The world of lupus

Published on November 30, 2017   21 min

Other Talks in the Therapeutic Area: Immunology & Inflammation

My name is Graham Hughes. I'm the head of the London Lupus Centre at London Bridge Hospital shown here in front of the Shard which is more well-known, I suppose.
I'm going to give a talk which encompasses a lot about lupus but is only specifics about certain aspects, and the first is something about the history as I've seen it anyway of lupus.
Like so many diseases, the disease goes back in its description to William Osler, and in 1895 he described a disease of unknown aetiology, skin lesions, arthritis, GI crises, endocarditis, pericarditis, but very important was recurrence is a special feature of the disease. So, many people say that these probably are of the earliest descriptions of the full syndrome of lupus a 120 years ago.
This is an interesting one for me because this was a first report to our knowledge of the use of anti-malarials in lupus and this was by a Dr. Payne who was a skin physician at my hospital St. Thomas's, and he produced a paper in 1894 showing that quinine might be of help in cutaneous lupus and nothing basically is new.
My own training was in Whitechapel at the London Hospital and where we all enjoyed our work and learned quite a lot.
It was famous for a lot of things in London, but they also had a thing called the lupus lamp, which was the fashion at the time, and this was a light which helped skin rashes but it turned out it was more used for tuberculosis than for lupus, and I think that the idea that it was our type of lupus that it treated is failing, but at least it put London Hospital, somewhat on the map at that time. In 1969, I was fortunate enough to win a scholarship to go from our hospital to America,