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- Fundamental aspects
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1. Inflammation and tissue homeostasis
- Prof. Herman Waldmann
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2. Introduction to the immune system
- Prof. Herman Waldmann
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3. Hematopoiesis: the making of an immune system
- Prof. Paul J. Fairchild
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4. Inflammation: purposes, mechanisms and development
- Prof. Pietro Ghezzi
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5. Phagocytosis
- Dr. Eileen Uribe-Querol
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6. Regulated cell death mechanisms and their crosstalk with the immune system 1
- Dr. Luis Alberto Baena-Lopez
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7. Regulated cell death mechanisms and their crosstalk with the immune system 2
- Dr. Luis Alberto Baena-Lopez
- Innate immunity
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11. Cells of the innate immune system
- Prof. Kevin Maloy
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12. Microbial recognition and the immune response
- Dr. Dana Philpott
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13. Toll-like receptor signalling during infection and inflammation
- Prof. Luke O'Neill
- Intercellular mediators
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14. Chemokines
- Dr. James E. Pease
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15. Cytokines
- Prof. Iain McInnes
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16. IL-1 family cytokines as the canonical DAMPs of the immune system
- Prof. Seamus Martin
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17. Glycoimmunology
- Prof. Paula Videira
- Adaptive immunity B cells
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20. Antigen recognition in the immune system
- Prof. Herman Waldmann
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21. B cell biology
- Prof. Richard Cornall
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22. Antibody structure and function: antibody structure
- Dr. Mike Clark
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23. Antibody structure and function: antibody function
- Dr. Mike Clark
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24. Antibody genes and diversity
- Dr. Mike Clark
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25. In vivo antibody discovery and hybridoma technology
- Prof. Dr. Katja Hanack
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26. Antibody engineering: beginnings to bispecifics and beyond
- Dr. Ian Wilkinson
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28. The immunobiology of Fc receptors
- Prof. Mark Cragg
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29. Immunoreceptors
- Prof. Anton van der Merwe
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30. Affinity, avidity and kinetics in immune recognition
- Prof. Anton van der Merwe
- Adaptive immunity T cells
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31. The thymus and T cell development: a primer
- Prof. Georg Holländer
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32. Lineage decisions in the thymus: T cell lineage commitment
- Prof. Bruno Silva-Santos
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33. Lineage decisions in the thymus: αβ and γδ T cell lineages
- Prof. Bruno Silva-Santos
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34. CD4 T cell subsets
- Dr. Brigitta Stockinger
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35. Cytotoxic T lymphocytes
- Prof. Gillian Griffiths
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36. Gamma delta T-cells
- Prof. Bruno Silva-Santos
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37. Tfh and Tfr cells
- Prof. Luis Graca
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38. Tissue resident memory T cells (TRM)
- Dr. Marc Veldhoen
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39. Mathematical modeling in immunology
- Prof. Ruy M. Ribeiro
- The importance of the MHC in immunity
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40. The MHC and MHC molecules 1
- Prof. Jim Kaufman
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41. The MHC and MHC molecules 2
- Prof. Jim Kaufman
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42. Natural killer cells
- Dr. Philippa Kennedy
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44. NK cells in viral immunity
- Prof. Lewis Lanier
- Lymphocyte activation
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45. Signal transduction by leukocyte receptors
- Dr. Omer Dushek
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46. Immunological memory 1
- Prof. David Gray
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47. Immunological memory 2
- Prof. David Gray
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48. Studying immune responses “one cell at a time”
- Dr. Mir-Farzin Mashreghi
- Major cellular partners in immunity
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49. The mononuclear phagocyte system - tissue resident macrophages: distribution and functions
- Prof. Emeritus Siamon Gordon
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50. The mononuclear phagocyte system: tissue resident macrophages - activation and regulation
- Prof. Emeritus Siamon Gordon
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51. Dendritic cells: professional antigen presenting cells
- Prof. Paul J. Fairchild
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52. Mucosal immunology
- Prof. Daniel Mucida
- Immunological tolerance and regulation
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53. Self-tolerance
- Prof. Herman Waldmann
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54. Tolerance and autoimmunity
- Prof. Emerita Anne Cooke
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55. The balance between intestinal immune homeostasis and inflammation
- Prof. Dr. Janneke Samsom
- Translational immunology - immune deficiency
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56. Primary immunodeficiency disorders
- Dr. Smita Y. Patel
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57. Changes in innate and adaptive immunity during human ageing 1
