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1. Introduction
2. Important streptococcal species
3. S. agalactiae - neonatal sepsis and meningitis
4. S. pneumoniae
5. S. pneumoniae - a candy coated bacterium
6. S. pyogenes - the chain that links throat to heart
7. S. pyogenes infections
8. Serious life threatening complications
9. Rheumatic fever - link to the heart
10. APSGN (1)
11. APSGN (2)
12. Invasive S. pyogenes disease
13. Child-bed sepsis (puerperal sepsis)
14. Others conditions associated with S. pyogenes
15. Psoriasis and obsessive compulsive behavior
16. Microbiology of S. pyogenes
17. Identification of group A Streptococcus
18. S. pyogenes is resistant to innate immunity
19. S. pyogenes interaction with host cell
20. S. pyogenes surface is determinant of virulence
21. Masters of immune avoidance
22. Molecular mimicry - hyaluronic acid
23. Binding of HA to CD44
24. Key complement components
25. Destruction of host chemotactic signals
26. C5a peptidase (1)
27. C5a peptidase (2)
28. The M protein (1)
29. The M protein (2)
30. Tonsils are reservoir for recurrent infection
31. S. pyogenes enter tonsils through M cells
32. Streptococcal adhesins and invasins
33. Multiple pathways of invasion
34. M1-Fn and Sfb1-Fn invasion signals
35. S. pyogenes infection and TGF-beta (1)
36. S. pyogenes infection and TGF-beta (2)
37. Superantigens
38. Superantigens are nonspecific activators of T cells
39. Summary

Topics Covered

• Important Streptococcal species
• S. pyogenes: the chain that links the throat to the heart
• Life threatening complications
• Rheumatic fever
• Acute post streptococcal glomerulonephritis
• Invasive S. pyogenes disease
• Strep throat activates psoriasis and obsessive compulsive behavior
• Identification of group A streptococcus
• S. pyogenes expresses a complex array of factors that interact with host defenses
• Molecular mimicry hides bacterium from host's defenses
• Key complement components
• Destruction of host chemotactic signals is critical for initiation of infection
• C5a peptidase
• M protein
• Tonsils are reservoir for recurrent infection
• Superantigens

Links

Series:

• Molecular Basis of Bacterial Infection

Categories:

• Clinical Practice
• Microbiology

Therapeutic Areas:

• Infectious Diseases
• Oral Health

Talk Citation

Cleary, P.P. (2009, October 29). Streptococcus pyogenes disease and molecular pathogenesis [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved September 27, 2023, from https://hstalks.com/bs/1480/.
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Publication History

• Published on October 29, 2009

Financial Disclosures

• Prof. P. Patrick Cleary, Lecturer, shared royalty payments from sales of lecture series.