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- General Virology
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1. Principles of virology
- Prof. Vincent Racaniello
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2. The type I interferon system and viruses
- Dr. Adolfo Garcia-Sastre
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3. Immune responses to viruses
- Prof. Paul Klenerman
- Emerging Pathogens
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4. Emerging or newly discovered viral causes of acute lower respiratory tract infections worldwide
- Dr. Marietjie Venter
- Mrs. Orienka Hellferscee
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5. Emerging respiratory viruses - discoveries between 2001 and 2005
- Prof. Ron Fouchier
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6. Usage of vaccines and therapeutics in public health emergencies 1
- Prof. Gary Kobinger
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7. Usage of vaccines and therapeutics in public health emergencies 2
- Prof. Gary Kobinger
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8. Influenza virus pandemics: past and future
- Prof. Peter Palese
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9. SARS-CoV and other emerging coronaviruses
- Prof. Ralph Baric
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10. Dengue, Zika and Chickungunya viruses
- Prof. Ana Fernandez-Sesma
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11. Paramyxoviruses: biology & pathogenesis
- Prof. Benhur Lee
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12. Antiviral drugs (non-HIV)
- Prof. Megan Shaw
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13. Biodefense challenges
- Dr. David Franz
- Important Pathogens and their Diseases
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14. Natural history and pathogenesis of herpes virus infections
- Prof. Richard Whitley
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15. Cytomegalovirus biology
- Prof. Domenico Tortorella
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16. Hepatitis C virus: discovery, cure and protection
- Dr. Matthew Evans
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17. Fundamentals of HIV biology
- Prof. Viviana Simon
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18. Measles
- Prof. Diane E. Griffin
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19. Monkeypox virus, vaccines, and therapeutics
- Prof. Rachel Roper
- New Frontiers
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22. Viruses as anticancer weapons
- Prof. Roberto Cattaneo
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23. Novel approaches to diagnosis of viral infections
- Prof. W. Ian Lipkin
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24. The Global Virus Network: collaboration to address pandemic and regional threats
- Prof. Sten H. Vermund
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25. Elite controllers of HIV: from discovery to future therapies
- Prof. Bruce Walker
- Archived Lectures *These may not cover the latest advances in the field
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26. Principles of virology I
- Prof. Richard Condit
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27. Principles of virology II
- Prof. Richard Condit
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28. Complex DNA viruses: herpes virus
- Dr. John Blaho
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29. Adeno-associated viruses (AAV)
- Prof. Kenneth Berns
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30. Poxviruses: smallpox (variola), vaccinia and monkeypox
- Prof. Paula Traktman
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31. Can HPV testing be the sole primary cervical screening modality?
- Prof. Jack Cuzick
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32. From viruses to oncolytics
- Prof. Roberto Cattaneo
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33. Non HIV antivirals
- Prof. Mary Klotman
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34. Gastroenteritis viruses
- Prof. Mary Estes
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35. Biodefense challenges
- Dr. Connie Schmaljohn
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37. The past, present and future of vaccination
- Prof. Stanley Plotkin
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38. Filoviruses
- Dr. Christopher Basler
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39. Bunyaviruses
- Prof. Richard Elliott
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40. The immunobiology of HIV
- Prof. Norman Letvin
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41. Hepatitis C and HCV
- Prof. Stanley Lemon
Printable Handouts
Navigable Slide Index
- Introduction
- Talk outline
- Viruses as pathogens and tools
- Viruses as vaccines
- Viruses as vaccines - results
- The frontier: from viruses to oncolytics
- Oncolytic virotherapy - definition
- The promise of oncolytic virotherapy
- Targeting viruses to tumors: layers of specificity
- DNA viruses in cancer clinical trials
- RNA viruses in cancer clinical trials
- Measles as an oncolytic virus
- Regression of lymphoma after measles infection
- Pre-clinical trials with oncolytic measles viruses
- Biology of measles virus
- Measles and non-segmented negative RNA viruses
- Measles virus particles
- Expression of reproter genes in measles virus
- Measles virus - genome and particle activation
- Matrix metalloproteinases (MMP)
- In situ activation of viruses by MMPs
- MV fusion protein activation and inactivation
- Conferring MMP-2 specific activation
- Recovery of MMP-activated MV
- MV-MMP-A: fusion of MMP-secreting cells
- MV-MMP-A1: safety and efficacy
- Summary - first layer of targeting
- Tropism retargeting - layer 2, cell entry
- The strategy: modification of attachment protein H
- Retargeting cell entry (1)
- Measles virus receptor SLAM/CD46 based tests
- Mutants supporting SLAM/CD46 dependent fusion
- SLAM/CD46-dependent fusion important residues
- Entry through targeted receptor
- Retargeting cell entry (2)
- Retargeting tropism: layer 3 and layer 4
- Retargeting tropism: spread (1)
- Oncolytic MV have a mutated Zn-binding domain
- Properties of the mutated V protein
- Conservative modification of V protein
- Retargeting tropism: spread (2)
- Interaction of V protein with mda5 and STAT2
- Interaction of V and P with STAT1
- Recombinant measles virus with desired mutations
- Retargeting tropism: spread (3)
- Topical clinical trials
- Oncolytic viruses as cancer therapeutics
- Head and neck carcinoma: approved regimen
- Ongoing trials: prostate cancer
- Ongoing trials: glioma
- Ongoing trials: advanced liver tumors
- Ongoing trials: superficial tumors
- Ovarian carcinoma, multiple myeloma
- Summary of clinical trials
- Improving efficacy of oncolytic virotherapy activity
- Choosing the ideal oncolytic virus
- Acknowledgements
Topics Covered
- Viruses: molecular biology and reverse genetics
- Tropism determinants: entry and post-entry levels
- Tropism targeting: protease activation, receptor attachment, transcription/replication, spread
- Cancer clinical trials: recombinant adeno-, herpes, vaccinia and measles viruses
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Cattaneo, R. (2007, October 1). From viruses to oncolytics [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 6, 2024, from https://doi.org/10.69645/PXFF1674.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Roberto Cattaneo has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.