- Dr. Roel De Maeyer
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58. Changes in innate and adaptive immunity during human ageing 2
- Dr. Roel De Maeyer
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59. The aging immune system
- Prof. Ana Caetano
- Translational immunology - protection against pathogenic microbes
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60. Immune responses to viruses
- Prof. Paul Klenerman
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61. HIV and the immune system
- Prof. Quentin Sattentau
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62. COVID-19: the anti-viral immune response
- Prof. Danny Altmann
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63. Bacterial immune evasion
- Prof. Christoph Tang
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64. The immunology underlying tuberculosis
- Prof. Thomas R. Hawn
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65. Innate immunity to fungi
- Prof. Gordon D. Brown
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66. Parasite immunity: introduction and Plasmodium
- Dr. Catarina Gadelha
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67. Parasite immunity: Leishmania and Schistosoma
- Dr. Catarina Gadelha
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68. Vaccination
- Dr. Anita Milicic
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69. The history of vaccines 1
- Prof. Emeritus Anthony R. Rees
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70. The history of vaccines 2
- Prof. Emeritus Anthony R. Rees
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71. The history of vaccines 3
- Prof. Emeritus Anthony R. Rees
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72. The science of vaccine adjuvants
- Dr. Derek O'Hagan
- Translational immunology - hypersensitivity, autoimmune disease and their management
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73. Hypersensitivity diseases: type 1 hypersensitivity
- Prof. Herman Waldmann
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74. Innate lymphoid cells in allergy
- Prof. Emeritus Shigeo Koyasu
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75. Hypersensitivity diseases: type II-IV hypersensitivity
- Prof. Sara Marshall
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76. B cells at the crossroads of autoimmune diseases
- Dr. Xiang Lin
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77. Interleukin-17: from clone to clinic
- Prof. Leonie Taams
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78. Autoimmunity and type 1 diabetes
- Prof. Emerita Anne Cooke
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79. What is new in type 1 diabetes?
- Prof. Åke Lernmark
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80. Antibodies to control or prevent type 1 diabetes
- Dr. Robert Hilbrands
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81. Monoclonal antibodies in haemato-oncology
- Prof. Mark Cragg
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82. Therapeutic antibodies
- Dr. Geoffrey Hale
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83. Neuroimmunometabolism
- Prof. Ana Domingos
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84. The immunology of multiple sclerosis
- Dr. Joanne Jones
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85. Understanding myasthenia gravis and advances in its management
- Prof. Henry J. Kaminski
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86. The immunology underlying rheumatic diseases
- Dr. Hussein Al-Mossawi
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88. Complement and lupus
- Prof. Marina Botto
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89. Immune mechanisms in liver diseases
- Prof. Paul Klenerman
- Translational immunology - transplantation immunology
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90. Principles of transplantation: overview of the immune response
- Prof. Emerita Kathryn Wood
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91. Factors influencing outcomes in clinical transplantation 1
- Prof. Emerita Kathryn Wood
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92. Factors influencing outcomes in clinical transplantation 2
- Prof. Emerita Kathryn Wood
- Translational immunology - cancer immunology
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93. Cancer immunology
- Prof. Tim Elliott
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94. Cancer immunotherapy
- Prof. Tim Elliott
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95. Myeloid-derived suppressor cells in cancer
- Prof. Dmitry Gabrilovich
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96. IL-2 in the immunotherapy of autoimmunity and cancer
- Prof. Thomas Malek
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97. Latest advances in the development of CAR & TCR T-cell treatments for solid tumours
- Dr. Else Marit Inderberg
Printable Handouts
Navigable Slide Index
- Introduction
- Rheumatoid arthritis (RA): a revolution in outcomes
- RA pathology
- Synovium - macroscopic
- Cells in joints: healthy and inflamed
- RA management (1990 - 2020)
- Radiological damage - determinant of disability
- Survival according to first year HAQ*
- RA: increased morbidity and mortality
- Summary: joint damage in RA
- Leiden early arthritis clinic
- TICORA* at 18 months
- Early RA in 2020
- TNF inhibitors
- TNF blockade
- Anti-TNF in established RA (I)
- ASPIRE study: structural damage
- TNF blockade in RA
- Originator anti-TNF biologics
- Anti-TNF and serious infections (SIs)
- TNF blockade and tuberculosis
- Intracellular infections
- Anti-TNF and malignancy meta-analysis
- Anti-TNF in established RA (II)
- Non-TNF inhibitors
- B cells in RA pathophysiology
- Protein CD20
- Rituximab - a chimeric murine antibody
- Serious infusions related reactions (IRRs)
- Infection rate
- Targeting T-cells: co-stimulation blockade
- CTLA4-Ig - immunoglobulin fusion protein
- IL-6 receptor blockade
- Systemic effects of IL-6
- Tocilizumab inhibits IL-6R signalling
- Tocilizumab: SAEs in clinical trials
- Summary: biological therapies for RA
- Biologic responsiveness in RA: precision medicine
- Biosimilars
- What is in a vial of therapeutic antibody?
