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1. Introduction
2. AITD
3. Etiology of AITD - infection
4. Epidemiological evidence
5. Infection and AITD
6. Molecular mimicry
7. Bystander activation
8. Etiology of AITD - iodine
9. Iodine and AITD
10. Iodine and AITD - mechanisms
11. Etiology of AITD - stress
12. Stress and Graves’ disease (GD)
13. Etiology of AITD - smoking
14. Smoking and AITD
15. Smoking and AITD - summary
16. Environmental risk factors for AITD
17. Evidence for genetic susceptibility
18. AITD cluster in families - Amsterdam cohort
19. AITD cluster in families
20. Genetic susceptibility to AITD
21. Twin studies in AITD
22. Methods for identifying complex disease genes
23. Identifying susceptibility genes for diseases
24. Gene susceptibility identification model
25. Susceptibility genes identified in AITD
26. Putative AITD susceptibility genes in Caucasians
27. The immunological synapse
28. HLA-DR in GD
29. HLA associations in GD (caucasians)
30. HLA-DR sequence variants association with GD
31. Amino acid sequences of HLA-DR3 subtypes
32. HLA-DR peptide binding groove
33. Structure of the peptide binding groove
34. Suggested mechanism
35. HLA-DR summary
36. The CTLA-4 gene in AITD (2q)
37. Function of CTLA-5
38. CTLA-4 studies in AITD (Caucasians)
39. Which variant causes autoimmunity?
40. These polymorphisms are in LD
41. Functional studies
42. Blocking CTLA-4 augments T-cell proliferation
43. Genotype association with reduced CTLA-4
44. Direct functional studies
45. Causative polymorphism mapping
46. CTLA-4 summary
47. The CD40 gene in GD
48. Function of CD40
49. A new SNP in the Kozak sequence of CD40
50. The CD40 Kozak SNP in GD
51. Kozak sequences and translation
52. Kozak SNP and CD40 translation
53. In vitro transcription/translation assay for CD40
54. CD40 surface expression on Rat2 cells
55. CD40 expression on B cells
56. FACS analysis of CD19+CD40+ purified B cells
57. Higher cell surface expression of CD40
58. Increased CD40 expression – where?
59. Transgenic mice over-expressing CD40 on TFC
60. Experimental autoimmune GD (EAGD)
61. TRAb levels in EAGD mice
62. Increase in T4 levels in EAGD mice
63. CD40 expression induce or accelerate GD
64. CD40 signaling pathways
65. Canonical pathway activation
66. Non-canonical pathway activation
67. CD40 summary
68. Development of AITD

Topics Covered

• Autoimmune thyroid diseases (AITD)
• Identification of AITD susceptibility genes
• Iodine and AITD
• MHC class II genes, CTLA-4, and CD40
• Sequencing efforts
• Environmental and genetic triggering factors of AITD
• Genetic studies and etiology of AITD
• Development of AITD

Links

Series:

• Autoimmunity

Categories:

• Genetics & Epigenetics
• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Tomer, Y. (2018, October 31). Genetic and environmental triggers of autoimmune thyroid diseases [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved February 16, 2019, from https://hstalks.com/bs/198/.

Publication History

• Published on October 1, 2007
• Updated on October 31, 2018