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- Advances in the Understanding of Etiology (I)
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1. Infection and autoimmunity: a two-way relationship
- Dr. Ricard Cervera
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2. Autoimmunity and atherosclerosis
- Prof. Johan Frostegard
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3. Endothelium and autoimmunity
- Prof. Pier Luigi Meroni
- Advances in the Understanding of Etiology (II)
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4. Prolactin has a pathogenic role in systemic lupus erythematosus
- Prof. Luis Jara-Quezada
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5. Sjögren's syndrome: current knowledge and future prospects
- Prof. Athanasios G. Tzioufas
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6. Genetic and environmental triggers of autoimmune thyroid diseases
- Prof. Yaron Tomer
- Advances in Pathogenesis and Clinical Manifestation
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8. Pathogenic mechanisms of autoantibodies: circulating and local antibodies that form immune complexes
- Dr. Luís Eduardo Coelho Andrade
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9. Pathogenic mechanisms of autoantibodies: antibodies to intracellular and membrane-bound antigens
- Dr. Luís Eduardo Coelho Andrade
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10. What causes primary biliary cholangitis?
- Dr. M. Eric Gershwin
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11. Capillaroscopy in autoimmune rheumatic diseases
- Prof. Maurizio Cutolo
- Advances in Diagnostic Methodologies (I)
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12. The past, present & future of ANA testing: history and challenges of ANA
- Prof. Marvin J. Fritzler
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13. The past, present & future of ANA testing: changing bandwidth and future of ANA
- Prof. Marvin J. Fritzler
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14. Diagnostic methods in autoimmunity
- Mr. Steven Binder
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15. Systemic lupus erythematosus: novel aspects of pathogenesis and treatment 1
- Prof. Chaim Putterman
- Dr. Noa Schwartz
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16. Systemic lupus erythematosus: novel aspects of pathogenesis and treatment 2
- Prof. Chaim Putterman
- Dr. Noa Schwartz
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17. Novel aspects of systemic sclerosis
- Prof. Gabriele Valentini
- Advances in Diagnostic Methodologies (II)
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18. An update on the multiple faces of celiac disease
- Prof. Aaron Lerner
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19. Protective autoantibodies
- Prof. Elias Toubi
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21. Rheumatic fever: a model of a post-infectious autoimmune disease
- Prof. Jorge Kalil
- Treatments of autoimmune diseases
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22. Intravenous immunoglobulins: clinical evidence
- Prof. Shaye Kivity
- Latest Developments in the Field
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23. Adjuvants and autoimmunity
- Dr. Eitan Israeli
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24. Antiphospholipid syndrome (APS): from pathogenesis to treatment
- Prof. Roger Levy
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25. Vitamin D and autoimmunity
- Dr. Shir Azrielant
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26. Pregnancy in rheumatic diseases
- Prof. Pier Luigi Meroni
- Archived Lectures *These may not cover the latest advances in the field
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27. Pathogenic mechanisms of autoantibodies
- Prof. Cees Kallenberg
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28. B lymphocytes on the frontline of autoimmunity
- Prof. Pierre Youinou
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29. Apoptotic cell clearance deficiency
- Prof. Martin Herrmann
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30. Auto-antibodies as predictors of autoimmune disease
- Dr. Nicola Bizzaro
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31. Innate immunity and natural autoantibodies
- Prof. Luc Mouthon
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32. Accelerated atherosclerosis in autoimmune rheumatic disease
- Dr. Andrea Doria
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33. Pregnancy in autoimmune rheumatic diseases
- Prof. Angela Tincani
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36. Immunologic mechanisms in systemic lupus erythematosus
- Prof. Kok-Yong Fong
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37. Osteoimmunology
- Prof. João Eurico Fonseca
- Ms. Joana Caetano-Lopes
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38. ANCA-associated systemic vasculitides
- Prof. Loic Guillevin
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39. The common origin for diverse autoimmune diseases
- Prof. Juan-Manuel Anaya
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40. Anti-cytokine therapy in rheumatoid arthritis
- Prof. Piercarlo Sarzi-Puttini
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41. Sjogren's syndrome: autoimmune epithelitis
- Prof. Haralampos Moutsopoulos
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42. Vitamin D and autoimmunity
- Dr. Howard Amital
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43. Intravenous immunoglobulins: myth and reality
- Prof. Zera Tellier
Printable Handouts
Navigable Slide Index
- Introduction
- Immune system overview
- Innate immunity
- Adaptive immunity
- Pathogenesis of SLE
- Major players in SLE: innate immunity
- Interferon type 1 (IFN-I)
- IFN-I in SLE
- Two independent type 1 IFN producing pathways
- IFN-I: extrinsic-induced pathway
- IFN-I: intrinsic-induced pathway
- Plasmacytoid dendritic cells (pDCs)
- Lupus-pDC characteristics
- Neutrophils
- Lupus neutrophils
- Low-density granulocytes
- NETosis (Neutrophil extracellular traps)
- NETs in lupus
- Complement system
- Complements in SLE
- Major players in SLE: adaptive immunity
- T-cells - function
- T-cells in SLE
- Adaptive autoimmunity: B cells - function
- B-cells in SLE
- Autoantibodies
Topics Covered
- Overview of innate and adaptive immunity
- Specific effectors of innate immunity in SLE
- Specific effectors of adaptive immunity in SLE
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Putterman, C. and Schwartz, N. (2019, March 31). Systemic lupus erythematosus: novel aspects of pathogenesis and treatment 1 [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 5, 2024, from https://doi.org/10.69645/RDYA4066.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Chaim Putterman, Investigator role with Exagen and research support from Boerhinger Ingelheim.
- Dr. Noa Schwartz, NIH T32AR071302-01 training grant to the Hospital for Special Surgery Research Institute Rheumatology Training Program
Systemic lupus erythematosus: novel aspects of pathogenesis and treatment 1
Published on March 31, 2019
24 min
A selection of talks on Clinical Practice
Transcript
Please wait while the transcript is being prepared...
0:00
Ladies and gentlemen, my name is Chaim Putterman.
It gives me great pleasure to introduce to you today's lecture titled
"Systemic Lupus Erythematosus," or SLE,
with a focus on "Novel Aspects of Pathogenesis and Treatment."
This is an update of a lecture that I provided several years ago to Henry Stewart Talks.
There's been a tremendous amount of progress,
both in understanding pathogenesis of lupus and in treatment modalities,
and we thought it was time to update and provide the new information.
Today's talk is being given by Noa Schwartz from the Hospital for Special Surgery,
and myself, Chaim Putterman,
from the Albert Einstein College of Medicine and Montefiore Medical Center in New York.
0:46
Systemic Lupus Erythematosus, or lupus,
is an autoimmune systemic disease that can affect many organ systems in many different ways.
While previously it was thought to be primarily antibody-driven,
it is now known that all parts of the immune system
contribute to the pathogenesis of the disease.
Therefore, before we go on to discuss
what goes wrong in the immune system of lupus patients,
we would like to briefly first present a general overview of the healthy immune system,
its main players, and some of its regulatory processes.
It is important to emphasize that we do not intend to present here
an exhaustive description of the intricacies of the immune system,
but rather to provide a basic,
yet, we hope, insightful, understanding,
of the main players that are thought to be related to the pathogenesis of lupus.
So the immune system is divided into innate immunity and adaptive immunity.
The innate immune system is considered the first line of defense against pathogens.
It is always there providing universal protection
without a need for priming to begin working effectively.
Adaptive immunity, however, is pathogen- or antigen-specific
and usually more potent but requires priming prior to activation.
Therefore, it takes more time to reach its full protective potential.
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