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- Advances in the Understanding of Etiology (I)
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1. Infection and autoimmunity: a two-way relationship
- Dr. Ricard Cervera
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2. Autoimmunity and atherosclerosis
- Prof. Johan Frostegard
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3. Endothelium and autoimmunity
- Prof. Pier Luigi Meroni
- Advances in the Understanding of Etiology (II)
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4. Prolactin has a pathogenic role in systemic lupus erythematosus
- Prof. Luis Jara-Quezada
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5. Sjögren's syndrome: current knowledge and future prospects
- Prof. Athanasios G. Tzioufas
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6. Genetic and environmental triggers of autoimmune thyroid diseases
- Prof. Yaron Tomer
- Advances in Pathogenesis and Clinical Manifestation
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8. Pathogenic mechanisms of autoantibodies: circulating and local antibodies that form immune complexes
- Dr. Luís Eduardo Coelho Andrade
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9. Pathogenic mechanisms of autoantibodies: antibodies to intracellular and membrane-bound antigens
- Dr. Luís Eduardo Coelho Andrade
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10. What causes primary biliary cholangitis?
- Dr. M. Eric Gershwin
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11. Capillaroscopy in autoimmune rheumatic diseases
- Prof. Maurizio Cutolo
- Advances in Diagnostic Methodologies (I)
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12. The past, present & future of ANA testing: history and challenges of ANA
- Prof. Marvin J. Fritzler
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13. The past, present & future of ANA testing: changing bandwidth and future of ANA
- Prof. Marvin J. Fritzler
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14. Diagnostic methods in autoimmunity
- Mr. Steven Binder
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15. Systemic lupus erythematosus: novel aspects of pathogenesis and treatment 1
- Prof. Chaim Putterman
- Dr. Noa Schwartz
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16. Systemic lupus erythematosus: novel aspects of pathogenesis and treatment 2
- Prof. Chaim Putterman
- Dr. Noa Schwartz
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17. Novel aspects of systemic sclerosis
- Prof. Gabriele Valentini
- Advances in Diagnostic Methodologies (II)
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18. An update on the multiple faces of celiac disease
- Prof. Aaron Lerner
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19. Protective autoantibodies
- Prof. Elias Toubi
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21. Rheumatic fever: a model of a post-infectious autoimmune disease
- Prof. Jorge Kalil
- Treatments of autoimmune diseases
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22. Intravenous immunoglobulins: clinical evidence
- Prof. Shaye Kivity
- Latest Developments in the Field
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23. Adjuvants and autoimmunity
- Dr. Eitan Israeli
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24. Antiphospholipid syndrome (APS): from pathogenesis to treatment
- Prof. Roger Levy
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25. Vitamin D and autoimmunity
- Dr. Shir Azrielant
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26. Pregnancy in rheumatic diseases
- Prof. Pier Luigi Meroni
- Archived Lectures *These may not cover the latest advances in the field
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27. Pathogenic mechanisms of autoantibodies
- Prof. Cees Kallenberg
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28. B lymphocytes on the frontline of autoimmunity
- Prof. Pierre Youinou
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29. Apoptotic cell clearance deficiency
- Prof. Martin Herrmann
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30. Auto-antibodies as predictors of autoimmune disease
- Dr. Nicola Bizzaro
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31. Innate immunity and natural autoantibodies
- Prof. Luc Mouthon
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32. Accelerated atherosclerosis in autoimmune rheumatic disease
- Dr. Andrea Doria
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33. Pregnancy in autoimmune rheumatic diseases
