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Printable Handouts
Navigable Slide Index
- Introduction
- Talk outline
- Adaptive immune responses
- Macrophage engulfing bacteria
- Dendritic cells in association with T cells
- The immune response to pathogens
- Th1 and Th2 cells in immune regulation
- Th1 and Th2 subsets originally doubted
- Testing Th1 and Th2 differentiation
- Main cytokines driving Th1 or Th2 differentiation
- Cytokines regulate Th1 & Th2 cells development
- How Th1 & Th2 cells develop from a naive T cell
- Cells involved in a Th2 response
- Cytokine regulation of a specific host defense
- Helminth infections and the immune response
- Th2 specific transcription factors
- GATA-3 promotes Th2 response via 3 mechanisms
- Importance of Th1 producing IFN-gamma cells (1)
- Importance of Th1 producing IFN-gamma cells (2)
- Susceptibility and resistance to Leishmania major
- Pulmonary tuberculosis and a Th1 cytokine profile
- IL-12 & Th1 responses in mycobacterial infections
- Th1-type responses importance: also in mice
- Critical role of TNF in controlling Mtb infection
- Th1 response differentiation pathway
- The IL-12 family
- IL-23 role in autoimmune inflammation of the brain
- Alternative IL-23 dependent T cell population
- Experimental data for the role of IL-23 in EAE
- How IL-23 may induce autoimmune inflammation
- IL-17 & IFN-gamma and pathogenesis in EAE
- IL-17 response important in pathogen eradication
- Th cell differentiation pathways
- The expanding family of innate lymphoid cells
- Th1 and Th2 differentiation and cytokines involved
- Factors underlying Th cell differentiation & function
- Regulating immune responses: IL-10, Foxp3+ Treg
- Controlling the immune responses
- Suppressor cells
- Discovery of IL-10: originally called CSIF
- B cells produce IL-10 but can stimulate Th1 cells
- IL-10: an anti-inflammatory cytokine
- Role of IL-10 in infection
- How IL-10 levels may increase in disease
- Enhanced IL-10 levels following antigen challenge
- Layers of regulation of the immune response
- IL-10 production in the gut
- Soluble antigen inhibits Th1 response via IL-10
- Tolerance induction by soluble antigen
- Neutralization of IL-10 and Th1 recall responses
- IL-10 production in the innate immune response
- Induction of colonic regulatory T cells
- IL-10 knockout versus Foxp3 knockout
- IL-10 limits the immune response
- The role of IL-10 in the immune response
- Cytokines limit immunopathology
- IL-10 and infection
- Treg cells control bacteria persistence & immunity
- CD4+ IFNgamma/IL-10 double producers
- IL-10 inhibits protective Th1 responses
- Summary: IL-10 production in the immune system
- IL-10 role in immune response: stage, specificity
Topics Covered
- Cell-cell and cytokine interactions regulating the induction and suppression of cellular immune responses
- Th1 and Th2 cells in immune regulation
- Immunosuppressive functions of IL-10
- Inhibition of antigen presentation by dendritic cells and macrophages and reduction in their production of proinflammatory cytokines
- Dendritic cells and IL-12 activation of T-cells leading to subsequent eradication of intracellular pathogens
- Roles of IL-17, IL-23 and IFN-gamma in pathogenesis and inflammation
Talk Citation
O’Garra, A. (2012, December 27). Regulation of the immune response to pathogens 1 [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 5, 2024, from https://doi.org/10.69645/QPFT4840.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Anne O’Garra has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Regulation of the immune response to pathogens 1
Published on December 27, 2012
59 min