- Biosimilars - the challenge
- Drug development pathways
- Regulatory requirements
- Advantages of biosimilars
- Disadvantages of biosimilars
- Immunogenicity
- Anti-drug antibodies (ADAs)
- Conclusions
Topics Covered
- Pathology of rheumatoid arthritis
- Management of rheumatoid arthritis
- Biological therapies for rheumatoid arthritis
- TNF inhibitors, non-TNF inhibitors, and biosimilars
- Clinical trials for rheumatoid arthritis
Links
Series:
- The Immune System - Key Concepts and Questions
- Monoclonal Antibodies as Therapeutic Agents
- Periodic Reports: Advances in Clinical Interventions and Research Platforms
Categories:
Therapeutic Areas:
Talk Citation
Isaacs, J. (2020, May 31). Modern management of rheumatoid arthritis - with a focus on biologic therapies [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 26, 2024, from https://hstalks.com/bs/4295/.Export Citation (RIS)
Publication History
Financial Disclosures
- There are no commercial/financial matters to disclose.
A selection of talks on Immunology
Transcript
Please wait while the transcript is being prepared...
0:00
Hello, my name is John Isaacs,
I'm Professor of Clinical Rheumatology
at Newcastle University, and
my presentation is on modern therapy for
rheumatoid arthritis.
0:13
There's been a revolution in rheumatoid
arthritis outcomes over the last 30 years,
in the image on the left is a typical
rheumatoid arthritis patient from
the 1990s when I started seeing rheumatoid
arthritis patients, and on the right is
how I would expect my patients to look
today, you can see the big difference.
0:32
To understand what's going on,
I wanted to talk a little bit about
rheumatoid arthritis pathology.
In this cartoon, the left hand side shows
a normal joint, and the right hand side
shows the equivalent joint in
a person with rheumatoid arthritis.
You can see there are two bones there and
they're joined by the brown joint capsule,
the yellow is the articular cartilage
(the gristle), and the really important
thing we're going to talk about is
the synovium, or the pink line.
In health you can see this
membrane is quite thin,
in rheumatoid it becomes a very bulky
proliferating tissue, and you can
see that proliferating tissue is actually
invading into the cartilage and bone.
In fact when we do imaging such as X-rays,
MRI-scans or CT-scans, we look for
erosions which are holes in the bone,
as you can see indicated by the arrow,
this is effectively an image
of that invading synovium.
1:30
The next slide shows what you would
see if you looked into a joint.
On the left hand side (using an
arthroscope), in a normal joint you can't
see the synovial membrane, it's so
thin that it's transparent and
you're looking at the blood vessels
underlying the synovial membrane.
On the right,
you can see an inflamed joint, and
what you can see in this joint is that
because of the proliferating bulky
synovium it's now forming polyploid
processes protruding into the joint.
Below that you can see
a more chronic picture,
there's lots of fibrin and
a very messy interior to that joint.
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