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Printable Handouts
Navigable Slide Index
- Introduction
- Asthma vs. COPD: Clinical differences
- COPD is not asthma!
- Asthma and COPD pathology
- Causes of airway obstruction in asthma and COPD
- Cellular mechanisms in asthma and COPD
- Asthma vs. COPD
- COPD vs. Asthma
- Acute exacerbations
- Trial of steroids
- Treatment choices
- Comorbidities
- Disease progression
- Dutch vs. British hypotheses
- Asthma-COPD overlap
- Similarities between asthma and COPD
- Eosinophilic COPD
- Eosinophilic inflammation in COPD
- Blood eosinophils and response to ICS
- Anti-IL-5 biologicals in COPD
- Effect of cigarette smoking on asthma
- GM-CSF in smoking asthma
- Smoking asthmatics: Airway inflammation
- Smoking and response to oral steroids
- Smoking asthma mechanisms
- Severe neutrophilic asthma
- Irreversible airflow obstruction _x000B_in asthma
- Global Initiative on Chronic Lung Disease (GOLD) and Global Initiative on Asthma (GINA)
- Conclusions
Topics Covered
- Clinical differences between Asthma and COPD
- Differences in pathology and cellular mechanisms
- Similarities in acute exacerbations
- Comorbidities and disease progression
- Differences in response to therapy
- Overlap in Asthma and COPD
- Asthma in smokers
- GOLD and GINA
Links
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Therapeutic Areas:
External Links
Talk Citation
Barnes, P. (2021, May 30). COPD and asthma: similarities and differences [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 5, 2024, from https://doi.org/10.69645/SGBK6016.Export Citation (RIS)
Publication History
Financial Disclosures
- Peter Barnes receives research grants from AstraZeneca and Boehringer-Ingelheim and is an advisor and/or gives talks for AstraZeneca, Boehringer-Ingelheim, Covis, Novartis, Pieris and Teva.
A selection of talks on Respiratory Diseases
Transcript
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0:00
Hello, I'm Peter Barnes from Imperial College in London and I'm going to talk about
the similarities and differences between asthma
and COPD, and also talk about their overlap.
0:14
There are obvious clinical differences between asthma and COPD.
If you look at the symptoms of asthma,
they are characteristically variable with intermittent wheezing,
whereas COPD patients tend to have continual symptoms, and in particular
shortness of breath (SOB) on exertion.
Asthma attends to start in childhood,
the peak age of onset for asthma is three years,
but asthma can occur for the first time at any age,
even elderly people may develop asthma for
the first time. In COPD, because the disease takes many years to develop,
patients are usually aged over 45 and usually over 60.
The courses of these diseases differ;
asthma is a variable disease with periods of remission
which may be for several years (though some patients have progressive disease),
whereas COPD patients usually have progressive air-flow limitation.
Smoking is the commonest risk factor for developing COPD in developed countries
so most COPD patients are smokers, whereas asthmatics
smoke at around the same prevalence as the normal population.
Not surprisingly, the response to treatment differs between these diseases.
Characteristically, asthma is reversible,
so there's a good response to bronchodilators,
whereas COPD has largely fixed obstruction with a poor response to bronchodilators.
Asthma patients respond well to steroids,
so steroid responsive inflammation,
whereas COPD patients usually have a poor response to
steroids because they're inflammation is largely steroid resistant.
There are similarities in both asthma and COPD are common diseases,