The world of lupus

Published on November 30, 2017   21 min

Other Talks in the Therapeutic Area: Immunology & Inflammation

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My name is Graham Hughes. I'm the head of the London Lupus Centre at London Bridge Hospital shown here in front of the Shard which is more well-known, I suppose. I'm going to give a talk which encompasses
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a lot about lupus but is only specifics about certain aspects, and the first is something about the history as I've seen it anyway of lupus.
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Like so many diseases, the disease goes back in its description to William Osler, and in 1895 he described a disease of unknown aetiology, skin lesions, arthritis, GI crises, endocarditis, pericarditis, but very important was recurrence is a special feature of the disease. So, many people say that these probably are of the earliest descriptions of the full syndrome of lupus a 120 years ago. This is an interesting one for me because this was a first report to our knowledge of
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the use of anti-malarials in lupus and this was by a Dr. Payne who was a skin physician at my hospital St. Thomas's, and he produced a paper in 1894 showing that quinine might be of help in cutaneous lupus and nothing basically is new. My own training was in Whitechapel at