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Printable Handouts
Navigable Slide Index
- Introduction
- Overview
- The immune response
- The innate response to infection
- Recognising infection
- Complement
- Pattern recognition receptors (PRRs)
- Natural killer cells (1)
- Natural killer cells (2)
- Proinflammatory cytokines
- The effects of the innate response
- The innate response in action
- Pattern recognition: TLR4 (1)
- Pattern recognition: TLR4 (2)
- Cell death: pyroptosis
- Cell death: apoptosis
- Septicaemia and septic shock
- Timescales (1)
- Timescales (2)
- Immune response and memory
- The adaptive response to infection
- Types of T cell
- Major histocompatibility complex
- Activation of T cells
- Activation of B cells
- Antibodies: structure and type
- Antibodies and pathogens
- Antibodies in action
- Concluding remarks
- Thank you for listening
Topics Covered
- Immune response
- Complement system
- Innate response
- Pattern recognition
- Timescales
- Adaptive response
- Activation of T and B cells
- Antibodies
Links
Series:
Categories:
Therapeutic Areas:
External Links
Talk Citation
Monie, T. (2024, October 31). Immune response to infection [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 9, 2024, from https://doi.org/10.69645/SGMC8815.Export Citation (RIS)
Publication History
Financial Disclosures
- There are no commercial/financial matters to disclose.
Transcript
Please wait while the transcript is being prepared...
0:00
Hello! Welcome to this talk on
the immune response
to infection.
My name is Prof. Tom Monie and
I'm a Professor of Pure and
Applied Biomedical Science.
I work at Christ's College as part
of the University of Cambridge.
0:17
During this talk,
I'm going to look at
how the body responds
to infections and
I'm going to focus
particularly on
those responses to
viral infection,
bacterial infection, and
parasitic infection.
We'll look at how the
innate response works and
we'll look at how the
adaptive response works,
bringing in examples from
those different types of
infections as we go through.
Thinking about what
it means in terms of
the impact and the
potential damage to
the tissues within our bodies.
0:48
The immune response can be
split into two separate parts.
The innate immune response and
the adaptive immune response.
Essentially, together
they keep us alive.
They act as a defensive barrier.
They allow us to detect threats.
Those might be from pathogens or
they might be internal threats
from parts of our own bodies.
They also enable
pathogens to be killed
so that infections
can be stopped and
that we don't become unwell.
They act as a sensor for damage.
They can tell when
parts of our body are
working correctly and
when things are going wrong,
that might need to be repaired.
One of the impacts of
the immune response is
the induction of a process
called inflammation.
This is quite a
natural response but
it's something that
often contributes to
the symptoms of a
disease or an infection.
One thing to be really
aware of is that
these two parts of
the immune system,
the innate and the adaptive,
have to work together.
If our innate immune system
isn't functioning properly,
then we won't get a
proper activation of
our adaptive system.
Broadly speaking,
when you look at