- Prof. Angela Tincani
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36. Immunologic mechanisms in systemic lupus erythematosus
- Prof. Kok-Yong Fong
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37. Osteoimmunology
- Prof. João Eurico Fonseca
- Ms. Joana Caetano-Lopes
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38. ANCA-associated systemic vasculitides
- Prof. Loic Guillevin
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39. The common origin for diverse autoimmune diseases
- Prof. Juan-Manuel Anaya
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40. Anti-cytokine therapy in rheumatoid arthritis
- Prof. Piercarlo Sarzi-Puttini
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41. Sjogren's syndrome: autoimmune epithelitis
- Prof. Haralampos Moutsopoulos
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42. Vitamin D and autoimmunity
- Dr. Howard Amital
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43. Intravenous immunoglobulins: myth and reality
- Prof. Zera Tellier
Printable Handouts
Navigable Slide Index
- Introduction
- Molecular redundancy
- Redundant molecules replace disrupted genes
- Genomic structure of the CD44 molecule
- CD44 - alternative splicing
- CD44 ligands
- Dr. Lora Eshkar Sebban
- CD44 functions
- The three steps model of Dr. Springer
- Rolling and migration of CD44-positive cells
- The migration process
- Anti-CD44 mAbs reduce pathological activities
- Anti-CD44 mAbs reduce diabetogenic activity
- Anti-CD44 mAbs reduce arthritic activity
- Generation of CIA model experimental protocol
- In-vivo efficacy in CIA model
- The CD44-dependency of CIA
- CIA is a CD44-dependent disease
- Effect of type 2 collagen injection
- CD44 DNA analysis of CD44-deficient mice
- Flow cytometry: CD44-deficient mice spleen cells
- Sensitivity to CIA: CD44-knockout vs. WT mice
- Histopathology of joints from CD44+/+ and -/- mice
- Photo imaging of histochemical staining revealed
- CD44-deficient mice: hyaluronic acid accumulation
- Anti-CD44 mAb inhibits CIA in WT DBA/1 mice
- Support of collagen-induced arthritis in mice
- Inhibition of CIA by hyaluronidase in WT mice
- Inhibition of CIA in WT and CD44-K/O mice
- CD44-deficient spleen cells bind to HA
- HA-binding protein compensates for CD44 in mice
- The HA binding protein that compensates for CD44
- RHAMM: receptor for hyaluronan-mediated motility
- RHAMM reagents
- RHAMM regulation in CD44-deficient mice (1)
- RHAMM regulation in CD44-deficient mice (2)
- Transwell migration assay
- Spleen cells migration from CD44-deficient mice
- Anti-RHAMM inhibits mice spleen cells migration
- Anti-RHAMM mAb and soluble RHAMM inhibit CIA
- CD44 affect the disease activity
- CD44 deletion affect embryonic development
- RHAMM regulation after CD44 genetic deletion
- RHAMM functions
- Interpretation of the redundancy mechanism
- Disease-specific CD44 (1)
- Disease-specific CD44 (2)
- Exploring CD44 isoforms
- Genomic sequence of: V4/V5 junction, CD44vRA
- Single amino acid exchange and proteins function
- Levels of CD44vRA Abs in mice splenocytes
- Binding F8:33 anti-CD44 mAb to synovial cells
- Synovial fluid cells from an RA and OA patient
- F8:33 anti-CD44vRA mAb bindings
- Does anti-CD44vRA Ab promote apoptosis?
- Anti-CD44vRA mAb induces apoptosis in RA (1)
- Anti-CD44vRA mAb induces apoptosis in RA (2)
- Disease-specific CD44
- Conclusions
- Acknowledgements
- Albert Einstein's wisdom...
- References
- References
Topics Covered
- CD44 and RHAMM (receptor for hyaluronan-mediated motility) are cell adhesion and cell homing receptors
- Cell migration
- Generation of different CD44 isoforms
- RHAMM also supports cell motility and is engaged in intracellular signalling
- Collagen-induced arthritis and type 1 diabetes are CD44-dependent pathologies
- Molecular redundancy
- CD44 targeting by anti-CD44 mAb may eradicate not only malignant cells and destructive inflammatory cells but also CD44-expressing normal cells which are committed to physiological functions
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Naor, D. (2017, November 28). CD44 genetic deletion enhances and CD44 antibody targeting attenuates autoimmune inflammation [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 7, 2024, from https://doi.org/10.69645/SZIG6778.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. David Naor has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
CD44 genetic deletion enhances and CD44 antibody targeting attenuates autoimmune inflammation
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