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Navigable Slide Index
- Introduction
- Talk outline
- The immune response in tuberculosis
- Protective factors in the immune response to Mtb
- Protection or pathogenesis: T cells in TB
- Protection or pathogenesis: cytokines in TB
- Protection or pathogenesis: resistant/susceptible
- Mtb: resistant & susceptible mouse models
- Factors that regulate host responses in TB
- Potential regulatory roles for IL-10 in Mtb
- Suggestive roles for IL-10 in human TB
- IL-10 in mouse models of TB: conflicting reports
- Enhanced IL-10 production in "susceptible" mice
- Experimental overview
- IL-10 is produced in the lung during Mtb infection
- Mtb in the absence of IL-10 in BALB/c mice
- Mtb H37Rv infection in the absence of IL-10
- Enhanced protection to Mtb: IL-10 & Th1 response
- IL-10 in immune regulation during Mtb infection
- The human immune response in tuberculosis
- Tuberculosis: a major human threat (epidemiology)
- Difficulties in dealing with tuberculosis
- Tuberculosis: a major human threat (Dx and Tx)
- 2 billion people have "latent tuberculosis"
- "Latent TB" into active TB: no test
- Transcriptional signatures (latent vs. active TB)
- Study design
- Blood reflects cell migration throughout body
- London the tuberculosis capital of Europe
- Active vs. latent TB: distinct transcriptional profile
- 393 transcripts derived from statistical filtering
- Blood transcriptional signature validation (London)
- TB is a global disease
- Outliers in Latent and Active Tuberculosis
- Transcriptional signature in active TB (London)
- Active TB signature correlates with radiography
- Active TB signature is diminished on treatment
- TB signatures for treatment monitoring
- Transcriptional modules
- Finding common clusters across diseases
- Classical versus modular approach
- Modular signature of active TB: UK vs. SA (1)
- TB signature distinct from other diseases
- Modular signature of active TB: UK vs. SA (2)
- IFN-inducible genes present in active TB patients
- Bacterial pathogens can induce IFN production
- Type 1 IFN can down-regulate IFN-gamma receptor
- Mtb infection and type 1 IFN
- Human disease and experimental models
- Acknowledgements
- Collaborators
- The MRC National Institute for Medical Research
- The Francis Crick institute
Topics Covered
- Tuberculosis (TB) as a major human threat
- T cells & cytokines in TB
- Difficulties in dealing with TB
- Resistant & susceptible TB mouse models
- Potential regulatory roles for IL-10 and factors that regulate host responses in TB
- "Latent TB" into active TB and distinct transcriptional signatures
- Finding common transcriptional clusters across diseases
- TB and type 1 IFN: Bacterial pathogen induction of IFN production and IFN-inducible genes present in active TB patients
Links
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Talk Citation
O’Garra, A. (2012, December 27). Regulation of the immune response to pathogens 2 [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 2, 2024, from https://doi.org/10.69645/VVCD8426.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Anne O’Garra has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Regulation of the immune response to pathogens 2
Published on December 27, 2012
33 min