasis
- Leishmaniasis (1)
- Leishmaniasis (2)
- Main Leishmania species
- Cutaneous and visceral leishmaniasis
- Status of endemicity of leishmaniasis
- Life cycle
- Section 2: Intracellularity
- Mechanism of host-cell invasion by Leishmania
- Section 3: Infection
- Transmission
- The involvement of innate immune cells - neutrophils
- The involvement of innate immune cells - DCs
- The involvement of innate immune cells - monocytes
- Key cytokines and the TH1 vs. TH2 balance
- IL-10 is an important regulator of immunity in leishmaniasis
- Protective and pathological anti-leishmanial immune response (1)
- Protective and pathological anti-leishmanial immune response (2)
- Protective and pathological anti-leishmanial immune response (3)
- Immunity to leishmaniasis – further reading
- Section 4: Schistosoma & bilharzia
- Schistosomiasis (bilharzia)
- Distribution of schistosomiasis
- Life cycle
- Immune modulation by Schistosoma
- Infiltrating host territory (1)
- Infiltrating host territory (2)
- Camouflaging of the migrating schistosomula
- Survival of adult worms within the vascular system of the host
- How adult worms evade and use the host immune response
- Journey of the schistosome eggs
- Eggs are metabolically active and highly immunogenic
- Intestinal egg excretion
- Immunopathology
- Major cell populations located within and adjacent to a granuloma
- Outcome of disease dependent on response elicited
- Granuloma histology
- Development of immune response
- Summary – development of immune response
- Chronic infection & hyporesponsiveness
- Immunity to schistosomiasis – further reading
- Thank you!
Topics Covered
- Introduction to leishmaniasis
- Life cycle of Leishmania
- Mechanism of host-cell invasion by Leishmania- Transmission of Leishmania
- The involvement of the immune system in leishmaniasis
- Introduction to schistosomiasis (bilharzia)
- Life cycle and distribution of Schistosoma
- Immune response and immune modulation during infection of Schistosoma
- Chronic infection of Schistosoma
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Gadelha, C. (2022, September 29). Parasite immunity: Leishmania and Schistosoma [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved February 5, 2025, from https://doi.org/10.69645/KJXO7759.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Catarina Gadelha has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Parasite immunity: Leishmania and Schistosoma
Published on September 29, 2022
30 min
A selection of talks on Microbiology
Transcript
Please wait while the transcript is being prepared...
0:00
Hello again. My name
is Catarina Gadelha.
I'm a reader in
molecular cell biology
at the University of Nottingham.
My research topic is
host-parasite interactions, with
a particular focus on the
cell surface receptors
and ligands that enable
these interactions.
In this part of the lecture,
we will look at leishmaniasis
and schistosomiasis.
0:32
Leishmaniasis is caused by
several species of
the genus Leishmania,
all transmitted between
mammalian hosts
by female sandflies.
Following a period of
incubation, different species
cause different clinical
manifestations ranging
in severity from self-curing
cutaneous lesions to
life-threatening visceral disease.
The outcome, as usual,
is determined by parasite
and host genetics.
1:03
Cutaneous leishmaniasis,
caused by Leishmania major
or L. tropica is usually
limited to an ulcer
that self heals over
several months,
but can also lead to
scarring and disfigurement.
Mucocutaneous
leishmaniasis is caused
by species of the Viannia group:
Leishmania braziliensis
or L. guyanensis.
It is characterized by
destructive lesions
of the nasal septum,
lips, and palate, and it's
caused by a strong
immunopathological response.
Visceral leishmaniasis,
caused by
Leishmania donovani in Asia
and Africa, or Leishmania
infantum in the Mediterranean,
the Middle East, Central Asia,
and Latin America is the most
severe form of the disease.
Usually fatal unless treated.
Post-kala-azar
dermal leishmaniasis
is a skin manifestation that
occurs in otherwise
healthy people
after treatment of
visceral leishmaniasis.
Table one in this publication
of the journal Lancet,