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Printable Handouts
Navigable Slide Index
- Introduction
- Binge eating disorder
- Mx BED and emotional eating
- μ-Opioid receptor antagonist in BED
- Endocannabinoids and appetite
- Nutritional influences
- Nutritional state and high-low energy foods
- OFC activation - appeal bias & hunger change
- Hormonal influences
- Circulating hormones control eating behaviour
- Ghrelin and DA release in nucleus accumbens
- Ghrelin - fasting effect on food reward?
- Ghrelin increases brain hedonic responses to food
- Ghrelin & Hippocampus activation to food
- Ghrelin & auditory, motor/visual cortex activation
- Summary – hormonal influences
- GLP-1 agonist/antagonist research
- PYY&GLP-1: food intake & reward activation
- Surgical influences
- Bariatric surgical procedures
- Long-term weight loss after bariatric surgery
- Dietary habits after bariatric surgery
- Progressive ratio task for appetitive reward
- Anticipatory food reward in bariatric patients
- Similarly reduced hunger after bariatric surgeries
- High-calorie food appeal after gastric bypass
- Brain activation to high-calorie foods after bypass
- Differences in OFC and Amygdala activation
- Ice-cream palatability & fat intake after bypass
- Anticipatory-consummatory reward after surgery
- Roux-en-Y gastric bypass is a complex procedure
- Bariatric surgery:satiety gut hormones & bile acids
- Dumping symptoms - gastric bypass vs banding
- Octreotide & anorexigenic gut hormones
- Octreotide & post-prandial anticipatory food reward
- Octreotide & suppression of PYY and GLP-1
- Core behavioural components in obesity
- MID task
- MID task and addiction/obesity
- Impulsivity and obesity
- Emotional eating
- GLP-1 & ghrelin reduce drug / alcohol reward
- Conclusions
Topics Covered
- Binge eating disorder
- Nutritional state influences
- Gut hormone influences
- Bariatric surgery influences
Links
Series:
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Therapeutic Areas:
Talk Citation
Goldstone, T. (2016, January 31). Obesity and the hedonic response 2 [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 26, 2024, from https://doi.org/10.69645/BAMT1703.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Tony Goldstone, Other: NovoNordisk (Data Monitoring Committee for trials of Liraglutide in Prader-Willi syndrome and adolescent obesity)
Obesity and the hedonic response 2
Published on January 31, 2016
35 min
Other Talks in the Series: Obesity: Science, Medicine and Society
Transcript
Please wait while the transcript is being prepared...
0:00
Welcome back. This is Part 2 of our talk around the hedonic aspects of eating.
0:08
Now, there may be particular types of people for whom the addictive behaviours,
and eating behaviours may be particularly more
homogeneous and maybe some of the reasons why our differences in obesity
are so marked between the different studies,
because we are with a very heterogeneous cause.
Binge eating disorder may be regarded as
perhaps a more homogeneous cause of obesity and a more homogeneous eating behaviour.
In bariatric clinics, it accounts for about a quarter to maybe a third of patients.
It's characterised by situations in which people will eat a large amount of food,
maybe the amount they would normally eat in a whole day in
a relatively short period of time with a subjective feeling of loss of control,
with no associated purging such as vomiting as is seen in bulimia nervosa or use of
laxatives or excessive exercise.
There are also certain frequencies which need to be done in order to meet the diagnosis.
The episodes are associated with eating very rapidly,
and people feeling quite uncomfortable,
even eating when they're not hungry,
often eating alone or in secret and feelings of disgust and guilt afterwards.
It's exacerbated by emotional stress and also by skipping meals,
suggesting that the homeostatic changes may also impact on that.
There have been some brain imaging studies comparing
people with binge eating and non-binge eating.
Binge-eating may be associated with normal weight.
But in these studies, they compare people
who are overweight with or without binge eating.
As you can see in the picture,
people who had binge eating had greater activation within the brain,
including within the orbitofrontal cortex.
Binge-eating is associated with worse outcomes
in lifestyle interventions such as the Look AHEAD study recently from the States.
Bariatric surgery is not a cure for these behaviours,
and psychological support is needed.
If people do persist to having some of these abnormal eating behaviours after surgery,
they necessarily don't do as well in terms of losing weight.