0:00
Hello, my name is
Dr. Tony Goldstone.
I'm a Consultant Endocrinologist
and Clinician Scientist
at the Imperial College London.
And I'm gonna talk
today about obesity
and the hedonic response.
0:14
We all know that we are
facing an obesity epidemic.
And what I'm trying to
discuss in my talk today
is how the environment
that we live in,
which is
an obesogenic environment,
is interacting
with our basic biology
through
a combination of genetics,
although I'm not particularly
gonna discuss genetics today,
'cause that's being covered
in some of your other talks.
But particularly
with our psychology
and our physiology,
to maintain and promote
obesity through not only
how hungry we are,
as far as
our appetite is concerned,
but also the hedonic
and rewarding aspects of food
and how these interact
to make it difficult for us
to lose weight.
0:54
So the topics I'm gonna
discuss in my talk today,
I'm gonna firstly discuss
a little bit about
the neurobiology of
food reward and food hedonics
and then give some examples,
particularly using
functional braid imaging
as our tool
to investigate how food reward
and hedonics
maybe influenced by obesity,
also by eating behavior itself,
which may be
a better thing to investigate
than obesity per se,
to delve a little bit
into some of
the neurotransmitter systems
that may be involved
in this, particularly,
the role for
the dopaminergic system
and the endogenous opioids.
Some specific examples
of particular eating behaviors
that may particularly
involve the food reward system
such as binge eating disorder,
and the concept
of food addiction.
And then,
in the latter half of the talk,
some examples
where various systems
interact with this,
particularly
the role of nutritional state,
gut hormones,
and the specific example
of the role of bariatric surgery
as a way
of modifying food reward,
and really trying to emphasize
that the distinction between
the homeostatic mechanisms
that control our eating behavior
tightly integrated
with the hedonic reward
and cognitive aspects of eating.
So this slide gives
a summary of the sort of things
